Crotonimide C - Compound Card

Crotonimide C

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Crotonimide C

Structure
Zoomed Structure
  • Family: Euphorbiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Glutarimide Alkaloid
Canonical Smiles O=C(c1ccccc1)N[C@H]1CCC(=O)N(C1=O)CCc1ccccc1
InChI InChI=1S/C20H20N2O3/c23-18-12-11-17(21-19(24)16-9-5-2-6-10-16)20(25)22(18)14-13-15-7-3-1-4-8-15/h1-10,17H,11-14H2,(H,21,24)/t17-/m0/s1
InChIKey BBMKJZGHTCVFMA-KRWDZBQOSA-N
Formula C20H20N2O3
HBA 3
HBD 1
MW 336.39
Rotatable Bonds 5
TPSA 66.48
LogP 2.18
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 336.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Croton alienus Euphorbiaceae Plantae 100370

Showing of synonyms

  • Ndunda B, Langat MK, et al. (2013). Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.. Planta Med,2013,79(18),1762-1766. [View] [PubMed]
Pubchem: 73425694

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)NC(C2=O)CCC(=O)N2CCc3ccccc3

Level: 2

Mol. Weight: 336.39 g/mol

Structure

SMILES: N1C(=O)CCC(C1=O)NC(=O)c2ccccc2

Level: 1

Mol. Weight: 232.24 g/mol

Structure

SMILES: c1ccccc1CCN2C(=O)CCCC2=O

Level: 1

Mol. Weight: 217.27 g/mol

Structure

SMILES: O=C1CCCC(=O)N1

Level: 0

Mol. Weight: 113.12 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.93
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.4
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.4

