3'-(2-hydroxy-3-methylbuten-3-yl)-biochanin A - Compound Card

3'-(2-hydroxy-3-methylbuten-3-yl)-biochanin A

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3'-(2-hydroxy-3-methylbuten-3-yl)-biochanin A

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1ccc(cc1CC(C(=C)C)O)c1coc2c(c1=O)c(O)cc(c2)O
InChI InChI=1S/C21H20O6/c1-11(2)16(23)7-13-6-12(4-5-18(13)26-3)15-10-27-19-9-14(22)8-17(24)20(19)21(15)25/h4-6,8-10,16,22-24H,1,7H2,2-3H3
InChIKey FAGPMPUCWAMJIN-UHFFFAOYSA-N
Formula C21H20O6
HBA 6
HBD 3
MW 368.39
Rotatable Bonds 5
TPSA 100.13
LogP 3.36
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 368.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 368.39 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 368.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 368.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.03
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.840
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.88

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.070
Plasma Protein Binding
74.2
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.240
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.230
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.790
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.110
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-1.120
Rat (Acute)
2.460
Rat (Chronic Oral)
2.760
Fathead Minnow
4.900
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
475.750
Hydration Free Energy
-9.590
Log(D) at pH=7.4
3.110
Log(P)
4.02
Log S
-4.95
Log(Vapor Pressure)
-9.2
Melting Point
182.93
pKa Acid
8.44
pKa Basic
5.43
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9735
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9735
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9521
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9521
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9519
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9519
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9419
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9419
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9408
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9408
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.9357
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.9357
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9209
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9209
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9193
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9193
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9169
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9169
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9118
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9118
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9105
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9105
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9101
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.9101
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9097
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9097
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9090
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9090
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9084
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9084
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9035
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9035
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9010
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9010
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9010
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9010
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8950
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8950
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8950
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8950
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8875
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8875
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8855
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8855
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8849
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8849
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8837
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8837
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8835
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8835
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8833
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8833
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8809
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8809
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8802
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8802
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8789
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8789
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8788
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8788
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8770
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8770
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8744
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8744
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8733
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8733
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8719
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8719
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8712
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8712
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8711
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8711
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8709
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8709
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8691
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8691
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8690
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8690
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8660
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8660
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.8651
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.8651
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8625
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8625
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8617
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8617
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8581
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8581
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8539
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8539
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8515
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8515
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.8485
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.8485
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8430
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8430
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8420
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8420
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8418
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8418
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.8407
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.8407
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8397
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8397
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8382
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8382
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8361
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8361
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8345
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8345
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8343
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8343
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8338
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8338
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8316
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8316
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8309
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8309
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8299
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8299
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.8299
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8299
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8293
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8293
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8289
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8289
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8259
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8259
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8242
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8242
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8221
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8221
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8185
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8185
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8164
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8164
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8162
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8162
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8150
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8150
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8140
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8140
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8135
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8135
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8129
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8129
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8118
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8118
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8094
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8094
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8085
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8085
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8080
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8080
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8079
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8079
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 5 0.8076
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 5 0.8076
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8037
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8037
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8035
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8035
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7973
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7973
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7966
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7966
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7946
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7946
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7916
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7916
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7890
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7890
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7884
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7884
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7874
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7874
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 4 0.7873
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 4 0.7873
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7865
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7865
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7865
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7865
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7855
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7855
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7843
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7843
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7843
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7843
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7836
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7836
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7836
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7836
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7835
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7835
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7834
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7834
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7834
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7834
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7833
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7833
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7827
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.7827
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7813
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7813
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7799
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7799
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7799
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7799
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7771
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7771
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7764
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7764
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7763
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7763
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7758
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7758
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7756
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7756
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7749
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7749
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7729
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7729
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7712
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7712
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7703
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7703
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7702
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7702
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7702
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7702
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7701
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7701
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7686
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7686
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7684
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7684
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7681
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7681
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7653
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7653
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7646
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7646
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7645
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7645
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7638
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7638
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7636
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7636
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7632
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7632
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7632
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7632
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7625
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7625
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7598
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7598
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7593
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7593
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7586
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7586
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 3 0.7579
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 3 0.7579
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7574
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7574
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7569
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7569
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7551
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7551
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7546
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7546
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7538
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7538
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7537
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7537
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7530
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7530
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7529
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7529
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7521
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7521
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7520
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7520
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7519
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7519
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7519
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7519
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7494
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7494
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7491
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7491
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7471
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7471
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7469
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7469
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7467
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7467
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7459
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7459
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7458
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7458
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7458
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7458
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7449
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7449
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7447
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7447
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7442
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7442
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7438
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7438
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7426
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7426
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7418
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7418
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7411
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7411
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7410
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7410
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7401
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7401
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7376
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7376
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7364
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7364
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7356
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7356
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7355
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7355
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 3 0.7352
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 3 0.7352
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7349
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7349
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7348
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7348
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7345
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7345
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7344
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7344
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7343
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7343
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7322
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7322
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7318
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7316
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7316
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7311
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7311
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7311
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7311
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7308
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7308
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7303
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7303
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7300
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7300
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7298
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7298
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7297
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7297
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7295
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7295
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7289
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7289
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7284
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7284
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7283
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7283
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7274
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7274
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7271
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7271
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7270
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7270
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7267
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7267
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7267
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7267
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7261
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7261
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7254
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7254
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7248
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7248
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7244
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7244
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7244
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7244
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7242
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7242
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7237
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7237
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7237
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7237
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7227
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7227
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7220
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7220
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7214
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7214
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7212
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7212
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7209
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7209
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7207
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7207
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7196
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7196
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7190
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7190
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7190
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.7190
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7188
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7188
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7188
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7188
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7185
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7185
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7181
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7181
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7179
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.7179
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7178
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7178
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7173
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7173
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7158
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7158
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7156
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7156
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7155
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7155
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7155
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7155
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7153
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7153
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7152
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7152
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7147
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7147
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7145
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7145
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7145
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7145
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7138
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7131
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7131
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7125
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7125
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7121
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7121
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7120
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7120
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7118
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7118
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7118
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7118
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7118
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7118
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7113
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7113
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7112
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7112
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7109
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7109
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7109
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7109
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7108
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7108
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7103
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7103
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7100
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7100
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7100
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7100
Beta-hexosaminidase Q9KU37 NAGZ_VIBCH Vibrio cholerae serotype O1 3 0.7100
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7100
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7098
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7098
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7095
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7095
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7091
Integrin alpha-IIb P08514 ITA2B_HUMAN Homo sapiens 3 0.7091
Integrin alpha-IIb P08514 ITA2B_HUMAN Homo sapiens 3 0.7091
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7091
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7086
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7086
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7084
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7084
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7080
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7080
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7078
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7078
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7069
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7069
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7067
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7067
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7065
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7065
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7059
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7059
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7058
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7058
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7057
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7057
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7048
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7048
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 4 0.7046
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 4 0.7046
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7043
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7043
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7039
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7039
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7039
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7039
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7036
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 4 0.7036
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7036
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 4 0.7036
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7033
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7033
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7031
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7031
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7029
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7029
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7026
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7026
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7025
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7025
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7025
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7025
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7022
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7022
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7018
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7018
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7017
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7017
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7013
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7013
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7013
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7013
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7007
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7007
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7007
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7007
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7006
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7006
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7006
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7006
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 4 0.7001
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 4 0.7001

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