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3-O-methylcalopocarpin

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavonoid

Canonical Smiles	COc1cc2OC[C@@H]3[C@H](c2cc1CC=C(C)C)Oc1c3ccc(c1)O
InChI	InChI=1S/C21H22O4/c1-12(2)4-5-13-8-16-19(10-18(13)23-3)24-11-17-15-7-6-14(22)9-20(15)25-21(16)17/h4,6-10,17,21-22H,5,11H2,1-3H3/t17-,21-/m0/s1
InChIKey	FZFGGNNUYSILSL-UWJYYQICSA-N
Formula	C₂₁H₂₂O₄
HBA	4
HBD	1
MW	338.4
Rotatable Bonds	3
TPSA	47.92
LogP	4.52
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.33
Exact Mass	338.15
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Erythrina burttii	Leguminosae/Fabaceae	Plantae	2590687
2	Erythrina schliebenii	Leguminosae/Fabaceae	Plantae	2590720

Showing of synonyms

Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
Yenesew A, Irungu B, et al. (2003). Two prenylated flavonoids from the stem bark of Erythrina burttii.. Phytochemistry,2003,63(4),445-448. [View] [PubMed]

Pubchem: 467497

Chebi: 66369

Nmrshiftdb2: 60046530

Metabolights: MTBLC66369

Chembl: CHEMBL465985

No compound-protein relationship available.

SMILES: c1cccc(c12)OC3C2COc4c3cccc4

Level: 0

Mol. Weight: 338.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.82
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.550
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.57

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.220
Plasma Protein Binding: 89.45
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.510
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.970
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.150
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 6.760
Micronucleos: Safe
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: 0.150
Rat (Acute): 1.890
Rat (Chronic Oral): 2.200
Fathead Minnow: 5.110
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 439.170
Hydration Free Energy: -6.980
Log(D) at pH=7.4: 3.970
Log(P): 4.97
Log S: -5.82
Log(Vapor Pressure): -7.83
Melting Point: 153.58
pKa Acid: 10.44
pKa Basic: 7.02

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9541
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9541
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9481
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9481
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.9224
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.9224
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9107
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9107
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8982
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8982
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8937
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8937
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8815
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8815
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8639
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8639
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8634
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8634
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8575
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8575
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8574
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8574
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8543
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8543
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8542
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8542
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.8517
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.8517
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	3	0.8462
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	3	0.8462
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.8417
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8417
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.8417
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8417
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8414
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8414
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8360
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.8360
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.8353
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.8353
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8345
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8345
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.8325
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.8325
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8299
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8299
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.8296
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.8296
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.8265
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.8265
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8257
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8257
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8240
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8240
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8237
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8237
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8184
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8184
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.8177
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.8177
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.8174
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.8174
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.8158
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.8158
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8156
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8156
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8104
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8104
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8033
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8033
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.8014
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.8014
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8009
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8009
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.8003
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.8003
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7977
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7977
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.7976
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.7976
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7915
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.7915
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7876
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7876
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7852
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7852
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7758
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7758
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7741
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7741
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7722
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7722
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7712
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7712
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7696
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7696
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7690
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7690
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7684
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7684
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	4	0.7684
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7684
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7672
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7672
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7663
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7663
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7660
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7660
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7657
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7657
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7637
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7637
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7611
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7611
Cellular retinol-binding protein type II	Q8UVG6	Q8UVG6_DANRE	Danio rerio	3	0.7604
Cellular retinol-binding protein type II	Q8UVG6	Q8UVG6_DANRE	Danio rerio	3	0.7604
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.7599
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.7599
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7567
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7567
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7555
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7555
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7553
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7553
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7550
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7550
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7530
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7530
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7526
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7526
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7526
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7526
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7523
Dihydrofolate reductase	P16184	DYR_PNECA	Pneumocystis carinii	3	0.7523
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7509
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7509
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7506
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7506
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7490
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7490
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7468
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7468
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7458
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7458
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7454
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7454
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7450
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7450
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7447
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7447
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7422
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7422
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7421
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.7421
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7408
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7408
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7396
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7396
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7391
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7391
Dihydrofolate reductase	O30463	O30463_MYCAV	Mycobacterium avium	3	0.7385
Dihydrofolate reductase	O30463	O30463_MYCAV	Mycobacterium avium	3	0.7385
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7378
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7378
Japanin	M1MR49	M1MR49_RHIAP	Rhipicephalus appendiculatus	3	0.7376
Japanin	M1MR49	M1MR49_RHIAP	Rhipicephalus appendiculatus	3	0.7376
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7371
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	4	0.7371
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7368
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7368
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7363
Ribosome-inactivating protein alpha-trichosanthin	P09989	RIPT_TRIKI	Trichosanthes kirilowii	3	0.7363
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7362
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	3	0.7362
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	3	0.7358
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	3	0.7358
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7353
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7353
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	2	0.7332
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	2	0.7332
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7322
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7322
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7310
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7310
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7307
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7307
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7302
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7302
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7290
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7290
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7276
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7276
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7270
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7270
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7268
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7268
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	3	0.7265
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	3	0.7265
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7257
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7257
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7248
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7248
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7247
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7247
Cytidylate kinase	Q5SL35	KCY_THET8	Thermus thermophilus	3	0.7236
Cytidylate kinase	Q5SL35	KCY_THET8	Thermus thermophilus	3	0.7236
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7225
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7225
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7210
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7210
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7207
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7207
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7204
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7204
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7204
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7204
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7202
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7202
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7200
Cyclic GMP-AMP phosphodiesterase SMPDL3A	Q92484	ASM3A_HUMAN	Homo sapiens	2	0.7200
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7196
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7196
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7193
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7193
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7191
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7191
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7187
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7187
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7187
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7187
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7170
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7170
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7167
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7167
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7166
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7166
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7158
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7158
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7157
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7157
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7156
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7156
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7146
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7146
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7145
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7145
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7143
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7143
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.7140
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.7140
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7116
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7116
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7115
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	2	0.7115
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7110
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7110
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7100
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7100
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7098
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.7098
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7098
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.7098
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.7098
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7098
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7095
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7095
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7094
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7094
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7092
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7092
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7088
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7088
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7079
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7079
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7072
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7072
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7071
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7071
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7069
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7069
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7065
Holliday junction branch migration complex subunit RuvB	Q9PMT7	RUVB_CAMJE	Campylobacter jejuni subsp. jejuni serotype O:2	2	0.7065
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7063
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7063
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7050
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7050
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7050
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.7050
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7049
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7049
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7047
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7047
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7045
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7045
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.7041
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.7041
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7040
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7040
Dihydrofolate reductase	Q83AB2	Q83AB2_COXBU	Coxiella burnetii	3	0.7034
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7034
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7034
Dihydrofolate reductase	Q83AB2	Q83AB2_COXBU	Coxiella burnetii	3	0.7034
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7026
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7026
Phosphatidylinositol 3-kinase catalytic subunit type 3	Q8NEB9	PK3C3_HUMAN	Homo sapiens	4	0.7019
Phosphatidylinositol 3-kinase catalytic subunit type 3	Q8NEB9	PK3C3_HUMAN	Homo sapiens	4	0.7019
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7017
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7017
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7016
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7016
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7015
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7015
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7008
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7008
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7005
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7005
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7003
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7003
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7001
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7001
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7001
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7001
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7000
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7000

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