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.93
Plasma Protein Binding
79.01
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.58
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.01
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.23
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
7.07
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-2.13
Rat (Acute)
2.35
Rat (Chronic Oral)
1.82
Fathead Minnow
4.13
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
410.48
Hydration Free Energy
-8.55
Log(D) at pH=7.4
2.17
Log(P)
2.59
Log S
-3.96
Log(Vapor Pressure)
-8.02
Melting Point
148.12
pKa Acid
11.32
pKa Basic
5.83
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.9735
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.9735
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9568
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9568
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 3 0.9517
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 3 0.9517
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9493
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9493
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.9364
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 3 0.9364
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9347
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9347
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9204
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.9204
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9203
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.9203
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9181
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9181
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.9171
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.9171
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.9111
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.9111
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9106
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.9106
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9041
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9041
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9038
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9038
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9038
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9038
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9019
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9019
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9015
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.9015
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8998
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8998
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8979
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8979
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8966
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8966
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8934
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8934
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8902
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8902
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8891
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8891
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8834
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8834
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8833
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8833
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8825
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8825
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8783
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8783
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8770
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8770
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.8764
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 4 0.8764
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8711
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8711
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8708
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8708
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8696
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8696
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.8686
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.8686
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8672
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8672
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8655
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8655
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8655
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8655
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8646
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8646
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8629
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8629
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8599
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8599
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8585
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 3 0.8585
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8583
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8583
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8566
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8566
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.8559
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.8559
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8552
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8552
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8539
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8539
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8535
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8535
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8524
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8524
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8499
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8499
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.8494
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 3 0.8494
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8480
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8480
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.8460
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.8460
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8446
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8446
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8376
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8376
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8367
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8367
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8340
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8340
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8329
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8329
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8322
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8322
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8313
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8313
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8282
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8282
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8274
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8274
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.8251
Antitumor antibiotic C-1027 apoprotein Q06110 CAGA_STRGL Streptomyces globisporus 2 0.8251
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8241
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8241
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 3 0.8237
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 3 0.8237
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8220
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8220
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8213
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.8213
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8199
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8199
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.8196
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 3 0.8196
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8188
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8188
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8180
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8180
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 3 0.8152
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 3 0.8152
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8145
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8145
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8130
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8130
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8127
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8127
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8126
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8126
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8112
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8112
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8102
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.8102
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8097
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8097
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8097
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8097
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.8084
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 3 0.8084
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8078
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8078
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8064
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8064
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8064
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8064
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8062
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8062
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8057
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8057
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8044
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8044
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 3 0.8025
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 3 0.8025
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7996
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7996
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7988
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7988
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7982
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 3 0.7982
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7972
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7972
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7961
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7961
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7915
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7915
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7901
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7901
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7900
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7900
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7890
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7890
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7887
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7887
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7874
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7874
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7868
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7868
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7866
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7866
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7854
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.7854
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7850
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7850
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7849
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7849
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7844
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7844
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7844
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7844
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7844
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7844
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7842
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7842
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7841
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7841
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7821
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7821
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7812
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7812
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7804
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7804
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7799
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7799
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7782
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7782
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7778
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7778
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7774
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7774
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7773
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7773
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7769
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7769
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7764
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7764
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7757
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7757
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7755
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7755
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7753
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7753
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7745
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7745
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7742
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7742
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7733
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7733
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7724
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7724
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7723
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7723
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7716
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7716
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7710
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7710
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7697
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7697
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7694
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7694
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7694
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7694
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7689
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7689
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7675
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7675
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7673
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7673
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7673
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7673
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7662
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7662
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7661
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7661
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7656
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7656
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7656
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7656
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7649
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7649
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7646
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7646
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7645
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7645
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7645
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7645
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7644
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7644
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7642
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7642
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7641
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7641
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 2 0.7640
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7640
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 2 0.7640
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7640
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7633
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7633
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7632
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7632
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7627
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7627
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7624
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7624
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7621
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7621
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7617
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7617
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7615
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7615
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7612
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7612
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7608
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7608
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7602
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.7602
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7599
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7599
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7594
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7594
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7587
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7587
Protease O38708 O38708_9HIV1 Human immunodeficiency virus 1 3 0.7584
Protease O38708 O38708_9HIV1 Human immunodeficiency virus 1 3 0.7584
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7583
Abscisic acid receptor PYL1 Q8VZS8 PYL1_ARATH Arabidopsis thaliana 3 0.7583
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7580
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7580
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7575
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 4 0.7575
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7571
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 4 0.7571
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7569
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7569
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7569
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7569
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7566
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7566
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7563
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7563
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7554
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7554
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7552
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7552
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7552
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7552
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7550
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7550
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7549
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7549
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7548
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7548
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 3 0.7547
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 3 0.7547
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7546
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7546
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7544
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7544
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7542
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7542
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7540
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7540
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7537
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7537
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7534
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7534
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7533
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7533
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7532
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7532
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7528
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7528
Prostatic acid phosphatase P15309 PPAP_HUMAN Homo sapiens 2 0.7526
Prostatic acid phosphatase P15309 PPAP_HUMAN Homo sapiens 2 0.7526
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7517
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7517
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7512
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7512
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7510
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7510
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7506
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7506
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7503
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7503
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7502
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7502
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7502
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7502
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7494
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7494
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7492
