5,7-dihydroxy-4'-methoxy3′-(3-methylbut-2-enyl)isoflavone - Compound Card

5,7-dihydroxy-4'-methoxy3′-(3-methylbut-2-enyl)isoflavone

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5,7-dihydroxy-4'-methoxy3′-(3-methylbut-2-enyl)isoflavone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1ccc(cc1CC=C(C)C)C1COc2c(C1=O)c(O)cc(c2)O
InChI InChI=1S/C21H22O5/c1-12(2)4-5-14-8-13(6-7-18(14)25-3)16-11-26-19-10-15(22)9-17(23)20(19)21(16)24/h4,6-10,16,22-23H,5,11H2,1-3H3
InChIKey MGSNGDMLFQANLV-UHFFFAOYSA-N
Formula C21H22O5
HBA 5
HBD 2
MW 354.4
Rotatable Bonds 4
TPSA 75.99
LogP 3.97
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 354.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina sacleuxii Leguminosae/Fabaceae Plantae 1899109

Showing of synonyms

  • Yenesew A, Midiwo JO, et al. (1998). Four isoflavones from the stem bark of erythrina sacleuxii. Phytochemistry,1998,49(1),247-249. [View] [PubMed]
Pubchem: 78073079

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OCC(C2=O)c3ccccc3

Level: 1

Mol. Weight: 354.4 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 354.4 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 354.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.63
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.740
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.01

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.330
Plasma Protein Binding
60.57
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.010
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.120
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.860
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.660
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.070
Rat (Acute)
2.020
Rat (Chronic Oral)
2.980
Fathead Minnow
5.030
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
429.790
Hydration Free Energy
-9.720
Log(D) at pH=7.4
3.520
Log(P)
5.0
Log S
-6.68
Log(Vapor Pressure)
-8.22
Melting Point
156.09
pKa Acid
7.45
pKa Basic
6.47
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9538
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9538
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9356
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9356
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9308
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9308
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9287
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9287
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9261
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9261
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9200
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9200
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9127
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9127
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9118
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9118
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.9025
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.9025
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8960
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8960
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8946
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8946
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8937
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8937
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8899
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8899
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8870
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8870
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8798
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8798
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8798
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8798
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8797
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8797
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8750
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8750
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8699
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8699
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8688
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8688
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8642
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8642
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8636
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8636
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8531
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8531
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8512
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8512
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8426
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8426
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8411
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8411
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8379
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8379
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8376
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8376
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8348
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8348
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8347
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8347
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8342
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8342
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8333
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8333
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8296
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8296
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8274
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8274
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8269
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8269
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8249
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8249
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8226
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8226
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.8215
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.8215
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8185
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8185
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8171
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8171
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8151
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8151
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8127
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8127
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8101
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8101
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8098
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8098
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8093
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8093
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8060
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8060
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8058
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.8058
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8012
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8001
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8001
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7995
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7995
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7986
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7986
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7967
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7967
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7941
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7941
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7902
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7902
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7877
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7877
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7830
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7830
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7823
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7823
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7822
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7822
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7821
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7821
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7785
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7785
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7774
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7774
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7772
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7772
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7769
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7769
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7723
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7723
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7722
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7722
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7714
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7714
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7713
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7713
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7703
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7703
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7701
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7701
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7682
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7682
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7681
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7681
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7632
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7632
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7628
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7628
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7599
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7599
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7572
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7572
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7562
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7562
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7534
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7534
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7534
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7534
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7528
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7528
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7523
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7523
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7510
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7510
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7503
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7503
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7496
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7496
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7479
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7479
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7478
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7478
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7467
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7467
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7465
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7465
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7456
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7456
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7451
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7451
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7436
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7436
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7435
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7435
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7416
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7416
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7413
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7413
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7413
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7413
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7413
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7413
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7401
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7401
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7396
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7396
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 4 0.7393
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 4 0.7393
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7377
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7377
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7373
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7373
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7373
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7373
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7365
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7365
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7347
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7347
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7346
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7346
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7344
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7344
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7340
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7340
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7328
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7328
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7324
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7324
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7322
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7322
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7308
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7308
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7302
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7299
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7299
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7295
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7295
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7292
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7292
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7291
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7291
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7285
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7285
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7285
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7285
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7272
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7272
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7267
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7267
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7260
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7260
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7258
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7258
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7252
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7252
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7230
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7230
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7223
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7223
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7222
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7222
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7221
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7221
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7217
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7217
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7215
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7215
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7202
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7202
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7185
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7185
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7173
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7173
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7142
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7142
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7141
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7141
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7136
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7136
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7134
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7134
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7121
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7121
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7115
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7115
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7109
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7109
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7108
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7108
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7086
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7086
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7083
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7083
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7082
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7082
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7078
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7078
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7072
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7072
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7061
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7061
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7057
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7057
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7050
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7050
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7046
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7046
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7030
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7030
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7029
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7029
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7021
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7021
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7020
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7020
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7015
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7015
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7012
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7012
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7008
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7008
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7005
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7005

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