3-(3,4-dimethoxyphenyl)-8-(3-methylbut-2-enyl)-6-methoxy-7-hydroxybenzopyran-4-one - Compound Card

3-(3,4-dimethoxyphenyl)-8-(3-methylbut-2-enyl)-6-methoxy-7-hydroxybenzopyran-4-one

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3-(3,4-dimethoxyphenyl)-8-(3-methylbut-2-enyl)-6-methoxy-7-hydroxybenzopyran-4-one

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1cc2c(=O)c(coc2c(c1O)CC=C(C)C)c1ccc(c(c1)OC)OC
InChI InChI=1S/C23H24O6/c1-13(2)6-8-15-22(25)20(28-5)11-16-21(24)17(12-29-23(15)16)14-7-9-18(26-3)19(10-14)27-4/h6-7,9-12,25H,8H2,1-5H3
InChIKey GDLITRARWXLOEC-UHFFFAOYSA-N
Formula C23H24O6
HBA 6
HBD 1
MW 396.44
Rotatable Bonds 6
TPSA 78.13
LogP 4.7
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 29
Formal Charge 0
Fraction CSP3 0.26
Exact Mass 396.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia dura Leguminosae/Fabaceae Plantae 62119

Showing of synonyms

  • Yenesew A, Midiwo JO, et al. (1996). Four isoflavones from seed pods of Millettia dura. Phytochemistry,1996,41(3),951-955. [View] [PubMed]
Pubchem: 15292822
Nmrshiftdb2: 70035640

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 396.44 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 396.44 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 396.44 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.78
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.700
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.5

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.390
Plasma Protein Binding
83.08
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.350
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.950
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.090
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.790
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-11.920
Rat (Acute)
2.390
Rat (Chronic Oral)
2.050
Fathead Minnow
5.610
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
481.620
Hydration Free Energy
-6.020
Log(D) at pH=7.4
2.770
Log(P)
4.24
Log S
-5.05
Log(Vapor Pressure)
-8.17
Melting Point
155.63
pKa Acid
8.02
pKa Basic
4.98
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9582
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9582
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9512
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9512
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9502
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9502
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9495
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9495
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9483
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9483
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9481
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9481
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9453
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9453
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9413
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9413
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9327
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9327
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9161
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9161
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9100
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9100
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9059
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9059
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8992
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8992
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8967
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8967
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8953
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8953
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8874
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8874
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8872
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8872
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8819
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8819
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8798
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8798
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8700
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8700
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8684
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8684
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8649
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8649
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8644
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8644
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8613
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8613
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8573
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8573
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8567
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8567
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8557
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8557
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8465
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8465
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8278
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8278
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8272
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8272
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8267
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8267
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8265
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8265
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8175
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8175
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8172
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8172
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8144
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8144
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8122
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8122
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7997
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7997
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7997
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7997
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7993
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7993
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7957
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7957
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7931
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7931
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7891
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7891
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7889
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7889
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7881
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7881
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7870
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7870
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7853
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7853
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7831
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7831
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7829
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7829
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7815
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7815
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7791
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7791
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7759
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7759
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7758
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7758
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7742
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7742
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7716
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7716
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7713
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7713
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7713
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7713
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7696
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7696
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7688
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7688
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7686
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7686
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7681
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7681
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7677
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7677
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7663
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7663
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7657
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7657
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7646
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7646
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7631
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7631
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7626
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7626
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7616
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7616
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7615
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7615
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7597
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7597
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7595
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7595
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7595
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7595
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7575
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7575
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7569
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7569
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7538
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7538
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7535
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7535
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7533
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7533
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7532
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7532
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7529
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7529
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7510
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7510
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7497
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7497
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7489
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7489
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7481
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7481
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7474
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7474
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7471
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7471
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7468
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7468
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7463
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7463
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7451
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7451
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7428
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7428
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7416
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7416
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7409
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7409
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7406
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7406
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7405
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7405
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7396
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7396
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7393
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7393
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7388
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7388
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7388
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7388
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7377
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7377
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7366
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7366
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7362
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7362
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7357
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7357
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7356
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7356
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7345
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7345
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7345
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7345
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7344
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7344
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7333
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7333
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7330
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7330
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7322
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7322
Adenylosuccinate synthetase P0A7D4 PURA_ECOLI Escherichia coli 4 0.7310
Adenylosuccinate synthetase P0A7D4 PURA_ECOLI Escherichia coli 4 0.7310
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7310
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7310
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7307
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7307
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7296
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7296
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7296
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7296
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7296
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7296
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7286
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7286
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7286
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 4 0.7286
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7283
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7283
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7280
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7280
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7263
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7263
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7261
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7261
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7260
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7260
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7258
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7258
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7251
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7251
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7247
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7247
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7237
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7237
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7228
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7228
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7221
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7221
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7216
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7216
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7198
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7198
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7196
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7196
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7195
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7195
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7183
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7183
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7178
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7178
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7173
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7173
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7171
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7171
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7162
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7162
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7161
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7161
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7145
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7145
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7140
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7140
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7137
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7137
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7125
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7125
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7112
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7112
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7110
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7110
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7110
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7110
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7110
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7110
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7103
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7103
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7103
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7103
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7098
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7098
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7097
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7097
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.7092
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 4 0.7092
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7091
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7091
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7090
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7090
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7083
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7083
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7083
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7083
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7075
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7075
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7072
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7072
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7072
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7072
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7066
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7066
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7062
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7062
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7060
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7060
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7056
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7056
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7052
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7052
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7050
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7050
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7045
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7045
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7037
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7037
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7030
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7030
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7027
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7027
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7018
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7018
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7017
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7017
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7012
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7012
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7009
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7009

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