ANPDB

Select a section from the left sidebar

Tachrosin

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavone

Canonical Smiles	COc1cc(OC)c2c(c1C1=COC(C1=O)(C)C)oc(cc2=O)c1ccccc1
InChI	InChI=1S/C23H20O6/c1-23(2)22(25)14(12-28-23)19-17(26-3)11-18(27-4)20-15(24)10-16(29-21(19)20)13-8-6-5-7-9-13/h5-12H,1-4H3
InChIKey	LSNZUXYRWFYNAA-UHFFFAOYSA-N
Formula	C₂₃H₂₀O₆
HBA	6
HBD	0
MW	392.41
Rotatable Bonds	4
TPSA	74.97
LogP	4.2
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	29
Formal Charge	0
Fraction CSP3	0.22
Exact Mass	392.13
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Tephrosia purpurea	Leguminosae/Fabaceae	Plantae	228354

Showing of synonyms

Muiva-Mutisya L, Macharia B, et al. (2014). 6α-Hydroxy-α-toxicarol and (+)-tephrodin with antiplasmodial activities from Tephrosia species.. Phytochemistry Letters,2014,10,179-183. [View] [PubMed]

Pubchem: 1023499

Zinc: ZINC000000689650

Nmrshiftdb2: 70022384

No compound-protein relationship available.

SMILES: O=C1COC=C1c(ccc2)c(c23)oc(cc3=O)-c4ccccc4

Level: 2

Mol. Weight: 392.41 g/mol

SMILES: O=C1COC=C1c(ccc2)c(c23)occc3=O

Level: 1

Mol. Weight: 392.41 g/mol

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 392.41 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 392.41 g/mol

SMILES: O=C1C=COC1

Level: 0

Mol. Weight: 392.41 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 392.41 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp): -4.72
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.690
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.29

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.450
Plasma Protein Binding: 77.32
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 5.880
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.720
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.000
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 7.460
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -19.220
Rat (Acute): 3.080
Rat (Chronic Oral): 2.000
Fathead Minnow: 5.730
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 485.010
Hydration Free Energy: -6.070
Log(D) at pH=7.4: 3.300
Log(P): 3.65
Log S: -5.62
Log(Vapor Pressure): -8.0
Melting Point: 178.3
pKa Acid: 7.49
pKa Basic: 2.85

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9802
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9802
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9744
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9744
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.9629
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.9629
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.9520
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.9520
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.9067
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.9067
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9031
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9031
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8994
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8994
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8944
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8944
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8918
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8918
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8914
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8914
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8820
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8820
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8776
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8776
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8765
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8765
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.8761
cAMP-dependent protein kinase type II-beta regulatory subunit	P12369	KAP3_RAT	Rattus norvegicus	3	0.8761
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8730
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8730
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8711
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8711
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8618
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8618
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8602
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8602
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8591
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8591
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8575
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8575
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8559
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8559
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8552
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8552
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8522
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8522
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8511
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8511
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.8449
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	4	0.8449
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8440
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8440
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8387
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8387
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8376
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8376
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.8361
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.8361
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8348
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8348
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8301
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8301
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8150
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8150
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8148
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8148
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8143
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8143
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8141
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8141
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8128
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8128
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8018
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.8018
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.8015
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.8015
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8010
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8010
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8008
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8008
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8006
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8006
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7969
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7969
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7947
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7947
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7913
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7913
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7913
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7913
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7903
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7903
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7894
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7894
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7862
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7862
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7806
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7806
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7798
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7798
O-methyltransferase family 2	D5STZ7	D5STZ7_PLAL2	Planctopirus limnophila	4	0.7782
O-methyltransferase family 2	D5STZ7	D5STZ7_PLAL2	Planctopirus limnophila	4	0.7782
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7756
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7756
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7739
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7739
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7735
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7735
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7719
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7719
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7708
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7708
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7707
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7707
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7705
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7705
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7638
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.7638
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7632
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7632
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7625
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7625
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7607
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7607
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7584
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7584
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7583
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7583
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7569
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7569
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7542
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7542
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7497
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7497
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7497
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7497
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R_HUMAN	Homo sapiens	3	0.7484
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R_HUMAN	Homo sapiens	3	0.7484
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7472
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7472
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7468
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7468
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7465
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7465
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7465
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7465
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7450
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7450
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7449
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7449
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7427
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7427
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7423
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7423
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7421
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7421
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7416
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7416
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7408
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7408
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7406
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7406
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7403
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7403
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7397
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7397
Mitogen-activated protein kinase 1	P63086	MK01_RAT	Rattus norvegicus	3	0.7395
Mitogen-activated protein kinase 1	P63086	MK01_RAT	Rattus norvegicus	3	0.7395
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7394
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7394
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7370
DNA-directed DNA polymerase	Q38087	DPOL_BPR69	Escherichia phage RB69	3	0.7370
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7357
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7357
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7357
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7357
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7352
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7352
Cytidine deaminase	P19079	CDD_BACSU	Bacillus subtilis	3	0.7351
Cytidine deaminase	P19079	CDD_BACSU	Bacillus subtilis	3	0.7351
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7348
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7348
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7303
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7303
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7301
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7301
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7295
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7295
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7295
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7295
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7285
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7285
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7271
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.7271
Myotonin-protein kinase	Q09013	DMPK_HUMAN	Homo sapiens	3	0.7267
Myotonin-protein kinase	Q09013	DMPK_HUMAN	Homo sapiens	3	0.7267
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7261
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7261
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7253
Pantothenate kinase	P9WPA7	COAA_MYCTU	Mycobacterium tuberculosis	3	0.7253
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7250
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7250
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7249
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7249
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7245
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7245
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7238
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7238
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7238
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7238
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7221
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7221
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	3	0.7206
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	3	0.7206
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7195
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7195
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7174
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7174
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7169
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7169
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7163
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7163
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7155
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7155
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7152
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7152
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7143
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7143
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7139
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7139
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7130
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7130
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7130
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7130
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7117
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7117
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	2	0.7115
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	2	0.7115
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7113
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7113
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7103
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7103
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7060
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7060
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	3	0.7056
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	3	0.7056
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7052
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7052
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7050
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7050
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7041
Lethal factor	P15917	LEF_BACAN	Bacillus anthracis	3	0.7041
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7040
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7040
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7035
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7035
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7019
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7019

Download SDF