Isobavachalcone - Compound Card

Isobavachalcone

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Isobavachalcone

Structure
Zoomed Structure
  • Family: Plantae - Moraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Chalcone
Canonical Smiles CC(=CCc1c(O)ccc(c1O)C(=O)/C=C/c1ccc(cc1)O)C
InChI InChI=1S/C20H20O4/c1-13(2)3-9-16-19(23)12-10-17(20(16)24)18(22)11-6-14-4-7-15(21)8-5-14/h3-8,10-12,21,23-24H,9H2,1-2H3/b11-6+
InChIKey DUWPGRAKHMEPCM-IZZDOVSWSA-N
Formula C20H20O4
HBA 4
HBD 3
MW 324.38
Rotatable Bonds 5
TPSA 77.76
LogP 4.21
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.15
Exact Mass 324.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687
2 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687
3 Dorstenia kameruniana Moraceae Plantae 984812

Showing of synonyms

  • Abegaz BM, Ngadjui BT, et al. (1998). Prenylated chalcones and flavones from the leaves of dorstenia kameruniana. Phytochemistry, 1998, 49(4), 1147-1150. [View]
  • Yenesew A, Midiwo JO, et al. (2002). Three isoflav-3-enes and a 2-arylbenzofuran from the root bark of Erythrina burttii.. Phytochemistry,2002,59(3),337-341. [View] [PubMed]
  • Yenesew A, Midiwo JO, et al. (1998). Two prenylated flavanones from stem bark of Erythrina burttii. Phytochemistry,1998,48(8),1489-1443. [View] [PubMed]
Pubchem: 5281255
Kegg Ligand: C08648
Chebi: 28106
Nmrshiftdb2: 60026634
Metabolights: MTBLC28106
Bindingdb: 50441633
CPRiL: 60200
Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 324.38 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 324.38 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.69
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.69
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.84

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.9
Plasma Protein Binding
57.15
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.65
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.02
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.07
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.06
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.66
Rat (Acute)
2.0
Rat (Chronic Oral)
2.97
Fathead Minnow
4.9
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
438.82
Hydration Free Energy
-11.25
Log(D) at pH=7.4
3.75
Log(P)
5.11
Log S
-5.31
Log(Vapor Pressure)
-7.99
Melting Point
166.3
pKa Acid
7.58
pKa Basic
7.75
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9456
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9456
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9436
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9436
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9330
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.9330
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9163
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9163
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.9162
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 4 0.9162
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9108
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.9108
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9006
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9006
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8990
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8990
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8986
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8986
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8932
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8932
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8902
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8902
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8866
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8866
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8851
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8851
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8811
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8811
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8749
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8749
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8720
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8720
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8679
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8679
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8603
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8603
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8599
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8599
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8528
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8528
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8486
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8486
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8464
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8464
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8405
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8405
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8396
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8396
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8371
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8371
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8344
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8344
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8331
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.8331
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8293
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8293
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8286
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8286
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8283
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8283
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8267
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8267
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8232
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8232
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8221
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8221
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8162
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8162
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8153
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8153
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8153
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8153
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8140
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8140
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8093
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8093
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8064
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8064
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8055
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8055
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7968
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7968
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7967
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7967
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7936
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7936
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7934
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7934
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 4 0.7922
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 4 0.7922
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7919
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7919
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7913
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7913
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7866
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7866
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7800
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7800
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7799
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7799
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7785
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7785
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7783
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7783
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7779
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7779
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7773
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7773
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7761
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7761
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7734
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7734
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7723
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7723
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7720
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7720
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7704
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 3 0.7704
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7688
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7688
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7620
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7620
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7611
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7611
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7595
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7595
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7589
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7589
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7588
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7588
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7564
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.7564
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7563
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7563
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7549
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7549
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7536
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7536
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7531
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7531
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7529
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7529
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7515
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7515
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7513
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7513
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7509
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7509
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7504
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7504
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7500
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7500
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7489
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7489
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7483
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7483
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7475
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7475
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7473
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7473
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7456
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7456
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7454
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7454
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7426
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7426
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7415
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7415
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7409
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7409
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7403
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7403
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7402
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7402
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7397
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7397
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7392
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7392
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7386
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7386
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 5 0.7383
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 5 0.7383
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7381
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7381
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7372
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7372
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7353
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7353
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7353
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7353
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7350
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7350
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7347
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7347
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7347
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7347
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7342
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7342
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7336
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7336
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7334
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7334
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7315
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7315
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7312
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7312
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7311
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7311
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7299
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7299
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7289
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7289
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 4 0.7288
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 4 0.7288
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7280
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7280
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7279
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7279
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7258
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7258
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7255
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7255
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7254
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7254
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7252
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7252
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7247
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7247
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 3 0.7247
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7247
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7246
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7246
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7236
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7236
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7235
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7235
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 4 0.7234
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 4 0.7234
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7228
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7228
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7201
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7201
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7201
Formate--tetrahydrofolate ligase Q2RM91 FTHS_MOOTA Moorella thermoacetica 2 0.7201
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7187
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7187
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7185
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7185
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7177
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7177
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7168
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7168
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7159
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7159
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7158
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7158
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7157
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7157
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7141
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7141
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7123
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7123
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7121
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7121
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7112
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7112
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7109
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7109
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7105
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7105
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7104
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7104
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7103
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7103
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7098
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7098
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7092
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7092
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7085
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7085
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7081
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7081
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7079
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7079
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7078
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7078
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7070
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7070
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7064
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7064
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7060
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7060
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7060
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7060
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7057
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7057
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7043
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7043
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7037
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7037
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7032
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7032
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7024
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7024
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7021
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7021
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7020
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7020
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7020
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7020
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7019
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7019

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