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Caffeine
- Family: Plantae - Rubiaceae
- Kingdom: Plantae
-
Class: Alkaloid
- Subclass: Methylxanthine Alkaloid
| Canonical Smiles | Cn1cnc2c1c(=O)n(C)c(=O)n2C |
|---|---|
| InChI | InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3 |
| InChIKey | RYYVLZVUVIJVGH-UHFFFAOYSA-N |
| Formula | C8H10N4O2 |
| HBA | 6 |
| HBD | 0 |
| MW | 194.19 |
| Rotatable Bonds | 0 |
| TPSA | 61.82 |
| LogP | -1.03 |
| Number Rings | 2 |
| Number Aromatic Rings | 2 |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Fraction CSP3 | 0.38 |
| Exact Mass | 194.08 |
| Number of Lipinski Rule Violations | 0 |
| # | Species | Family | Kingdom | NCBI Taxonomy ID |
|---|---|---|---|---|
| 1 | Bidens pilosa | Asteraceae | Plantae | 42337 |
| 2 | Coffea canephora | Rubiaceae | Plantae | 49390 |
Showing of synonyms
Caffeine
58-08-2
Guaranine
1,3,7-Trimethylxanthine
Methyltheobromine
Theine
Thein
Cafeina
Koffein
Mateina
Alert-pep
Caffein
Cafipel
Coffeine
Refresh'n
Stim
Anhydrous caffeine
Cafamil
Cafecon
Caffine
Nodaca
No-Doz
Eldiatric C
Hycomine
Organex
7-Methyltheophylline
Nix Nap
Methyltheobromide
Coffeinum
Coffein
Caffeine, synthetic
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Tirend
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethylpurine-2,6-dione
Theophylline, 7-methyl
Tri-Aqua
Kofein
Miudol
Caffeine, anhydrous
Theobromine, 1-methyl-
1-methyltheobromine
Caffeine (natural)
Xanthine, 1,3,7-trimethyl
Methylxanthine theophylline
Caffenium
Teina
Caffeina
NCI-C02733
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
CAFFEINE ANHYDROUS
FEMA No. 2224
Cafeine
Caffeinum
HSDB 36
BRN 0017705
NSC 5036
CCRIS 1314
1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione
AI3-20154
NSC-5036
EINECS 200-362-1
UNII-3G6A5W338E
Caffeine melting point standard
DTXSID0020232
CHEBI:27732
3G6A5W338E
Caffeine [USP:BAN:JAN]
DTXCID40232
ESGIC COMPONENT CAFFEINE
TRIAD COMPONENT CAFFEINE
DIMENHYDRINATE IMPURITY C
FEMCET COMPONENT CAFFEINE
TREZIX COMPONENT CAFFEINE
ANOQUAN COMPONENT CAFFEINE
NSC5036
CAFERGOT COMPONENT CAFFEINE
EC 200-362-1
EXCEDRIN COMPONENT CAFFEINE
FIORICET COMPONENT CAFFEINE
FIORINAL COMPONENT CAFFEINE
MIGERGOT COMPONENT CAFFEINE
NORGESIC COMPONENT CAFFEINE
WIGRAINE COMPONENT CAFFEINE
DHC PLUS COMPONENT CAFFEINE
INVAGESIC COMPONENT CAFFEINE
LANORINAL COMPONENT CAFFEINE
5-26-13-00558 (Beilstein Handbook Reference)
ORPHENGESIC COMPONENT CAFFEINE
SYNALGOS-DC COMPONENT CAFFEINE
1,3,7-trimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine
MEDIGESIC PLUS COMPONENT CAFFEINE
SYNALGOS-DC-A COMPONENT CAFFEINE
DARVON COMPOUND COMPONENT CAFFEINE
INVAGESIC FORTE COMPONENT CAFFEINE
CAFFEINE (IARC)
CAFFEINE [IARC]
CAFFEINE (II)
CAFFEINE [II]
ORPHENGESIC FORTE COMPONENT CAFFEINE
CAFFEINE (MART.)
CAFFEINE [MART.]
