Abyssinoflavone V - Compound Card

Abyssinoflavone V

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Abyssinoflavone V

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles Oc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc2c(c1)C=CC(O2)(C)C
InChI InChI=1S/C20H18O5/c1-20(2)6-5-12-7-11(3-4-16(12)25-20)17-10-15(23)19-14(22)8-13(21)9-18(19)24-17/h3-9,17,21-22H,10H2,1-2H3/t17-/m0/s1
InChIKey WQCFPYAJTXOZMT-KRWDZBQOSA-N
Formula C20H18O5
HBA 5
HBD 2
MW 338.36
Rotatable Bonds 1
TPSA 75.99
LogP 3.99
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 338.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina abyssinica Leguminosae/Fabaceae Plantae 1237573

Showing of synonyms

  • Cui L, Ndinteh DT, et al. (2007). Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.. Journal of Natural Products,2007,70(6),1039-1042. [View] [PubMed]
Pubchem: 16737249
Nmrshiftdb2: 70041291
Bindingdb: 50212394

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c(c3)ccc(c34)OCC=C4

Level: 1

Mol. Weight: 278.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 148.16 g/mol

Structure

SMILES: C1=CCOc(c12)cccc2

Level: 0

Mol. Weight: 132.16 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.56
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.710
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.05

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.260
Plasma Protein Binding
75.69
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.210
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.830
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.070
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
6.070
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
0.900
Rat (Acute)
2.260
Rat (Chronic Oral)
2.660
Fathead Minnow
4.520
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
434.390
Hydration Free Energy
-10.270
Log(D) at pH=7.4
3.570
Log(P)
4.43
Log S
-6.33
Log(Vapor Pressure)
-8.31
Melting Point
204.21
pKa Acid
7.8
pKa Basic
5.47
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9809
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9809
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9170
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9170
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8974
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8974
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8957
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8957
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8941
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8941
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8774
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8774
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8755
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8755
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8713
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8713
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8665
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8665
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8620
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8620
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8565
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8565
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8551
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8551
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8541
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8541
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8533
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8533
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8513
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8513
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8504
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8504
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8477
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8477
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8436
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8436
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8399
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8399
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8340
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8340
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8338
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8338
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8294
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8294
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8293
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8293
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8277
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8277
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8196
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8196
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8155
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8155
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8135
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8135
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8075
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8075
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8035
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8035
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8023
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8023
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7911
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7911
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7871
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7871
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7839
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7839
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7836
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7836
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7813
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7813
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7811
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7811
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7803
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7803
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7790
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7790
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7788
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7788
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7761
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7761
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7759
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7759
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7744
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7744
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7742
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7742
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7695
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7695
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7693
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7693
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7653
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7653
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7651
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7651
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7637
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7637
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7630
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7630
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7629
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7629
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7619
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7619
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7606
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7606
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7603
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7603
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7587
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7587
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7584
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7584
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7583
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7583
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7560
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7560
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7558
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7558
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7556
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7556
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7499
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7499
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.7489
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.7489
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7477
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7477
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7455
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7455
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7454
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7454
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7438
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7438
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7429
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7429
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7393
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7393
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7370
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.7370
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7369
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7369
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7356
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7356
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7333
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7333
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7331
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7331
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7329
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7329
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7318
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7318
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7317
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7317
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7312
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7312
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7307
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7307
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7305
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7305
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7301
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7301
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7297
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7297
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7295
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7295
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7293
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7293
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7293
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7293
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7285
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7285
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7265
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7265
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7263
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7263
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7242
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7242
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7230
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7230
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7216
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7216
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7199
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7199
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7187
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7187
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7173
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7173
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7172
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7172
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7160
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7160
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7153
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7153
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7147
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7147
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7146
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7146
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7146
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7146
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7135
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7135
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7132
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7132
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7124
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7124
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7121
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7121
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7118
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7118
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7117
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7117
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7116
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7116
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7113
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7113
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7103
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7103
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7099
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7099
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7092
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7092
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7089
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7089
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7087
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7087
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7084
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7084
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7081
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7081
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7076
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7076
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7064
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7064
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7032
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7032
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7031
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7031
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7018
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7018
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7012
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7012
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7012
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7012

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