(R)-5,7-dihydroxy-2',4',5'-trimethoxyisoflavanone - Compound Card

(R)-5,7-dihydroxy-2',4',5'-trimethoxyisoflavanone

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(R)-5,7-dihydroxy-2',4',5'-trimethoxyisoflavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavonoid
Canonical Smiles COc1cc(OC)c(cc1[C@@H]1COc2c(C1=O)c(O)cc(c2)O)OC
InChI InChI=1S/C18H18O7/c1-22-13-7-15(24-3)14(23-2)6-10(13)11-8-25-16-5-9(19)4-12(20)17(16)18(11)21/h4-7,11,19-20H,8H2,1-3H3/t11-/m0/s1
InChIKey DWYGHGCLIOYRFR-NSHDSACASA-N
Formula C18H18O7
HBA 7
HBD 2
MW 346.34
Rotatable Bonds 4
TPSA 94.45
LogP 2.48
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.28
Exact Mass 346.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina sacleuxii Leguminosae/Fabaceae Plantae 1899109
2 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
  • Yenesew A, Midiwo JO, et al. (2000). Two isoflavanones from the stem bark of Erythrina sacleuxii.. Phytochemistry,2000,55(5),457-459. [View] [PubMed]
Pubchem: 12971610
Nmrshiftdb2: 60073002

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OCC(C2=O)c3ccccc3

Level: 1

Mol. Weight: 346.34 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 346.34 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 346.34 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.56
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.800
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.02

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.100
Plasma Protein Binding
71.45
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.490
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.520
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.940
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.190
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.560
Rat (Acute)
2.010
Rat (Chronic Oral)
2.730
Fathead Minnow
4.650
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
432.930
Hydration Free Energy
-9.080
Log(D) at pH=7.4
2.930
Log(P)
2.69
Log S
-5.93
Log(Vapor Pressure)
-7.67
Melting Point
178.14
pKa Acid
7.37
pKa Basic
3.12
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9416
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9416
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9312
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9312
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9267
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9267
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9209
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9209
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9101
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9101
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8999
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8999
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8963
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8963
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8897
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8897
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8892
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8892
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8843
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8843
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8827
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8827
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8817
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8817
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8675
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8675
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8661
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8661
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8647
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8647
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8646
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.8646
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8644
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8644
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8632
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8632
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8613
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8613
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8581
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8581
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8577
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8577
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8537
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8537
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8523
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8523
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8517
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8517
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8489
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8489
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.8453
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 4 0.8453
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8450
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8450
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8446
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8446
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8407
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8407
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8365
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8365
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8347
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8347
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8315
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8315
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8302
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8302
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8228
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8228
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8189
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8189
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8178
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8178
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8159
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8159
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8154
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8154
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8124
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8124
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8102
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8102
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8098
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8098
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8095
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8095
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8089
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8089
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8070
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8070
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8059
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8059
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8033
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8033
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8007
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8007
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7998
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7998
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7964
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7964
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7933
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7933
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7917
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7917
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7915
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7915
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7852
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7852
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7841
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7841
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7836
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7836
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7809
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7809
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7788
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7788
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7771
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7771
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7765
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7765
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7757
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7757
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7745
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7745
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7744
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7744
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7725
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7725
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7721
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7721
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7718
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7718
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7703
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7703
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7698
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7698
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7646
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7646
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7635
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7635
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7622
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7622
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7618
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7618
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7605
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7605
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7586
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7586
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7580
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7580
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7569
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7569
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7562
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7562
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7550
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7550
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7539
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7539
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7536
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7536
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7536
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7536
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7535
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7535
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7520
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7520
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7517
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7517
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7516
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7516
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7511
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7511
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7510
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7510
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7504
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7504
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7493
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7493
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7488
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7488
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7484
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7484
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7477
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7477
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7475
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7475
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7451
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7451
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7446
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7446
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7425
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7425
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7408
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7408
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7403
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7403
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7389
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7389
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7381
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7381
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7381
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7381
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7377
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7377
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7360
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7360
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7359
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7359
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7359
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7359
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7359
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7359
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7357
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7357
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7350
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7350
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7345
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7345
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7331
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7331
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7323
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7323
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7312
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7312
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7310
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7310
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7310
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7310
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7305
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7305
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7300
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7300
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7269
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7269
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7268
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7268
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7265
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7265
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7254
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7254
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7252
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7252
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7245
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7245
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7238
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7238
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7234
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7234
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7228
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7228
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7211
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7211
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7210
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7210
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7207
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7207
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7192
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7192
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7174
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7174
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7162
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7162
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7146
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7146
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7145
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7145
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7139
Dipeptidyl peptidase 4 P22411 DPP4_PIG Sus scrofa 3 0.7139
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7136
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7136
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7136
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7136
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7133
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7133
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7130
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7130
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7126
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7126
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7117
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7117
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7116
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7116
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7115
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7115
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7115
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7115
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7111
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7111
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7094
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7094
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7089
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7089
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7083
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7083
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7080
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7080
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7073
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7073
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7059
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7059
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7059
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7059
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7058
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7058
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7057
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7057
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7056
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7056
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7053
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7053
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7036
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7036
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7030
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 4 0.7030
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7018
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7018
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7009
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7009
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7007
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7007
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7005
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7005
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7003
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7003
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7001
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7001
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7000
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7000

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