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Bidwillol A

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavanone

Canonical Smiles	COc1c(ccc(c1CC=C(C)C)O)C1=Cc2c(OC1)cc(cc2)O
InChI	InChI=1S/C21H22O4/c1-13(2)4-7-18-19(23)9-8-17(21(18)24-3)15-10-14-5-6-16(22)11-20(14)25-12-15/h4-6,8-11,22-23H,7,12H2,1-3H3
InChIKey	CBCNITCGKSLSCT-UHFFFAOYSA-N
Formula	C₂₁H₂₂O₄
HBA	4
HBD	2
MW	338.4
Rotatable Bonds	4
TPSA	58.92
LogP	4.55
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.24
Exact Mass	338.15
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Erythrina burttii	Leguminosae/Fabaceae	Plantae	2590687

Showing of synonyms

Yenesew A, Midiwo JO, et al. (2002). Three isoflav-3-enes and a 2-arylbenzofuran from the root bark of Erythrina burttii.. Phytochemistry,2002,59(3),337-341. [View] [PubMed]

Pubchem: 10042759

Cas: 161099-42-9

Zinc: ZINC000014819466

Nmrshiftdb2: 60046407

No compound-protein relationship available.

SMILES: c1cccc(c12)OCC(=C2)c3ccccc3

Level: 1

Mol. Weight: 338.4 g/mol

SMILES: C1=CCOc(c12)cccc2

Level: 0

Mol. Weight: 338.4 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 338.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.74
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.650
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.92

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.000
Plasma Protein Binding: 48.21
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.110
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.620
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.650
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.930
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.540
Rat (Acute): 1.940
Rat (Chronic Oral): 2.460
Fathead Minnow: 5.070
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 440.270
Hydration Free Energy: -9.750
Log(D) at pH=7.4: 3.870
Log(P): 5.15
Log S: -5.68
Log(Vapor Pressure): -7.67
Melting Point: 164.81
pKa Acid: 10.19
pKa Basic: 7.25

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9589
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.9589
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9533
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9533
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9480
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9480
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9449
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9449
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9449
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9449
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9424
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9424
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9403
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9403
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9378
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9378
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9317
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9317
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9285
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9285
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.9127
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.9127
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9124
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9124
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.9057
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	4	0.9057
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8987
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8987
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8721
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8721
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.8702
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.8702
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.8668
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8668
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8668
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.8668
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8632
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8632
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8572
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8572
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8551
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8551
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8544
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8544
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8532
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8532
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8522
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8522
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8511
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8511
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.8490
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	3	0.8490
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8487
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.8487
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8485
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8485
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8465
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8465
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8376
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8376
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.8330
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.8330
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8275
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8275
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8192
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8192
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	5	0.8176
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	5	0.8176
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8135
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8135
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.8119
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.8119
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8080
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8080
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8058
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.8058
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.8016
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.8016
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8006
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8006
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7986
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7986
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.7978
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	F6MZ55	F6MZ55_9FIRM	Sporomusa ovata	3	0.7978
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7974
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7974
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7909
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7909
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7894
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.7894
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7856
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7856
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7845
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7845
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7824
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7824
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7798
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7798
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7790
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7790
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.7778
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.7778
Troponin C, slow skeletal and cardiac muscles	P63316	TNNC1_HUMAN	Homo sapiens	4	0.7747
Troponin C, slow skeletal and cardiac muscles	P63316	TNNC1_HUMAN	Homo sapiens	4	0.7747
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7719
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7719
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7712
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7712
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7695
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7695
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7676
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7676
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7675
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7675
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7669
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7669
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7667
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7667
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7662
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7662
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7642
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7642
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7637
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7637
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7604
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7604
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7586
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7586
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7547
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7547
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7543
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7543
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7519
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7519
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7492
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7492
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7490
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7490
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7473
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7473
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7452
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.7452
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7451
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7451
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7435
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7435
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7418
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7418
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7418
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7418
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7407
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7407
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7403
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7403
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7393
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7393
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7390
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7390
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7386
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7386
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7384
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7384
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7375
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7375
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7345
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7345
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7340
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7340
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7335
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7335
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.7335
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7335
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7328
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7328
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7326
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7326
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7323
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7323
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7317
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7317
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7307
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7307
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7299
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7299
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7275
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7275
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7275
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7275
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7271
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7271
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7266
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7266
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7250
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7250
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7237
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7237
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7232
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7232
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7230
Acyl-CoA:acyl-CoA alkyltransferase	Q8PDX2	OLEA_XANCP	Xanthomonas campestris pv. campestris	3	0.7230
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7221
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7221
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7220
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7220
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	2	0.7213
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	2	0.7213
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7208
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7208
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7206
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7206
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7205
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7205
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7202
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7202
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7196
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7196
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7194
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7194
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7182
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7182
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7171
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7171
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7171
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7171
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7169
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7169
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7157
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7157
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7156
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7156
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7151
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7151
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7147
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	2	0.7147
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7136
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7136
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7117
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7117
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7116
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7116
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7110
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7110
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7104
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7104
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7100
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7100
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7094
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7094
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7083
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7083
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7080
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7080
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7071
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7071
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7069
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7069
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7055
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7055
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7055
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7055
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7050
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7050
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7042
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7042
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7034
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7034
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7030
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7030
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7029
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7029
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7016
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7016
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7015
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7015
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	2	0.7011
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	2	0.7011
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7007
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7007

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