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Julocrotine

Family: Plantae - Euphorbiaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Glutarimide Alkaloid

Canonical Smiles	CCC(C(=O)NC1CCC(=O)N(C1=O)CCc1ccccc1)C
InChI	InChI=1S/C18H24N2O3/c1-3-13(2)17(22)19-15-9-10-16(21)20(18(15)23)12-11-14-7-5-4-6-8-14/h4-8,13,15H,3,9-12H2,1-2H3,(H,19,22)
InChIKey	ASALPLLZVFIFMF-UHFFFAOYSA-N
Formula	C₁₈H₂₄N₂O₃
HBA	3
HBD	1
MW	316.4
Rotatable Bonds	6
TPSA	66.48
LogP	1.91
Number Rings	2
Number Aromatic Rings	1
Heavy Atom Count	23
Formal Charge	0
Fraction CSP3	0.5
Exact Mass	316.18
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Croton alienus	Euphorbiaceae	Plantae	100370

Showing of synonyms

Ndunda B, Langat MK, et al. (2013). Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.. Planta Med,2013,79(18),1762-1766. [View] [PubMed]

Pubchem: 12304733

Chebi: 68121

Nmrshiftdb2: 70070749

Metabolights: MTBLC68121

No compound-protein relationship available.

SMILES: c1ccccc1CCN2C(=O)CCCC2=O

Level: 1

Mol. Weight: 316.4 g/mol

SMILES: O=C1CCCC(=O)N1

Level: 0

Mol. Weight: 316.4 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 316.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.68
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.37
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.62

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.58
Plasma Protein Binding: 61.05
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.78
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.19
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.67
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 7.17
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 1.87
Rat (Acute): 2.91
Rat (Chronic Oral): 1.7
Fathead Minnow: 3.69
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 373.43
Hydration Free Energy: -9.84
Log(D) at pH=7.4: 2.16
Log(P): 2.27
Log S: -3.02
Log(Vapor Pressure): -6.7
Melting Point: 99.78
pKa Acid: 10.87
pKa Basic: 6.01