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7492
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7492
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7492
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7484
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7484
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7481
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7481
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7479
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7479
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7478
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7478
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7471
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7471
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7458
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7458
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7458
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7458
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7453
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7453
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7453
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7453
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7451
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7451
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7446
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7446
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 4 0.7440
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 4 0.7440
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7439
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7439
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7437
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7437
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7435
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7435
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7435
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.7435
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 2 0.7428
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 2 0.7428
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7420
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7420
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7420
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7420
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7414
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7414
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7412
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7412
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7407
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7407
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7406
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7406
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7401
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7401
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7398
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7398
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7395
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7395
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7393
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7393
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7389
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7389
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7389
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.7389
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7387
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7387
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7382
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7382
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7379
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7379
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 MURB_ECOLI Escherichia coli 3 0.7379
UDP-N-acetylenolpyruvoylglucosamine reductase P08373 MURB_ECOLI Escherichia coli 3 0.7379
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7378
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7378
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7376
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 3 0.7376
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7372
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7372
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.7370
Ribosomal protein S6 kinase beta-1 P23443 KS6B1_HUMAN Homo sapiens 3 0.7370
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7369
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7369
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7368
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7368
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7367
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7367
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7366
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7365
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7365
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7364
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7364
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7362
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7362
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7360
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7360
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7358
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7358
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7358
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7358
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7357
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7357
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7355
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7355
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7355
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7355
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7351
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7351
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7349
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7349
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7347
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7347
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7334
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7334
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7333
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7333
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7332
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7332
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7329
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7329
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.7328
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.7328
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7320
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7320
Trichothecene 3-O-acetyltransferase O42692 O42692_GIBZA Gibberella zeae 4 0.7315
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7315
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7315
Trichothecene 3-O-acetyltransferase O42692 O42692_GIBZA Gibberella zeae 4 0.7315
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7314
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7314
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7310
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7310
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 2 0.7302
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 2 0.7302
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7293
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7293
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7290
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7290
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7288
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7288
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7281
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7281
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7278
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7278
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7277
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7277
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7277
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7277
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7275
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7275
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7269
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7269
Protein-tyrosine kinase 2-beta Q14289 FAK2_HUMAN Homo sapiens 4 0.7262
Protein-tyrosine kinase 2-beta Q14289 FAK2_HUMAN Homo sapiens 4 0.7262
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7261
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7261
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7260
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7260
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7258
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7258
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7257
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7257
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7251
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7251
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7251
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7251
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7248
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7248
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.7247
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.7247
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7243
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7243
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7243
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7243
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7243
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7243
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7236
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7236
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7232
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7232
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7232
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.7232
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7232
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7232
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7228
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7228
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7225
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7225
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7223
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7223
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7219
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7219
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7219
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7219
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7213
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 2 0.7213
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7209
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7209
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7207
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7207
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7201
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7201
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7197
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7197
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7197
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7197
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7194
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7194
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7190
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7190
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7185
Signaling protein P83820 P83820_THETH Thermus thermophilus 3 0.7185
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7185
Signaling protein P83820 P83820_THETH Thermus thermophilus 3 0.7185
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7183
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7183
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7183
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7183
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7183
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7183
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7180
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7180
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7177
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7177
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7176
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7176
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7167
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7167
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7167
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7167
Cystathionine beta-lyase MetC P06721 METC_ECOLI Escherichia coli 3 0.7166
Cystathionine beta-lyase MetC P06721 METC_ECOLI Escherichia coli 3 0.7166
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7159
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7159
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7159
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7159
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7159
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7159
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7158
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7158
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7155
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7155
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7155
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7155
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7154
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7154
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7152
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7152
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7149
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7149
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7148
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7148
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7146
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7146
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7144
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7144
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7143
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7143
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7140
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7140
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7139
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7139
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7134
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7134
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7133
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7133
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7132
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7132
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7130
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7128
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7128
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 2 0.7128
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 2 0.7128
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7127
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7127
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7125
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7125
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7125
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7125
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7124
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7124
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7123
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7123
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7122
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7122
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7117
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7117
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7112
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7112
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7112
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7112
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7109
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7109
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7106
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7106
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7102
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7102
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7100
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7100
Class B acid phosphatase P0AE22 APHA_ECOLI Escherichia coli 2 0.7100
Class B acid phosphatase P0AE22 APHA_ECOLI Escherichia coli 2 0.7100
Heat shock 70 kDa protein 1B P0DMV9 HS71B_HUMAN Homo sapiens 3 0.7099
Heat shock 70 kDa protein 1B P0DMV9 HS71B_HUMAN Homo sapiens 3 0.7099
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7099
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7099
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7097
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7097
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7088
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7088
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7085
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7085
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 4 0.7079
Myotonin-protein kinase Q09013 DMPK_HUMAN Homo sapiens 3 0.7079
Myotonin-protein kinase Q09013 DMPK_HUMAN Homo sapiens 3 0.7079
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 4 0.7079
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7078
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7078
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7076
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7076
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7076
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7076
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7073
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7073
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7068
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7068
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7067
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7067
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7062
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7062
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7061
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7061
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7060
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7060
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7059
Kelch-like ECH-associated protein 1 Q14145 KEAP1_HUMAN Homo sapiens 3 0.7059
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7055
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7055
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7051
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7051
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7051
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7051
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7050
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7050
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7048
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7048
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7045
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7045
Alanine racemase Q180W0 Q180W0_CLOD6 Clostridioides difficile 2 0.7044
Alanine racemase Q180W0 Q180W0_CLOD6 Clostridioides difficile 2 0.7044
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7043
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7043
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7041
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7041
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7039
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7039
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7039
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7039
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7037
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7037
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7035
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7035
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 3 0.7035
Mitogen-activated protein kinase 14 P47811 MK14_MOUSE Mus musculus 3 0.7035
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7033
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7033
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7032
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7032
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7025
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.7025
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.7025
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7025
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7023
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 3 0.7023
Purine nucleoside phosphorylase P50389 PNPH_SACS2 Saccharolobus solfataricus 3 0.7022
Purine nucleoside phosphorylase P50389 PNPH_SACS2 Saccharolobus solfataricus 3 0.7022
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7021
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7021
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7020
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7020
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7019
Cytochrome P450 3A4 P08684 CP3A4_HUMAN Homo sapiens 3 0.7019
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7018
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7018
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7017
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7017
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7017
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7017
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7017
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7017
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7013
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7013
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7012
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7012
Uncharacterized protein C7YVL8 C7YVL8_NECH7 Nectria haematococca 3 0.7009
Uncharacterized protein C7YVL8 C7YVL8_NECH7 Nectria haematococca 3 0.7009
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7006
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7006
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7002
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7002

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