Calopocarpin - Compound Card

Calopocarpin

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Calopocarpin

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Pterocarpan
Canonical Smiles CC(=CCc1cc2c(cc1O)OC[C@@H]1[C@H]2Oc2c1ccc(c2)O)C
InChI InChI=1S/C20H20O4/c1-11(2)3-4-12-7-15-18(9-17(12)22)23-10-16-14-6-5-13(21)8-19(14)24-20(15)16/h3,5-9,16,20-22H,4,10H2,1-2H3/t16-,20-/m0/s1
InChIKey CYXCYFYWIZXENQ-JXFKEZNVSA-N
Formula C20H20O4
HBA 4
HBD 2
MW 324.38
Rotatable Bonds 2
TPSA 58.92
LogP 4.22
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.3
Exact Mass 324.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687
2 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687
3 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687
4 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687

Showing of synonyms

  • Yenesew A, Derese S, et al. (2005). Antimicrobial flavonoids from the stem bark of Erythrina burttii.. Fitoterapia,2005,76(5),469-472. [View] [PubMed]
  • Yenesew A, Akala HM, et al. (2012). The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii.. Acta Tropica,2012 Aug;123(2):123-127. [View] [PubMed]
  • Yenesew A, Midiwo JO, et al. (2002). Three isoflav-3-enes and a 2-arylbenzofuran from the root bark of Erythrina burttii.. Phytochemistry,2002,59(3),337-341. [View] [PubMed]
  • Yenesew A, Midiwo JO, et al. (1998). Two prenylated flavanones from stem bark of Erythrina burttii. Phytochemistry,1998,48(8),1489-1443. [View] [PubMed]
Pubchem: 11709595
Nmrshiftdb2: 60072156
Bindingdb: 50317436

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC3C2COc4c3cccc4

Level: 0

Mol. Weight: 324.38 g/mol

Anti-plasmodial
Antimicrobial

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.63
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.78

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.81
Plasma Protein Binding
85.56
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.72
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.68
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.79
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
6.08
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.76
Rat (Acute)
1.72
Rat (Chronic Oral)
1.92
Fathead Minnow
4.74
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
441.55
Hydration Free Energy
-9.19
Log(D) at pH=7.4
4.01
Log(P)
4.29
Log S
-4.65
Log(Vapor Pressure)
-9.03
Melting Point
205.54
pKa Acid
10.26
pKa Basic
7.02
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9422
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9422
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9316
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9316
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8896
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8896
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8889
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8889
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8858
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8858
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8612
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8612
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8557
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8557
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8544
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8544
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8516
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8516
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8477
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8477
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8461
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8461
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8290
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8290
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8227
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8227
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8212
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8212
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.8210
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.8210
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.8197
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.8197
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8190
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8190
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8172
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8172
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8138
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8138
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8130
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8130
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8118
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8118
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8104
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8104
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8089
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8089
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8075
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8075
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8066
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8066
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8037
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8037
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7991
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7991
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7949
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7949
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7829
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7829
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7788
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7788
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7787
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7787
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7784
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7784
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7717
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7717
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7708
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7708
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7705
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.7705
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7689
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7689
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7688
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7688
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7671
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7671
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7660
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7660
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7619
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7619
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7617
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7617
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7616
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7616
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7537
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.7537
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7524
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7524
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7509
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7509
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7498
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7498
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7497
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7497
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7480
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7480
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7475
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7475
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7471
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7471
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7459
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7459
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7458
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7458
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7431
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7431
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7402
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7402
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7402
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7402
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7389
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7389
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7386
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7386
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7384
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7384
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7325
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7325
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7319
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.7319
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7315
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7315
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7314
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7314
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7282
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7282
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7275
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7275
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7271
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7271
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7249
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7249
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7249
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7249
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7245
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7245
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7240
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7240
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7237
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7237
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7230
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7230
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7226
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7226
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7197
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7197
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7191
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7191
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7188
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7188
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7188
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7188
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7184
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7184
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7168
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7168
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7157
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7157
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7153
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7153
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7150
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7150
Inorganic pyrophosphatase Q3JUV5 Q3JUV5_BURP1 Burkholderia pseudomallei 2 0.7136
Inorganic pyrophosphatase Q3JUV5 Q3JUV5_BURP1 Burkholderia pseudomallei 2 0.7136
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7130
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7130
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7126
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7126
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7123
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7123
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7121
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7121
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7117
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7117
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7111
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7111
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7099
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7099
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7096
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7096
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7092
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7092
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7092
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7092
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7067
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7067
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7062
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7062
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7060
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7060
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7042
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7042
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7036
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7036
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7036
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7036
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7035
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7035
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7027
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7027
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7021
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7021
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7021
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7021
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7014
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7014
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7002
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7002

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