CAFFEINE (USP-RS)
CAFFEINE [USP-RS]
Caffeine (USP:BAN:JAN)
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
CAFFEINE (EP MONOGRAPH)
CAFFEINE [EP MONOGRAPH]
CAFFEINE (USP MONOGRAPH)
CAFFEINE [USP MONOGRAPH]
THEOPHYLLINE IMPURITY A (EP IMPURITY)
THEOPHYLLINE IMPURITY A [EP IMPURITY]
DIMENHYDRINATE IMPURITY C (EP IMPURITY)
DIMENHYDRINATE IMPURITY C [EP IMPURITY]
PENTOXIFYLLINE IMPURITY F (EP IMPURITY)
PENTOXIFYLLINE IMPURITY F [EP IMPURITY]
DiurexUltimate
DiurexUltra
Respia
Awake
NoSnooze
Allertness Aid
Uplift Chewable
Alertness Aid
Conrx Alert
Sprayable Energy
Stay Awake
Alert Aid
Methyltheophylline
NoSnoozeCircle K
Careone stay awake
Caffeine 200mg
Diurex Water Pills
Topcare Stay Awake
Caffeine1508
NoDoz Alertness Aid
AwakeMaximum Strength
Sohmed Alertness Aid
357 Super Magnum
Diurex Water PillsXPL
Alertness Aid Stay Awake
Caffeine 200 mg Tablets
Jet Alert Double Strength
Stay AwakeMaximum Strength
Jet Alert Regular Strength
Caffeine Tablets, 200 mg
Caffeine tablet, film-coated
CAFFEINE COMPONENT OF ESGIC
CAFFEINE COMPONENT OF TRIAD
Topcare Stay AwakeMaximum Strength
CAFFEINE COMPONENT OF FEMCET
NoDoz Alertness AidMaximum Strength
CAFFEINE COMPONENT OF ANOQUAN
Carolina Cannabis Uplifting Chewables
Valumeds Maximum Strength Stay Awake
CAFFEINE COMPONENT OF CAFERGOT
CAFFEINE COMPONENT OF DHC PLUS
CAFFEINE COMPONENT OF EXCEDRIN
CAFFEINE COMPONENT OF FIORICET
CAFFEINE COMPONENT OF FIORINAL
CAFFEINE COMPONENT OF MIGERGOT
CAFFEINE COMPONENT OF NORGESIC
CAFFEINE COMPONENT OF WIGRAINE
CAFFEINE COMPONENT OF INVAGESIC
CAFFEINE COMPONENT OF LANORINAL
CAFFEINE COMPONENT OF ORPHENGESIC
USEPA/OPP Pesticide Code: 000660
CAFFEINE COMPONENT OF SYNALGOS-DC
CAFFEINE COMPONENT OF SYNALGOS-DC-A
CAFFEINE COMPONENT OF MEDIGESIC PLUS
CAFFEINE COMPONENT OF DARVON COMPOUND
CAFFEINE COMPONENT OF INVAGESIC FORTE
CAFFEINE COMPONENT OF ORPHENGESIC FORTE
200-362-1
Alert
Caffedrine
Vivarin
Dexitac
Durvitan
Phensal
Quick-Pep
Synalgos
DHCplus
1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
Propoxyphene Compound 65
Kofein [Czech]
Coffein [German]
Koffein [German]
Caffeina [Italian]
Theophylline Me
Theobromine Me
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
SK-65 Compound
Lanorinal
Anacin
Anacin Maximum Strength
P-A-C Analgesic Tablets
A.S.A. and Codeine Compound
MFCD00005758
CHEMBL113
CFF
Caffeine-13C
Caffeine-13C3
SK 65 Compound
Caffeine [BAN:JAN]
Propoxyphene Compound-65
CAS-58-08-2
Caffeine (USP)
SMR000326667
Darvon compound-65
SR-01000075187
Anhydrous caffeine (TN)
Monomethyl derivative of Theophylline
Anhydrous caffeine (JP15)
Metilteobromina
Kafeina
Trimetilksantina
1gfz
Caffeine, BioXtra
TNP00310
Monohydrate Caffeine
Respia (TN)
1-methyl-Theobromine
7-methyl Theophylline
Cafergot (Salt/Mix)
1,7-Trimethylxanthine
Spectrum_001301
1l5q
1l7x
2a3b
3g6m
3,7-dihydro-1,3,7-trimethyl-1H-purine
CAFFEINE [FHFI]
