5,7-dihydroxy-4'-methoxy-3'-(3-methylbutadienyl)-5'-(3-methylbut-2-enyl)flavanone - Compound Card

5,7-dihydroxy-4'-methoxy-3'-(3-methylbutadienyl)-5'-(3-methylbut-2-enyl)flavanone

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5,7-dihydroxy-4'-methoxy-3'-(3-methylbutadienyl)-5'-(3-methylbut-2-enyl)flavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles COc1c(CC=C(C)C)cc(cc1/C=C/C(=C)C)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O
InChI InChI=1S/C26H28O5/c1-15(2)6-8-17-10-19(11-18(26(17)30-5)9-7-16(3)4)23-14-22(29)25-21(28)12-20(27)13-24(25)31-23/h6-8,10-13,23,27-28H,1,9,14H2,2-5H3/b8-6+/t23-/m0/s1
InChIKey NCRSCUAICIRLHP-DRGXBFSJSA-N
Formula C26H28O5
HBA 5
HBD 2
MW 420.51
Rotatable Bonds 6
TPSA 75.99
LogP 5.91
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 31
Formal Charge 0
Fraction CSP3 0.27
Exact Mass 420.19
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687

Showing of synonyms

  • Yenesew A, Irungu B, et al. (2003). Two prenylated flavonoids from the stem bark of Erythrina burttii.. Phytochemistry,2003,63(4),445-448. [View] [PubMed]
Pubchem: 12098451
Nmrshiftdb2: 70057975
Bindingdb: 50274993

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 420.51 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 420.51 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 420.51 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.79
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.750
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.24

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.350
Plasma Protein Binding
85.93
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.000
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.890
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.430
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.500
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-26.970
Rat (Acute)
2.040
Rat (Chronic Oral)
3.120
Fathead Minnow
5.380
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
473.420
Hydration Free Energy
-5.060
Log(D) at pH=7.4
4.240
Log(P)
6.65
Log S
-7.39
Log(Vapor Pressure)
-8.89
Melting Point
170.23
pKa Acid
9.07
pKa Basic
6.16
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9490
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9490
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9447
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9447
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9271
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9271
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9248
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9248
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9065
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9065
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8957
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8957
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8955
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8955
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8946
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8946
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8878
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8878
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8816
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8816
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8796
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8796
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8718
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8718
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8717
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8717
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8696
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8696
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8691
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8691
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8680
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8680
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8645
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8645
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8616
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8616
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8612
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8612
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8594
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8594
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8562
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8562
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8556
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8556
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8543
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8543
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8538
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8538
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8537
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8537
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8529
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8529
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8478
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8478
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8447
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8447
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8360
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8360
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8306
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8306
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8289
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8289
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8272
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8267
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8267
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8258
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8258
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8250
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8250
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8230
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8230
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8215
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8215
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8191
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8191
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8187
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8187
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8151
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8151
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8151
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8151
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8135
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8135
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8132
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8132
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.8102
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.8102
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8094
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8094
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8090
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8090
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8062
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8062
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8032
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8032
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8005
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8005
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8000
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8000
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7982
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7982
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7972
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7972
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7962
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7962
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7951
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7951
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7910
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7910
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7900
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7900
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7843
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7843
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7830
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7830
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7812
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7812
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7800
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7800
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7800
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7800
DNA double-strand break repair protein Mre11 Q9X1X0 Q9X1X0_THEMA Thermotoga maritima MSB8 4 0.7781
DNA double-strand break repair protein Mre11 Q9X1X0 Q9X1X0_THEMA Thermotoga maritima MSB8 4 0.7781
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7779
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7779
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7754
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7754
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7753
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7753
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7740
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7740
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7718
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7718
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7715
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7715
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7685
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7685
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7684
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7684
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7683
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7683
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7645
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7645
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7635
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7635
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7599
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7599
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7594
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7594
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7584
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7584
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7562
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7562
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7562
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7562
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7558
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7558
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7544
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7544
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7540
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7540
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7531
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7531
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7531
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7531
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7511
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7511
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7504
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7504
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7491
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7491
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7468
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7468
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7462
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7462
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7460
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7460
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7441
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7441
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7439
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7439
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7438
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7438
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7434
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7434
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7421
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7421
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7418
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7418
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7417
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7417
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7412
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7412
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7409
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7409
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7405
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7405
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7398
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7398
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7388
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7388
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7384
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7384
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7381
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7381
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7370
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7370
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7370
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7370
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7367
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7367
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7351
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7351
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7340
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7340
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7337
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7337
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7336
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7336
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7331
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7331
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7323
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7323
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7323
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7323
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7322
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7322
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7321
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7321
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7320
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7320
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7317
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7317
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7298
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7298
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7282
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7282
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7280
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7280
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7278
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7278
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7267
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7267
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7264
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7264
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7263
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7263
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7253
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7253
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7245
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7245
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7243
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7243
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7235
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7235
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7232
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7232
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7229
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7229
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7215
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7215
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7215
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7215
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7215
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7215
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7214
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7214
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7214
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7214
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7208
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7208
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7191
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7191
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7188
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7188
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7186
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7186
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7182
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7182
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7179
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7179
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7179
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7179
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7173
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7173
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7157
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7157
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7154
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7154
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7153
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7153
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7152
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7152
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7145
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7145
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7144
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7144
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7141
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7141
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7140
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7140
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7138
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7138
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7134
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7134
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7133
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7133
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7131
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7131
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7126
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7126
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7119
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7119
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7116
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7116
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7111
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7111
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7108
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7108
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7096
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7096
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7087
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7087
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7083
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7083
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7079
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7079
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7077
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7077
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7072
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7072
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7043
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7043
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7042
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7042
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7042
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7042
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7021
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7021
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7021
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7021
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7018
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7018
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7014
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7014
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7011
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7011
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7011
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7011
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7010
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7010
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7000
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7000

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