Sigmoidin B 4'-methylether diacetate - Compound Card

Sigmoidin B 4'-methylether diacetate

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Sigmoidin B 4'-methylether diacetate

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles COc1c(CC=C(C)C)cc(cc1OC(=O)C)C1CC(=O)c2c(O1)cc(cc2O)OC(=O)C
InChI InChI=1S/C25H26O8/c1-13(2)6-7-16-8-17(9-23(25(16)30-5)32-15(4)27)21-12-20(29)24-19(28)10-18(31-14(3)26)11-22(24)33-21/h6,8-11,21,28H,7,12H2,1-5H3
InChIKey JXQCCWXKPJFXTC-UHFFFAOYSA-N
Formula C25H26O8
HBA 8
HBD 1
MW 454.48
Rotatable Bonds 6
TPSA 108.36
LogP 4.47
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 33
Formal Charge 0
Fraction CSP3 0.32
Exact Mass 454.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina burttii Leguminosae/Fabaceae Plantae 2590687

Showing of synonyms

  • Yenesew A, Derese S, et al. (2005). Antimicrobial flavonoids from the stem bark of Erythrina burttii.. Fitoterapia,2005,76(5),469-472. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 224.26 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 148.16 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-4.66
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.620
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.06

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.150
Plasma Protein Binding
50.73
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.600
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.780
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.140
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
8.030
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-67.740
Rat (Acute)
2.170
Rat (Chronic Oral)
2.610
Fathead Minnow
5.390
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
480.630
Hydration Free Energy
-2.870
Log(D) at pH=7.4
3.470
Log(P)
4.55
Log S
-6.56
Log(Vapor Pressure)
-8.67
Melting Point
149.06
pKa Acid
8.67
pKa Basic
5.0
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9451
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9451
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9405
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9405
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9263
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9263
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9186
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9186
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8985
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8985
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8958
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8958
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8895
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8895
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8888
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8888
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8750
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8750
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8742
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8742
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8739
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8739
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8712
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8712
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8672
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8672
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8661
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8661
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8610
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8610
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8599
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8599
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8576
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8576
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8537
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8537
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8494
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8494
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8482
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8482
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8457
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8457
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8454
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8454
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8407
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8407
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8401
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8401
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8371
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8371
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8301
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8301
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8155
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8155
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8128
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8128
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8091
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8091
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8065
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8065
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8062
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8062
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8000
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8000
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8000
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8000
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7981
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7981
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7940
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7940
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7920
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7920
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7918
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7918
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7902
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7902
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7898
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7898
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7868
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7868
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7868
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7868
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7850
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7850
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7840
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7840
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7837
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7837
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7822
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7822
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7819
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7819
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7767
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7767
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7761
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7761
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7754
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7754
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7735
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7735
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7732
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7732
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7730
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7730
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7723
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7723
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7661
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7661
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7654
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7654
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7606
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7606
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7594
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7594
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7584
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7584
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7576
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7576
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7568
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7568
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7566
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7566
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7549
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7549
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7533
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7533
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7526
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7526
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7525
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7525
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7518
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7518
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7514
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7514
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7495
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7495
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7480
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7480
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7478
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7478
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 4 0.7451
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 4 0.7451
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7437
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7437
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7427
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7427
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7420
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7420
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7401
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7401
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7400
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7400
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7377
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7377
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7370
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7370
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7369
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7369
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7362
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7362
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7347
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7347
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7336
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7336
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7329
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7329
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7327
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7327
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7323
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7323
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7319
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7319
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7308
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7308
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7305
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7305
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7304
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7304
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7296
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7296
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7293
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7293
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.7283
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.7283
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7273
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7273
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7270
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7270
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7270
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7270
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7268
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7268
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7260
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7260
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7255
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7255
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7253
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7253
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7251
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7251
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7249
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7249
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7249
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7249
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7227
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7227
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7221
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7221
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7212
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7212
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7206
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7206
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7198
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7198
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7197
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7197
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7187
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7187
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7176
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7176
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7174
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7174
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7173
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7173
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7167
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7167
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7160
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7160
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7158
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7158
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7157
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7157
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7148
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7148
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7147
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7147
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7131
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7131
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7128
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7128
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7118
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7118
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7118
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7118
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7115
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7115
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7112
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7112
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7098
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7098
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7096
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7096
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7095
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7095
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7089
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7089
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7087
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7087
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7086
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7086
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7080
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7080
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7075
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7075
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7072
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7072
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7053
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7053
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7047
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 3 0.7047
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7045
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7045
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7039
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7039
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7029
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7029
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7023
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7023
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7022
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7022
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7015
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7015
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7014
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7014
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7012
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7012
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7011
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7011
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7011
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7011
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7010
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7010
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7006
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7006
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7002
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7002

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