CAFFEINE [HSDB]
CAFFEINE [FCC]
Xanthine,3,7-trimethyl
CAFFEINE [MI]
1 3 7-trimetilksantina
CAFFEINE [VANDF]
CAFFEINUM [HPUS]
1,3,7-Trimethylxantine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Lopac-C-0750
1 3 7-Trimethylxanthine
Bmse000206
CAFFEINE [WHO-DD]
CAFFEINE [WHO-IP]
MolMap_000054
Probes1_000150
Probes2_000128
C 0750
SCHEMBL5671
Anhydrous caffeine (JP18)
NCIOpen2_008255
BIDD:PXR0172
Lopac0_000228
BSPBio_001921
GTPL407
KBioGR_002325
KBioSS_001781
1,3,7-trimethyl-1,3,7-trihydropurine-2,6-dione
MLS001055341
MLS001056714
MLS001066409
BIDD:ER0554
BIDD:GT0632
Caffeine, 1mg/ml in methanol
DivK1c_000730
SPECTRUM1500155
CU-01000012617-3
SPBio_001222
CAFFEINE [ORANGE BOOK]
829 - Tea quality parameters
MEGxp0_001350
ANHYDROUS CAFFEINE [JAN]
Component of Dilone (Salt/Mix)
1,7-Trimethyl-2,6-dioxopurine
ACon1_000085
BDBM10849
HMS502E12
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
Caffeine 1.0 mg/ml in Methanol
CAFFEINE(3-METHYL-13C)
COFFEINUM [WHO-IP LATIN]
Caffeine, powder, ReagentPlus(R)
Component of Percodan (Salt/Mix)
NINDS_000730
Bio1_000473
Bio1_000962
Bio1_001451
HMS1920I09
HMS2091O11
HMS2232M13
HMS3260N17
HMS3372J18
HMS3435F10
HMS3715D13
Pharmakon1600-01500155
NoDoz Caplets and Chewable Tablets
Caffeine 10 microg/mL in Methanol
CAFFEINE ANHYDROUS [WHO-IP]
CIA28298
CS-M0795
DDA07266
XCA23885
Tox21_201685
Tox21_300010
Tox21_500228
Caffeine (1,3,7-trimethylxanthine)
Caffeine 100 microg/mL in Methanol
CCG-38825
HB2846
NSC755917
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
STK177283
Propoxyphene Compound 65 (Salt/Mix)
AKOS000121334
5-26-13-00558 (Beilstein)
Bayer Select Headache Pain (Salt/Mix)
Caffeine, anhydrous, 99%, FCC, FG
DB00201
FT05891
LP00228
NSC-755917
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SDCCGSBI-0050216.P005
IDI1_000730
3,3,7-trimethyl-1H-purine-2,6-dione
NCGC00015208-01
NCGC00015208-02
NCGC00015208-03
NCGC00015208-04
NCGC00015208-05
NCGC00015208-06
NCGC00015208-07
NCGC00015208-08
NCGC00015208-10
NCGC00015208-11
NCGC00015208-12
NCGC00015208-13
NCGC00015208-14
NCGC00015208-15
NCGC00015208-16
NCGC00015208-17
NCGC00015208-18
NCGC00015208-20
NCGC00015208-27
NCGC00015208-29
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCGC00254057-01
NCGC00259234-01
NCGC00260913-01
95789-13-2
AC-12774
AS-15340
Caffeine, SAJ special grade, >=98.5%
Component of P-A-C Compound (Salt/Mix)
Component of A.S.A. Compound (Salt/Mix)
SBI-0050216.P004
DB-023002
WLN: T56 BN DN FNVNVJ B1 F1 H1
C2042
EU-0100228
NS00000273
526 - Nutritional Analysis of Energy Drinks
EN300-21663
BIM-0050216.0001
C07481
D00528
Q60235
1,3,7-trimethyl-3,7-dihydropurine-2,6-dione
1H-Purine-2, 3,7-dihydro-1,3,7-trimethyl-
AB00051930-09
AB00051930_10
Caffeine, purum, anhydrous, >=99.0% (HPLC)
3,7-dihydro-1,3,7-trimethyl-1H-purine (9CI)
Caffeine, anhydrous, tested according to Ph.Eur.
