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Sigmoidin E

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavanone

Canonical Smiles	CC(=CCc1cc(cc2c1OC(C)(C)C=C2)[C@@H]1CC(=O)c2c(O1)cc(cc2O)O)C
InChI	InChI=1S/C25H26O5/c1-14(2)5-6-15-9-17(10-16-7-8-25(3,4)30-24(15)16)21-13-20(28)23-19(27)11-18(26)12-22(23)29-21/h5,7-12,21,26-27H,6,13H2,1-4H3/t21-/m0/s1
InChIKey	CKTMJKHXYHXNKU-NRFANRHFSA-N
Formula	C₂₅H₂₆O₅
HBA	5
HBD	2
MW	406.48
Rotatable Bonds	3
TPSA	75.99
LogP	5.5
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	30
Formal Charge	0
Fraction CSP3	0.32
Exact Mass	406.18
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Erythrina abyssinica	Leguminosae/Fabaceae	Plantae	1237573

Showing of synonyms

Yenesew A, Induli M, et al. (2004). Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica.. Phytochemistry,2004,65(22),3029-3032. [View] [PubMed]

Pubchem: 195173

Cas: 116174-67-5

Nmrshiftdb2: 60072182

Chembl: CHEMBL470655

Bindingdb: 50241819

No compound-protein relationship available.

SMILES: c1cccc(c12)OC(CC2=O)c(c3)ccc(c34)OCC=C4

Level: 1

Mol. Weight: 406.48 g/mol

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 406.48 g/mol

SMILES: C1=CCOc(c12)cccc2

Level: 0

Mol. Weight: 406.48 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp): -4.75
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.72
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.17

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.36
Plasma Protein Binding: 80.23
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.07
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.89
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.01
Liver Injury II: Toxic
hERG Blockers: Toxic
Daphnia Maga: 7.16
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -18.98
Rat (Acute): 2.34
Rat (Chronic Oral): 2.71
Fathead Minnow: 5.02
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 472.93
Hydration Free Energy: -6.1
Log(D) at pH=7.4: 4.22
Log(P): 6.21
Log S: -6.99
Log(Vapor Pressure): -8.94
Melting Point: 198.05
pKa Acid: 8.43
pKa Basic: 6.02

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9562
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9562
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8990
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8990
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8976
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8976
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8955
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8955
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8859
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.8859
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8713
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8713
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8588
Xylose isomerase	P24300	XYLA_STRRU	Streptomyces rubiginosus	3	0.8588
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8545
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8545
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8476
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8476
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8463
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.8463
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8444
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8444
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8402
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8402
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8385
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8385
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8192
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8192
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8140
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8140
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8127
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.8127
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8113
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8113
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8102
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.8102
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8051
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8051
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.7990
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	4	0.7990
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7986
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7986
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7958
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7958
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7953
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7953
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7951
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7951
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7904
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7904
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7854
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7854
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7846
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7846
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7844
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7844
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7843
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7843
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7841
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7841
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7817
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7817
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7802
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7802
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7790
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.7790
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7729
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7729
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7697
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7697
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7686
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7686
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7685
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7685
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7601
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7601
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7575
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7575
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7548
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7548
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7547
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7547
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7479
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7479
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7466
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	4	0.7466
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7463
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7463
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7442
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7442
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7408
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7408
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7407
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7407
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	4	0.7402
Single-strand selective monofunctional uracil DNA glycosylase	Q9YGN6	SMUG1_XENLA	Xenopus laevis	4	0.7402
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7386
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7386
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7355
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.7355
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7352
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	3	0.7352
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7346
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7346
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7344
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	3	0.7344
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7340
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7340
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7336
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7336
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7325
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7325
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7306
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7306
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7306
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7306
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7305
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7305
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.7298
Apoptosis regulator Bcl-2	P10415	BCL2_HUMAN	Homo sapiens	3	0.7298
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7289
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7289
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7271
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7271
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7269
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7269
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7269
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7269
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7257
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7257
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7254
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.7254
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7247
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7247
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7245
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7245
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7243
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7243
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7236
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	3	0.7236
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7229
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7229
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7218
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7218
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.7212
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.7212
O-methyltransferase family 2	D5STZ7	D5STZ7_PLAL2	Planctopirus limnophila	4	0.7207
O-methyltransferase family 2	D5STZ7	D5STZ7_PLAL2	Planctopirus limnophila	4	0.7207
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7182
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7182
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7180
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7180
Serine/threonine-protein kinase VRK1	Q99986	VRK1_HUMAN	Homo sapiens	3	0.7169
Serine/threonine-protein kinase VRK1	Q99986	VRK1_HUMAN	Homo sapiens	3	0.7169
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7165
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7165
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7159
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7159
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7156
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7156
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7132
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7132
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7130
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7130
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7123
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7123
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7110
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7110
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7109
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7109
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7108
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7108
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7098
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7098
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7093
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7093
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7089
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7089
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7085
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7085
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7080
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7080
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7071
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7071
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7069
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7069
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	4	0.7043
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	4	0.7043
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7040
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7040
Cytochrome P450 2C19	P33261	CP2CJ_HUMAN	Homo sapiens	3	0.7034
Cytochrome P450 2C19	P33261	CP2CJ_HUMAN	Homo sapiens	3	0.7034
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7030
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7030
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7029
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7029
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7014
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7014
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7001
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7001
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7001
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7001

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