Neonthrene - Compound Card

Neonthrene

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Neonthrene

Structure
Zoomed Structure
  • Family: Euphorbiaceae
  • Kingdom: Plantae
  • Class: Phenantherene
    • Subclass: Dihydrophenantherene
Canonical Smiles COc1c(O)cc2c(c1C)CCc1c2cc(O)c(c1)C
InChI InChI=1S/C17H18O3/c1-9-6-11-4-5-12-10(2)17(20-3)16(19)8-14(12)13(11)7-15(9)18/h6-8,18-19H,4-5H2,1-3H3
InChIKey PJYLCZOMUJYTKK-UHFFFAOYSA-N
Formula C17H18O3
HBA 3
HBD 2
MW 270.33
Rotatable Bonds 1
TPSA 49.69
LogP 3.49
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 270.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Neoboutonia macrocalyx Euphorbiaceae Plantae 1260343

Showing of synonyms

  • Namukobe J, Kiremire BT, et al. (2014). Cycloartane triterpenes from the leaves of Neoboutonia macrocalyx L.. Phytochemistry,2014,102,189-196. [View] [PubMed]
Pubchem: 163052115

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)CCc2cccc3

Level: 0

Mol. Weight: 180.25 g/mol

Anti-plasmodial
Cytotoxic

Absorption

Caco-2 (logPapp)
-4.89
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.550
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.24

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.060
Plasma Protein Binding
65.47
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.800
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.650
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.640
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.040
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.910
Rat (Acute)
1.860
Rat (Chronic Oral)
2.410
Fathead Minnow
4.520
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
381.830
Hydration Free Energy
-7.750
Log(D) at pH=7.4
3.860
Log(P)
3.63
Log S
-4.44
Log(Vapor Pressure)
-6.32
Melting Point
210.07
pKa Acid
10.22
pKa Basic
6.48
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9488
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9488
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.9460
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.9460
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9442
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9442
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9335
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9335
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9327
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9327
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9299
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.9299
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9151
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9151
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9103
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9103
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9086
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9086
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8951
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8951
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8948
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8948
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.8902
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.8902
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8886
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8886
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8719
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8719
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8637
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8637
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8576
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8576
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8539
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8539
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8457
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8457
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8453
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8453
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8425
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8425
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8389
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8389
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8354
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8354
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8201
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8201
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8171
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8171
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8163
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8163
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8155
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8155
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8105
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8105
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8087
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8087
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8081
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8081
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.8072
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.8072
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8064
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8064
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8037
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8037
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7997
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7997
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7957
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7957
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7951
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7951
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7939
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7939
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7937
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7937
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7929
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7929
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7923
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7923
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7919
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7919
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7913
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7913
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7901
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7901
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7887
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7887
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7874
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7874
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7843
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7843
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7827
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7827
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7822
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7822
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7806
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7806
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7795
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7795
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7793
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7793
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7753
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.7753
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7743
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7743
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7728
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7728
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7726
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7726
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7685
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7685
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7665
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7665
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7635
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7635
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7620
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7620
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7619
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7619
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7617
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7617
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7583
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7583
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7567
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7567
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7544
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7544
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7534
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7534
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7531
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7531
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7517
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7517
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7510
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7510
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7508
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7508
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7484
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7484
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7482
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7482
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7481
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7481
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7478
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7478
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7463
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7463
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7454
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7454
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7453
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7453
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 4 0.7441
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 4 0.7441
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7437
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7437
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.7386
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 4 0.7386
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7382
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7382
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7380
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7380
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7379
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7379
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7368
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7368
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7361
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7361
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7350
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7350
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7338
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7338
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7324
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7324
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7300
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7300
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7294
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7294
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7291
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7291
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7287
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7287
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7286
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7286
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7280
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7280
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7279
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7279
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7264
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7264
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7260
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7260
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 3 0.7260
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7260
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7245
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7245
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7228
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7228
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7225
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7225
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7221
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7221
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7208
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7208
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7204
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7204
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7204
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7204
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7200
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7200
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 4 0.7200
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 4 0.7200
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7198
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7198
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7197
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7197
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7179
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7179
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7162
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7162
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7158
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7158
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7154
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7154
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7153
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7153
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7152
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7152
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7135
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7135
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7128
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7128
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7110
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7110
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7109
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7109
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7106
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7106
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7088
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7088
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7077
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7077
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7068
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7068
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7067
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7067
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7066
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7066
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7053
11-beta-hydroxysteroid dehydrogenase 1 Q6QLL4 DHI1_CAVPO Cavia porcellus 3 0.7053
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7048
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7048
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7046
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7046
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7040
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7040
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7022
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7022
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7004
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7004

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