L000155
Caffeine, Sigma Reference Standard, vial of 250 mg
SR-01000075187-1
SR-01000075187-4
SR-01000075187-7
SR-01000075187-8
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRD-K02404261-001-07-6
BRD-K02404261-001-16-7
Caffeine, certified reference material, TraceCERT(R)
Caffeine, meets USP testing specifications, anhydrous
Melting point standard 235-237C, analytical standard
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione #
Caffeine, British Pharmacopoeia (BP) Reference Standard
Caffeine, European Pharmacopoeia (EP) Reference Standard
F3371-0262
THEOPHYLLINE MONOHYDRATE IMPURITY A [EP IMPURITY]
Z104507896
07E4FB58-FD79-4175-8E3D-05BF96954522
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion (coffein)
Caffeine, United States Pharmacopeia (USP) Reference Standard
Caffeine, Pharmaceutical Secondary Standard
Certified Reference Material
Caffeine for system suitability, European Pharmacopoeia (EP) Reference Standard
Caffeine melting point standard, United States Pharmacopeia (USP) Reference Standard
InChI=1/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H
114303-55-8
Caffeine Melting Point Standard, Pharmaceutical Secondary Standard
Mettler-Toledo Calibration substance ME 18872, Caffeine, analytical standard, for the calibration of the thermosystem 900, traceable to primary standards (LGC)
- Sarker SD, Bartholomew B, et al. (2000). 5-O-methylhoslundin: An unusual flavonoid from Bidens pilosa (Asteraceae). Biochemical Systematics and Ecology,2000,28(6),591-593. [View] [PubMed]
- Mewaba S, Happi E, et al. (2022). Antibacterial compounds of the cultivated Robusta coffee: Coffea canephora Pierre ex A. Froehner. Scientific African, 2022, 16, e01274. [View]
Pubchem:
2519
Cas:
58-08-2
Gnps:
CCMSLIB00005884025
Zinc:
ZINC000000001084
Kegg Ligand:
C07481
Chebi:
27732
Nmrshiftdb2:
10016316
Metabolights:
MTBLC27732
Chembl:
CHEMBL113
Comptox:
DTXSID0020232
Drugbank:
DB00201
Pdb Ligand:
CFF
Bindingdb:
10849
CPRiL:
1234
SMILES: [nH]1cnc(c12)[nH]c(=O)[nH]c2=O
Level: 0
Mol. Weight: 194.19 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -4.9
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.25
- Human Oral Bioavailability 50%
- Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -3.15
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 0.1
- Plasma Protein Binding
- 28.78
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Non-Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 7.63
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- -0.05
- Biodegradation
- Toxic
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- 1.39
- Liver Injury II
- Toxic
- hERG Blockers
- Safe
- Daphnia Maga
- 6.68
- Micronucleos
- Toxic
- NR-AhR
- Safe
- NR-AR
- Safe
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Safe
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- 2.27
- Rat (Acute)
- 2.78
- Rat (Chronic Oral)
- 1.45
- Fathead Minnow
- 4.01
- Respiratory Disease
- Toxic
- Skin Sensitisation
- Toxic
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 377.28
- Hydration Free Energy
- -12.94
- Log(D) at pH=7.4
- -0.09
- Log(P)
- -0.11
- Log S
- -0.86
- Log(Vapor Pressure)
- -5.22
- Melting Point
- 185.84
- pKa Acid
- 4.46
- pKa Basic
- 3.98
| Protein Name | UniProt ID | Entry Name | Species | #Pharmacophore Points | Probability (0.7 ≤ Tversky Score ≤ 1.0) |
|---|---|---|---|---|---|
| Toxoflavin degrading enzyme | E3SET7 | E3SET7_PAEPO | Paenibacillus polymyxa | 3 | 0.9641 |
| Toxoflavin degrading enzyme | E3SET7 | E3SET7_PAEPO | Paenibacillus polymyxa | 3 | 0.9641 |
| Albumin | P02768 | ALBU_HUMAN | Homo sapiens | 3 | 0.9563 |
| Albumin | P02768 | ALBU_HUMAN | Homo sapiens | 3 | 0.9563 |
| Acetylcholinesterase | P22303 | ACES_HUMAN | Homo sapiens | 3 | 0.9503 |
| Acetylcholinesterase | P22303 | ACES_HUMAN | Homo sapiens | 3 | 0.9503 |
| Probable esterase KAI2 | Q9SZU7 | KAI2_ARATH | Arabidopsis thaliana | 3 | 0.9294 |
