7,3'-dimethoxy-4',5'-methylenedioxyisoflavone - Compound Card

7,3'-dimethoxy-4',5'-methylenedioxyisoflavone

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7,3'-dimethoxy-4',5'-methylenedioxyisoflavone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1ccc2c(c1)OCC(C2=O)c1cc(OC)c2c(c1)OCO2
InChI InChI=1S/C18H16O6/c1-20-11-3-4-12-14(7-11)22-8-13(17(12)19)10-5-15(21-2)18-16(6-10)23-9-24-18/h3-7,13H,8-9H2,1-2H3
InChIKey CYGLYCANLBLSAD-UHFFFAOYSA-N
Formula C18H16O6
HBA 6
HBD 0
MW 328.32
Rotatable Bonds 3
TPSA 63.22
LogP 2.79
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.28
Exact Mass 328.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia dura Leguminosae/Fabaceae Plantae 62119

Showing of synonyms

  • Derese S, Yenesew A, et al. (2003). A new isoflavone from stem bark of Millettia dura. Bulletin of the Chemical Society of Ethiopia,2003,17(1),113-115. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)ccc(c2)C(C3=O)COc(c34)cccc4

Level: 1

Mol. Weight: 328.32 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 328.32 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 328.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.630
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.1

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.320
Plasma Protein Binding
64.39
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.240
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.340
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.800
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.710
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.780
Rat (Acute)
2.300
Rat (Chronic Oral)
1.610
Fathead Minnow
4.950
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
418.150
Hydration Free Energy
-7.620
Log(D) at pH=7.4
2.600
Log(P)
3.4
Log S
-4.19
Log(Vapor Pressure)
-7.04
Melting Point
109.76
pKa Acid
8.68
pKa Basic
1.27
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9827
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9827
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9816
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9816
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9603
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9603
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9492
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9492
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9477
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9477
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9400
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9400
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9205
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9205
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9170
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9170
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9150
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9150
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9089
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9089
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9077
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9077
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9000
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9000
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8974
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8974
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8908
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8908
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8857
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8857
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8815
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8815
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8780
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8780
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8754
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8754
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8717
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8717
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8628
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8628
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8535
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8535
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8514
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8514
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8513
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8513
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8494
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8494
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8463
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8463
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8403
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8403
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8354
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8354
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8327
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8327
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8260
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8260
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8248
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8248
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8225
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8225
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8152
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8152
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8146
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8146
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8133
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8133
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8132
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8132
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8082
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8082
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8042
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8042
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8018
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8018
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8008
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8008
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8008
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8008
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7972
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7972
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7941
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7941
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7893
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7893
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7882
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7882
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7877
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7877
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7866
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7866
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7857
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7857
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7854
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7854
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7852
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7852
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7844
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7844
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7820
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7820
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7787
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7787
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7777
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7777
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7775
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7775
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7728
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7728
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7724
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7724
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7709
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7709
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7707
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7707
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7704
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7704
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7699
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7699
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7693
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7693
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7690
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7690
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7660
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7660
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7652
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7652
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7646
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7646
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7641
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7641
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7640
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7640
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7601
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7601
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7599
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7599
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7585
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7585
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7584
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7584
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7554
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7554
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7547
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7547
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7539
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7539
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7537
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7537
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7522
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7522
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7513
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7513
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7484
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7484
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7451
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7451
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7450
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7450
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7411
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7411
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7408
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7408
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7408
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7408
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7389
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7389
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7380
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7380
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7374
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7374
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7359
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7359
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7354
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7354
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7340
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7340
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7338
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7338
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7326
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7326
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7305
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7305
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7304
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7304
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7300
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7300
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7296
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7296
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7293
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7293
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7291
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7291
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7289
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7289
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7288
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7288
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7277
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7277
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7270
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7270
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7268
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7268
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7266
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7266
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7262
Calmodulin-domain protein kinase 1, putative A3FQ16 A3FQ16_CRYPI Cryptosporidium parvum 3 0.7262
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7245
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7245
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7243
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7243
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7241
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7241
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7234
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7234
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7229
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7229
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7220
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7220
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7218
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7218
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7217
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7217
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7212
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7212
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7197
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7197
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7196
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7196
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7192
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7192
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7183
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7183
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7179
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7179
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7173
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7173
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7172
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7172
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7164
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7164
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7162
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7162
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7150
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7150
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7124
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7124
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7121
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7121
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7118
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7118
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7115
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7115
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7106
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7106
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7103
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7103
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7096
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7096
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7093
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7093
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7085
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7085
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7081
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7081
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7079
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7079
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7057
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7057
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7053
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7053
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7036
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7036
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7033
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7033
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7033
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7033
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7032
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7032
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7032
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7032
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7030
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7030
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7022
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7022
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7021
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7021
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7019
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7019
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7012
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7012
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7001
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7001
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7001
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7001

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