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9469
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9469
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	3	0.9269
Phosphotriesterase	Q5KZU5	Q5KZU5_GEOKA	Geobacillus kaustophilus	3	0.9269
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.9098
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.9098
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.9002
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.9002
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.8892
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.8892
BMP-2-inducible protein kinase	Q9NSY1	BMP2K_HUMAN	Homo sapiens	3	0.8776
BMP-2-inducible protein kinase	Q9NSY1	BMP2K_HUMAN	Homo sapiens	3	0.8776
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	3	0.8721
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	3	0.8721
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8715
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8715
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8702
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8702
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8656
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8656
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8604
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8604
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8574
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8574
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.8543
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.8543
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.8433
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.8433
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8250
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8250
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8170
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8170
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8161
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8161
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8119
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8119
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8057
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8057
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8039
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8039
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7997
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7997
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7993
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7993
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7929
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7929
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7908
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7908
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7892
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7892
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	3	0.7885
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	3	0.7885
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7867
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7867
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	2	0.7800
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	2	0.7800
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7799
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7799
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7777
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7777
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7762
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7762
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7702
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7702
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7686
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7686
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7686
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7686
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7685
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7685
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7679
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7679
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7675
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7675
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7664
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7664
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7663
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7663
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7657
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7657
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	2	0.7646
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	2	0.7646
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7623
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7623
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7623
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7623
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7611
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	2	0.7611
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7609
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7609
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7601
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7601
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7599
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7599
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7589
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.7589
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7583
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7583
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7575
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7575
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7575
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7575
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7558
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7558
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7551
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7551
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7550
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7550
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7550
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7550
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7544
7,8-dihydroneopterin aldolase	J7VEZ6	J7VEZ6_BACCE	Bacillus cereus BAG3X2-1	3	0.7544
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7537
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	2	0.7537
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7528
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7528
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7524
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	2	0.7524
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7521
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7521
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7519
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7519
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.7517
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.7517
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7483
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7483
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7479
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7479
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7477
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7477
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7475
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7475
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7458
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7458
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7456
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7456
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7455
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7455
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7446
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7446
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7442
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7442
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7441
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7441
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7439
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7439
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7436
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7436
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7435
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7435
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7426
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7426
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7411
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7411
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7409
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7409
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7405
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7405
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7396
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7396
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7376
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7376
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7373
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7373
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7364
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7364
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7360
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7360
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7347
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7347
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7347
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7347
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7344
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7344
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7327
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	2	0.7327
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7321
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7321
Abscisic acid receptor PYL9	Q84MC7	PYL9_ARATH	Arabidopsis thaliana	2	0.7320
Abscisic acid receptor PYL9	Q84MC7	PYL9_ARATH	Arabidopsis thaliana	2	0.7320
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7304
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7304
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7298
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7298
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7296
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7296
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7294
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	2	0.7294
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7288
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7288
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7282
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7282
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7277
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7277
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7275
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7275
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7275
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7275
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7274
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7274
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7273
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7273
Matrix metalloproteinase-20	O60882	MMP20_HUMAN	Homo sapiens	2	0.7268
Matrix metalloproteinase-20	O60882	MMP20_HUMAN	Homo sapiens	2	0.7268
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7268
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7268
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7262
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7262
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7260
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7260
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7255
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7255
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7253
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7253
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7246
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7246
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7238
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7238
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7231
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	2	0.7231
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7231
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	2	0.7231
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7230
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7230
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7229
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7229
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7227
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7227
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7226
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7226
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7225
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7225
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7223
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7223
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7221
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7221
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7218
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7218
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7216
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7216
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7215
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7215
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7213
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.7213
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7210
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7210
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7209
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7209
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7204
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7204
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7187
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7187
Regulatory protein SdiA	P07026	SDIA_ECOLI	Escherichia coli	3	0.7186
Regulatory protein SdiA	P07026	SDIA_ECOLI	Escherichia coli	3	0.7186
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7184
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7184
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7181
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7181
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	3	0.7180
SKP1-like protein 1A	Q39255	SKP1A_ARATH	Arabidopsis thaliana	3	0.7180
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7175
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7175
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7170
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7170
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	2	0.7163
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	2	0.7163
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7161
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7161
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7160
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7160
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7159
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7159
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7153
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7153
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7148
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7148
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7142
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7142
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	2	0.7139
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	2	0.7139
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7137
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7137
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7130
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7130
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7128
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7128
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7127
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7127
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7124
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	2	0.7124
Protease	O38708	O38708_9HIV1	Human immunodeficiency virus 1	3	0.7119
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7119
Protease	O38708	O38708_9HIV1	Human immunodeficiency virus 1	3	0.7119
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7119
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	2	0.7115
Threonine synthase 1, chloroplastic	Q9S7B5	THRC1_ARATH	Arabidopsis thaliana	2	0.7115
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7113
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7113
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7107
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7107
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7104
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.7104
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7103
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7103
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7102
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	2	0.7102
Nociceptin receptor	P41146	OPRX_HUMAN	Homo sapiens	3	0.7100
Nociceptin receptor	P41146	OPRX_HUMAN	Homo sapiens	3	0.7100
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7095
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7095
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.7093
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.7093
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7092
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7092
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7089
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7089
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7079
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7079
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7076
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7076
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7075
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7075
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7075
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7075
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7071
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7071
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7069
Glycoside Hydrolase Family 13	Q65MI2	Q65MI2_BACLD	Bacillus licheniformis	2	0.7069
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7064
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7064
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	2	0.7061
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	2	0.7061
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7050
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7050
Alanine racemase	Q180W0	Q180W0_CLOD6	Clostridioides difficile	2	0.7049
Alanine racemase	Q180W0	Q180W0_CLOD6	Clostridioides difficile	2	0.7049
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7048
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7048
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7039
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7039
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7038
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7038
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7034
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7034
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7030
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7030
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	2	0.7022
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	2	0.7022
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7014
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7014
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7014
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7014
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7012
Phenylpyruvate C(3)-methyltransferase	Q643C8	MPPJ_STRHY	Streptomyces hygroscopicus	2	0.7012
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7011
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7011

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