| Probable esterase KAI2 | Q9SZU7 | KAI2_ARATH | Arabidopsis thaliana | 3 | 0.9294 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Q08499 | PDE4D_HUMAN | Homo sapiens | 3 | 0.9214 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Q08499 | PDE4D_HUMAN | Homo sapiens | 3 | 0.9214 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9177 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9177 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.9077 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.9077 |
| Odorant-binding protein | P81245 | OBP_PIG | Sus scrofa | 3 | 0.9076 |
| Odorant-binding protein | P81245 | OBP_PIG | Sus scrofa | 3 | 0.9076 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9043 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.9043 |
| 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | Q84HC8 | NCSB1_STRCZ | Streptomyces carzinostaticus | 3 | 0.8999 |
| 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | Q84HC8 | NCSB1_STRCZ | Streptomyces carzinostaticus | 3 | 0.8999 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.8970 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.8970 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.8939 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 3 | 0.8939 |
| Cyclin-dependent kinase 2 | P24941 | CDK2_HUMAN | Homo sapiens | 3 | 0.8930 |
| Cyclin-dependent kinase 2 | P24941 | CDK2_HUMAN | Homo sapiens | 3 | 0.8930 |
| Mycinamicin III 3''-O-methyltransferase | Q49492 | MYCF_MICGR | Micromonospora griseorubida | 2 | 0.8913 |
| Mycinamicin III 3''-O-methyltransferase | Q49492 | MYCF_MICGR | Micromonospora griseorubida | 2 | 0.8913 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | P48736 | PK3CG_HUMAN | Homo sapiens | 4 | 0.8886 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | P48736 | PK3CG_HUMAN | Homo sapiens | 4 | 0.8886 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Q08499 | PDE4D_HUMAN | Homo sapiens | 3 | 0.8875 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Q08499 | PDE4D_HUMAN | Homo sapiens | 3 | 0.8875 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.8860 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.8860 |
| 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | Q84HC8 | NCSB1_STRCZ | Streptomyces carzinostaticus | 3 | 0.8859 |
| 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase | Q84HC8 | NCSB1_STRCZ | Streptomyces carzinostaticus | 3 | 0.8859 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 3 | 0.8811 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 3 | 0.8811 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 4 | 0.8799 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 4 | 0.8799 |
| Succinate dehydrogenase flavoprotein subunit | P0AC41 | SDHA_ECOLI | Escherichia coli | 3 | 0.8798 |
| Succinate dehydrogenase flavoprotein subunit | P0AC41 | SDHA_ECOLI | Escherichia coli | 3 | 0.8798 |
| Biflaviolin synthase CYP158A2 | Q9FCA6 | C1582_STRCO | Streptomyces coelicolor / M145) | 3 | 0.8775 |
| Biflaviolin synthase CYP158A2 | Q9FCA6 | C1582_STRCO | Streptomyces coelicolor / M145) | 3 | 0.8775 |
| Biflaviolin synthase CYP158A2 | Q9FCA6 | C1582_STRCO | Streptomyces coelicolor / M145) | 3 | 0.8767 |
| Biflaviolin synthase CYP158A2 | Q9FCA6 | C1582_STRCO | Streptomyces coelicolor / M145) | 3 | 0.8767 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.8731 |
| ADP-ribosylation factor 1 | P84080 | ARF1_BOVIN | Bos taurus | 3 | 0.8731 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.8713 |
| Casein kinase II subunit alpha | P28523 | CSK2A_MAIZE | Zea mays | 3 | 0.8713 |
| Carminomycin 4-O-methyltransferase DnrK | Q06528 | DNRK_STRPE | Streptomyces peucetius | 3 | 0.8692 |
| Carminomycin 4-O-methyltransferase DnrK | Q06528 | DNRK_STRPE | Streptomyces peucetius | 3 | 0.8692 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 3 | 0.8671 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 3 | 0.8671 |
| Ribosomal small subunit pseudouridine synthase A | P0AA43 | RSUA_ECOLI | Escherichia coli | 3 | 0.8650 |
| Ribosomal small subunit pseudouridine synthase A | P0AA43 | RSUA_ECOLI | Escherichia coli | 3 | 0.8650 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.8636 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.8636 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.8578 |
