2,3-dehydrokievitone - Compound Card

2,3-dehydrokievitone

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2,3-dehydrokievitone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles CC(=CCc1c(O)cc(c2c1occ(c2=O)c1ccc(cc1O)O)O)C
InChI InChI=1S/C20H18O6/c1-10(2)3-5-13-16(23)8-17(24)18-19(25)14(9-26-20(13)18)12-6-4-11(21)7-15(12)22/h3-4,6-9,21-24H,5H2,1-2H3
InChIKey RWDSADRZXTYPMY-UHFFFAOYSA-N
Formula C20H18O6
HBA 6
HBD 4
MW 354.36
Rotatable Bonds 3
TPSA 111.13
LogP 3.79
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.15
Exact Mass 354.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina sacleuxii Leguminosae/Fabaceae Plantae 1899109
2 Erythrina sacleuxii Leguminosae/Fabaceae Plantae 1899109

Showing of synonyms

  • Andayi AW, Yenesew A, et al. (2006). Antiplasmodial flavonoids from Erythrina sacleuxii.. Planta Medica,2006,72(2),187-189. [View] [PubMed]
  • Yenesew A, Midiwo JO, et al. (2000). Two isoflavanones from the stem bark of Erythrina sacleuxii.. Phytochemistry,2000,55(5),457-459. [View] [PubMed]
Pubchem: 5746354
Chebi: 175549
Nmrshiftdb2: 60066115

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 354.36 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 354.36 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 354.36 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-5.5
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.02
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.56

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.08
Plasma Protein Binding
85.62
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.31
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.23
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.03
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.53
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.64
Rat (Acute)
2.43
Rat (Chronic Oral)
3.1
Fathead Minnow
4.84
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
490.65
Hydration Free Energy
-11.29
Log(D) at pH=7.4
3.35
Log(P)
4.51
Log S
-5.65
Log(Vapor Pressure)
-8.81
Melting Point
241.0
pKa Acid
8.07
pKa Basic
7.4
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9502
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9502
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9338
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9338
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9320
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.9320
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9063
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9063
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9032
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9032
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8862
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8862
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8825
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8825
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8796
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8796
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.8750
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.8750
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8748
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8748
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8738
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8738
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8633
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8633
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8598
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8598
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8562
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8562
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8496
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8496
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8476
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8476
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8459
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8459
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8440
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8440
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8423
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8423
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8417
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8417
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8359
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8359
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8349
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8349
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8318
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8318
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8264
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8264
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8243
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8243
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8236
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8236
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8136
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8136
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8122
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8122
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8121
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8121
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8113
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8113
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8101
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8101
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8079
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8079
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8045
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8045
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8037
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8037
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8031
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8031
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8027
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8027
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8016
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8016
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7988
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7988
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7982
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7982
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7904
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7904
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7846
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7846
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7799
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7799
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7780
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7780
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7768
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7768
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7762
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7762
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7749
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7749
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7745
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7745
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7739
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7739
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7717
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7717
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7709
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7709
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7656
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7656
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7626
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7626
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7616
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7616
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7611
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7611
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7594
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7594
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7516
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7516
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7515
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7515
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7486
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7486
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7464
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7464
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7462
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7462
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.7462
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7462
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7393
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7393
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7389
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7389
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7385
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7385
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7383
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7383
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7366
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7366
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7365
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7365
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7351
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7351
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7344
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7344
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7342
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7342
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7335
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7335
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7332
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7332
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7327
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7327
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7311
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7311
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7307
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7307
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7297
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7297
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7295
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7295
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7293
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7293
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7290
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7290
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7285
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7285
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7271
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7271
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7266
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7266
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7247
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7247
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7238
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7238
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7236
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7236
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.7234
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.7234
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7231
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7231
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7226
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7226
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7220
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7220
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7218
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7218
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7211
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7211
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7183
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7183
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7156
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7156
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7154
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7154
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7151
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7151
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7142
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7137
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7137
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7108
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7108
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7102
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 3 0.7102
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7094
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7094
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7081
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7081
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7068
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7068
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7055
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7055
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7047
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7047
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7038
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7038
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7027
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7027
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7026
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7026
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7022
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7022
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7020
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7020
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7004
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7004

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