4'',5''-dihydro-5,2',4'-trihydroxy-5''-isopropenylfurano-(2'',3'';7,6)-isoflavanone - Compound Card

4'',5''-dihydro-5,2',4'-trihydroxy-5''-isopropenylfurano-(2'',3'';7,6)-isoflavanone

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4'',5''-dihydro-5,2',4'-trihydroxy-5''-isopropenylfurano-(2'',3'';7,6)-isoflavanone

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavanone
Canonical Smiles CC(=C)C1Oc2c(C1)c(O)c1c(c2)OCC(C1=O)c1ccc(cc1O)O
InChI InChI=1S/C20H18O6/c1-9(2)15-6-12-16(26-15)7-17-18(19(12)23)20(24)13(8-25-17)11-4-3-10(21)5-14(11)22/h3-5,7,13,15,21-23H,1,6,8H2,2H3
InChIKey MWILFHFRKVPOMC-UHFFFAOYSA-N
Formula C20H18O6
HBA 6
HBD 3
MW 354.36
Rotatable Bonds 2
TPSA 96.22
LogP 3.04
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 354.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Desmodium uncinatum Leguminosae/Fabaceae Plantae 225101
2 Desmodium uncinatum Leguminosae/Fabaceae Plantae 225101

Showing of synonyms

  • Guchu SM, Yenesew A, et al. (2007). C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum.. Phytochemistry,2007,68(5),646-651. [View] [PubMed]
  • Tsanuo MK, Hassanali A, et al. (2003). Isoflavanones from the allelopathic aqueous root exudate of Desmodium uncinatum. Phytochemistry,2003,64(1),265-273. [View] [PubMed]
Pubchem: 11089528
Nmrshiftdb2: 70093413

No compound-protein relationship available.

Structure

SMILES: C1COc(c12)cc3c(c2)C(=O)C(CO3)c4ccccc4

Level: 1

Mol. Weight: 266.3 g/mol

Structure

SMILES: C1COc(c12)cc3c(c2)C(=O)CCO3

Level: 0

Mol. Weight: 190.2 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.0
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.84
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.05

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.01
Plasma Protein Binding
57.05
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.09
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.14
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.29
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.62
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
0.09
Rat (Acute)
2.36
Rat (Chronic Oral)
2.77
Fathead Minnow
4.68
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
457.06
Hydration Free Energy
-10.05
Log(D) at pH=7.4
2.89
Log(P)
3.77
Log S
-5.42
Log(Vapor Pressure)
-9.26
Melting Point
205.05
pKa Acid
6.02
pKa Basic
5.14
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9426
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9426
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9130
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9130
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9079
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9079
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9072
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9072
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9011
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9011
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.9000
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.9000
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8992
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8992
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8985
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8985
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8955
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8955
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8787
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8787
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8763
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8763
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8657
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8657
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8646
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8646
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8529
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8529
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8468
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8468
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8463
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8463
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8410
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8410
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8405
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8405
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8403
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8403
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8388
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8388
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8293
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8293
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8252
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8252
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8250
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8250
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8179
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8179
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8137
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8137
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8094
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8094
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8064
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8064
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8053
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8053
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8035
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8035
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8032
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8032
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8016
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8016
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7975
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7975
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7900
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7900
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7896
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7896
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7862
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7862
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7794
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7794
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7767
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7767
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7766
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7766
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7753
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7753
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7682
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7682
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7667
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7667
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7662
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7662
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7655
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7655
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7629
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7629
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7607
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7607
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7601
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7601
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7593
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7593
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7591
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 3 0.7591
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7580
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7580
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7571
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7571
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7570
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7570
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7546
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7546
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7501
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7501
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7495
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7495
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7480
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7480
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7468
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7468
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7444
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7444
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7435
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7435
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7394
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7394
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7392
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7392
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7379
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7379
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7379
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7379
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7348
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7348
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7292
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7292
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7287
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7287
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7284
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7284
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7255
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7255
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7230
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7230
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7227
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7227
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7215
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7215
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7199
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7199
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7193
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7193
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7174
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7174
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7172
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7172
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7172
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7172
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7164
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7164
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7151
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7151
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7149
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7149
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7147
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7147
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7136
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7136
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7124
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7124
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7090
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7090
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7084
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7084
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7071
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7071
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7061
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7061
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7060
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7060
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7057
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7057
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7052
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7052
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7044
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7044
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7041
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7041
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7037
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7037
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7031
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7031
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7026
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7026
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7012
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7012
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7003
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7003
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7003
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7003

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