| Sulfotransferase 2B1 | O00204 | ST2B1_HUMAN | Homo sapiens | 2 | 0.8578 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Q9Y233 | PDE10_HUMAN | Homo sapiens | 3 | 0.8564 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Q9Y233 | PDE10_HUMAN | Homo sapiens | 3 | 0.8564 |
| Caspase-7 | P55210 | CASP7_HUMAN | Homo sapiens | 3 | 0.8485 |
| Caspase-7 | P55210 | CASP7_HUMAN | Homo sapiens | 3 | 0.8485 |
| Biflaviolin synthase CYP158A1 | Q9KZF5 | C1581_STRCO | Streptomyces coelicolor / M145) | 3 | 0.8483 |
| Biflaviolin synthase CYP158A1 | Q9KZF5 | C1581_STRCO | Streptomyces coelicolor / M145) | 3 | 0.8483 |
| Aromatase | P11511 | CP19A_HUMAN | Homo sapiens | 3 | 0.8414 |
| Aromatase | P11511 | CP19A_HUMAN | Homo sapiens | 3 | 0.8414 |
| Acetylcholine-binding protein | P58154 | ACHP_LYMST | Lymnaea stagnalis | 3 | 0.8323 |
| Acetylcholine-binding protein | P58154 | ACHP_LYMST | Lymnaea stagnalis | 3 | 0.8323 |
| Eugenol synthase 1 | Q15GI4 | EGS1_OCIBA | Ocimum basilicum | 3 | 0.8254 |
| Eugenol synthase 1 | Q15GI4 | EGS1_OCIBA | Ocimum basilicum | 3 | 0.8254 |
| AGAP003309-PA | A0A1U7F4W2 | A0A1U7F4W2_ANOGA | Anopheles gambiae | 3 | 0.8189 |
| AGAP003309-PA | A0A1U7F4W2 | A0A1U7F4W2_ANOGA | Anopheles gambiae | 3 | 0.8189 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.8144 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.8144 |
| Serine/threonine-protein kinase Chk1 | O14757 | CHK1_HUMAN | Homo sapiens | 3 | 0.8081 |
| Serine/threonine-protein kinase Chk1 | O14757 | CHK1_HUMAN | Homo sapiens | 3 | 0.8081 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 2 | 0.8043 |
| Lactoylglutathione lyase | Q9CPU0 | LGUL_MOUSE | Mus musculus | 2 | 0.8043 |
| Deoxynucleoside kinase | Q9XZT6 | DNK_DROME | Drosophila melanogaster | 5 | 0.8040 |
| Deoxynucleoside kinase | Q9XZT6 | DNK_DROME | Drosophila melanogaster | 5 | 0.8040 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.8019 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.8019 |
| Albumin | P02769 | ALBU_BOVIN | Bos taurus | 3 | 0.7912 |
| Albumin | P02769 | ALBU_BOVIN | Bos taurus | 3 | 0.7912 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 3 | 0.7893 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 3 | 0.7893 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7813 |
| Sex hormone-binding globulin | P04278 | SHBG_HUMAN | Homo sapiens | 3 | 0.7813 |
| 3-ketosteroid dehydrogenase | Q9RA02 | Q9RA02_RHOER | Rhodococcus erythropolis | 2 | 0.7792 |
| 3-ketosteroid dehydrogenase | Q9RA02 | Q9RA02_RHOER | Rhodococcus erythropolis | 2 | 0.7792 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 3 | 0.7782 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 3 | 0.7782 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7764 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7764 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | P62942 | FKB1A_HUMAN | Homo sapiens | 3 | 0.7721 |
| Peptidyl-prolyl cis-trans isomerase FKBP1A | P62942 | FKB1A_HUMAN | Homo sapiens | 3 | 0.7721 |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | O76083 | PDE9A_HUMAN | Homo sapiens | 3 | 0.7704 |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | O76083 | PDE9A_HUMAN | Homo sapiens | 3 | 0.7704 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 2 | 0.7697 |
| Retinoic acid receptor RXR-alpha | P19793 | RXRA_HUMAN | Homo sapiens | 2 | 0.7697 |
| Carbonic anhydrase 2 | P00918 | CAH2_HUMAN | Homo sapiens | 3 | 0.7676 |
| Carbonic anhydrase 2 | P00918 | CAH2_HUMAN | Homo sapiens | 3 | 0.7676 |
| Achbp | I6L8L2 | I6L8L2_CAPTE | Capitella teleta | 3 | 0.7671 |
| Achbp | I6L8L2 | I6L8L2_CAPTE | Capitella teleta | 3 | 0.7671 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7619 |
| Aldo-keto reductase family 1 member C2 | P52895 | AK1C2_HUMAN | Homo sapiens | 2 | 0.7619 |
| Glutamate receptor 3 | P19492 | GRIA3_RAT | Rattus norvegicus | 3 | 0.7614 |
