5,7-dihydroxy-3-[3-hydroxy-4-methoxy-5[(E)-3-methylbuta-1,3-dienyl]phenyl-1- benzopyran-4-one - Compound Card

5,7-dihydroxy-3-[3-hydroxy-4-methoxy-5[(E)-3-methylbuta-1,3-dienyl]phenyl-1- benzopyran-4-one

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5,7-dihydroxy-3-[3-hydroxy-4-methoxy-5[(E)-3-methylbuta-1,3-dienyl]phenyl-1- benzopyran-4-one

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(O)cc(cc1/C=C/C(=C)C)c1coc2c(c1=O)c(O)cc(c2)O
InChI InChI=1S/C21H18O6/c1-11(2)4-5-12-6-13(7-17(24)21(12)26-3)15-10-27-18-9-14(22)8-16(23)19(18)20(15)25/h4-10,22-24H,1H2,2-3H3/b5-4+
InChIKey IGZTUJRKEARSBP-SNAWJCMRSA-N
Formula C21H18O6
HBA 6
HBD 3
MW 366.37
Rotatable Bonds 4
TPSA 100.13
LogP 4.17
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.1
Exact Mass 366.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
Pubchem: 137655968

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.88
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.940
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.35

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.140
Plasma Protein Binding
88.52
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.510
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.590
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.470
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.070
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
0.350
Rat (Acute)
2.230
Rat (Chronic Oral)
3.010
Fathead Minnow
5.110
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
506.040
Hydration Free Energy
-9.750
Log(D) at pH=7.4
3.670
Log(P)
4.78
Log S
-6.23
Log(Vapor Pressure)
-9.02
Melting Point
232.97
pKa Acid
7.11
pKa Basic
5.63
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9413
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9413
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9397
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9397
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9370
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9370
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9189
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9189
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9144
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9144
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9110
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9110
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9088
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9088
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9071
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9071
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8964
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8964
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8933
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8933
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8891
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.8891
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8857
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8857
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8850
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8850
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8838
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8838
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8816
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8816
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8707
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8707
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8700
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8700
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8696
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8696
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8649
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8649
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8635
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8635
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8628
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8628
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8614
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8614
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8586
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8586
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8578
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8578
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8576
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8576
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8567
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8567
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8562
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8562
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8554
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8554
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8533
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8533
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8531
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8531
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8476
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8476
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8463
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8463
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8458
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8458
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8454
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8454
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.8419
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 4 0.8419
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8410
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8410
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8407
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8407
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8392
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8392
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8381
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8381
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8375
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8375
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8351
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8351
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8339
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8339
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 4 0.8338
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 4 0.8338
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8328
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8328
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8242
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.8242
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8210
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8210
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8180
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8180
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8121
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8121
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8080
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8080
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8067
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8067
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8065
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8065
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8000
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8000
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7996
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7996
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7977
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7977
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7969
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7969
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7951
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7951
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7936
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7936
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7924
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7924
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7898
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7898
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7867
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7867
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7836
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7836
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7795
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7795
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7789
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7789
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7771
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7771
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7762
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7762
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7761
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7761
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7749
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7749
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7732
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7732
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7718
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7718
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7696
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7696
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7691
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7691
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7686
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7686
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7646
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7646
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7602
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7602
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7569
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7569
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7569
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7569
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7553
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7553
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7513
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7513
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7496
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7496
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7495
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7495
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7491
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7491
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7482
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7482
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7474
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7474
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7457
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7457
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7448
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7448
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7407
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7407
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7395
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7395
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7395
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7395
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7394
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7394
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7387
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7387
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7378
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7378
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7378
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7378
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7342
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7342
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7341
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7341
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7329
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7329
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7316
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7316
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7309
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7309
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7286
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7286
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7277
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7277
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7265
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7265
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7263
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7263
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7253
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7253
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7252
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7252
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7249
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7249
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7242
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7242
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 4 0.7213
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 4 0.7213
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7201
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7201
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7194
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7194
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7193
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7193
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7191
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7191
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7187
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7187
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7177
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7177
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7157
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7157
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7137
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7137
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7136
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7136
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7130
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7130
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7119
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7119
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7119
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7119
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7117
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7117
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7115
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7115
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7113
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7113
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7098
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7098
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7094
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7094
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7087
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7087
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7083
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7083
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7070
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7070
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7070
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7070
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7061
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7061
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7060
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7060
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7055
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7055
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7046
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7046
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7046
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7046
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7042
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7042
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7030
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7030
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7029
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7029
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7027
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7027
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7018
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7018
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7016
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7016
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7010
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7010
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7009
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7009
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7007
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7007
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7005
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7005
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7004
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7004

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