| Glutamate receptor 3 | P19492 | GRIA3_RAT | Rattus norvegicus | 3 | 0.7614 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7581 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7581 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7580 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7580 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Q08499 | PDE4D_HUMAN | Homo sapiens | 3 | 0.7568 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | Q08499 | PDE4D_HUMAN | Homo sapiens | 3 | 0.7568 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7562 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7562 |
| Chitinase A | Q9AMP1 | Q9AMP1_VIBHA | Vibrio harveyi | 2 | 0.7558 |
| Chitinase A | Q9AMP1 | Q9AMP1_VIBHA | Vibrio harveyi | 2 | 0.7558 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7511 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7511 |
| Pancreatic alpha-amylase | P04746 | AMYP_HUMAN | Homo sapiens | 2 | 0.7445 |
| Pancreatic alpha-amylase | P04746 | AMYP_HUMAN | Homo sapiens | 2 | 0.7445 |
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Q8N5Z0 | AADAT_HUMAN | Homo sapiens | 2 | 0.7438 |
| Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Q8N5Z0 | AADAT_HUMAN | Homo sapiens | 2 | 0.7438 |
| 3-phosphoinositide-dependent protein kinase 1 | O15530 | PDPK1_HUMAN | Homo sapiens | 3 | 0.7426 |
| 3-phosphoinositide-dependent protein kinase 1 | O15530 | PDPK1_HUMAN | Homo sapiens | 3 | 0.7426 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7421 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7421 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | O00408 | PDE2A_HUMAN | Homo sapiens | 2 | 0.7412 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | O00408 | PDE2A_HUMAN | Homo sapiens | 2 | 0.7412 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 2 | 0.7406 |
| NPC intracellular cholesterol transporter 1 | O15118 | NPC1_HUMAN | Homo sapiens | 2 | 0.7406 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7400 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7400 |
| Carbonic anhydrase 2 | P00918 | CAH2_HUMAN | Homo sapiens | 2 | 0.7400 |
| Carbonic anhydrase 2 | P00918 | CAH2_HUMAN | Homo sapiens | 2 | 0.7400 |
| Alcohol dehydrogenase E chain | P00327 | ADH1E_HORSE | Equus caballus | 3 | 0.7385 |
| Alcohol dehydrogenase E chain | P00327 | ADH1E_HORSE | Equus caballus | 3 | 0.7385 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7350 |
| Steroid Delta-isomerase | P07445 | SDIS_PSEPU | Pseudomonas putida | 2 | 0.7350 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7346 |
| Acetylcholinesterase | P04058 | ACES_TETCF | Tetronarce californica | 3 | 0.7346 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7337 |
| Aldo-keto reductase family 1 member D1 | P51857 | AK1D1_HUMAN | Homo sapiens | 2 | 0.7337 |
| Metallo-beta-lactamase type 2 | C7C422 | BLAN1_KLEPN | Klebsiella pneumoniae | 2 | 0.7319 |
| Metallo-beta-lactamase type 2 | C7C422 | BLAN1_KLEPN | Klebsiella pneumoniae | 2 | 0.7319 |
| Nuclear receptor ROR-beta | P45446 | RORB_RAT | Rattus norvegicus | 2 | 0.7302 |
| Nuclear receptor ROR-beta | P45446 | RORB_RAT | Rattus norvegicus | 2 | 0.7302 |
| Gastrotropin | Q6IMW5 | Q6IMW5_DANRE | Danio rerio | 2 | 0.7295 |
| Gastrotropin | Q6IMW5 | Q6IMW5_DANRE | Danio rerio | 2 | 0.7295 |
| Capsid protein | Q9WBP8 | Q9WBP8_9VIRU | Adeno-associated virus - 1 | 2 | 0.7288 |
| Capsid protein | Q9WBP8 | Q9WBP8_9VIRU | Adeno-associated virus - 1 | 2 | 0.7288 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | P14061 | DHB1_HUMAN | Homo sapiens | 2 | 0.7284 |
| 17-beta-hydroxysteroid dehydrogenase type 1 | P14061 | DHB1_HUMAN | Homo sapiens | 2 | 0.7284 |
| Beta-secretase 1 | P56817 | BACE1_HUMAN | Homo sapiens | 2 | 0.7280 |
| Beta-secretase 1 | P56817 | BACE1_HUMAN | Homo sapiens | 2 | 0.7280 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 2 | 0.7275 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 2 | 0.7275 |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | O76083 | PDE9A_HUMAN | Homo sapiens | 2 | 0.7274 |
| High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | O76083 | PDE9A_HUMAN | Homo sapiens | 2 | 0.7274 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7257 |
| Cytochrome P450 monooxygenase | Q5YNS8 | Q5YNS8_NOCFA | Nocardia farcinica | 2 | 0.7257 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7250 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7250 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 2 | 0.7235 |
| Aldo-keto reductase family 1 member B1 | P15121 | ALDR_HUMAN | Homo sapiens | 2 | 0.7235 |
| cAMP-dependent protein kinase catalytic subunit alpha | P17612 | KAPCA_HUMAN | Homo sapiens | 2 | 0.7226 |
| cAMP-dependent protein kinase catalytic subunit alpha | P17612 | KAPCA_HUMAN | Homo sapiens | 2 | 0.7226 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 2 | 0.7221 |
| Mineralocorticoid receptor | P08235 | MCR_HUMAN | Homo sapiens | 2 | 0.7221 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7218 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7218 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7199 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7199 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7187 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7187 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 2 | 0.7176 |
| Steroid Delta-isomerase | P00947 | SDIS_COMTE | Comamonas testosteroni | 2 | 0.7176 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 3 | 0.7173 |
| Photosynthetic reaction center cytochrome c subunit | P07173 | CYCR_BLAVI | Blastochloris viridis | 3 | 0.7173 |
| Heat shock protein HSP 90-alpha | P07900 | HS90A_HUMAN | Homo sapiens | 3 | 0.7152 |
| Heat shock protein HSP 90-alpha | P07900 | HS90A_HUMAN | Homo sapiens | 3 | 0.7152 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7149 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7149 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7144 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7144 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7126 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7126 |
| Aldo-keto reductase family 1 member B1 | P80276 | ALDR_PIG | Sus scrofa | 4 | 0.7106 |
| Aldo-keto reductase family 1 member B1 | P80276 | ALDR_PIG | Sus scrofa | 4 | 0.7106 |
| Heat shock protein HSP 90-alpha | P07900 | HS90A_HUMAN | Homo sapiens | 3 | 0.7101 |
| Heat shock protein HSP 90-alpha | P07900 | HS90A_HUMAN | Homo sapiens | 3 | 0.7101 |
| Uridine phosphorylase | P0A1F6 | UDP_SALTY | Salmonella typhimurium | 3 | 0.7099 |
| Uridine phosphorylase | P0A1F6 | UDP_SALTY | Salmonella typhimurium | 3 | 0.7099 |
| Serine/threonine-protein kinase Chk2 | O96017 | CHK2_HUMAN | Homo sapiens | 2 | 0.7093 |
| Serine/threonine-protein kinase Chk2 | O96017 | CHK2_HUMAN | Homo sapiens | 2 | 0.7093 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7077 |
| Gag-Pol polyprotein | P04585 | POL_HV1H2 | Human immunodeficiency virus type 1 group M subtype B | 3 | 0.7077 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q04631 | FNTA_RAT | Rattus norvegicus | 3 | 0.7064 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Q04631 | FNTA_RAT | Rattus norvegicus | 3 | 0.7064 |
| Mycinamicin III 3''-O-methyltransferase | Q49492 | MYCF_MICGR | Micromonospora griseorubida | 2 | 0.7054 |
| Mycinamicin III 3''-O-methyltransferase | Q49492 | MYCF_MICGR | Micromonospora griseorubida | 2 | 0.7054 |
| Thymidine kinase | P0DTH5 | KITH_HHV11 | Human herpesvirus 1 | 2 | 0.7034 |
| Thymidine kinase | P0DTH5 | KITH_HHV11 | Human herpesvirus 1 | 2 | 0.7034 |
| Major pollen allergen Bet v 1-A | P15494 | BEV1A_BETPN | Betula pendula | 2 | 0.7024 |
| Major pollen allergen Bet v 1-A | P15494 | BEV1A_BETPN | Betula pendula | 2 | 0.7024 |
| Polymerase acidic protein | C3W5S0 | C3W5S0_I09A0 | Influenza A virus | 2 | 0.7022 |
| Polymerase acidic protein | C3W5S0 | C3W5S0_I09A0 | Influenza A virus | 2 | 0.7022 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | P27815 | PDE4A_HUMAN | Homo sapiens | 3 | 0.7005 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | P27815 | PDE4A_HUMAN | Homo sapiens | 3 | 0.7005 |