5,7-dihydroxy-4'-methoxy-3'-(2,3-dihydroxy-3-methylbutyl)isoflavone - Compound Card

5,7-dihydroxy-4'-methoxy-3'-(2,3-dihydroxy-3-methylbutyl)isoflavone

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5,7-dihydroxy-4'-methoxy-3'-(2,3-dihydroxy-3-methylbutyl)isoflavone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1ccc(cc1CC(C(O)(C)C)O)c1coc2c(c1=O)c(O)cc(c2)O
InChI InChI=1S/C21H22O7/c1-21(2,26)18(24)7-12-6-11(4-5-16(12)27-3)14-10-28-17-9-13(22)8-15(23)19(17)20(14)25/h4-6,8-10,18,22-24,26H,7H2,1-3H3
InChIKey KMUJLLLBGMYXNY-UHFFFAOYSA-N
Formula C21H22O7
HBA 7
HBD 4
MW 386.4
Rotatable Bonds 5
TPSA 120.36
LogP 2.55
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 386.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
Pubchem: 91506637

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 386.4 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 386.4 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 386.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.36
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.030
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.52

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.130
Plasma Protein Binding
70.56
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.470
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.360
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.160
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.020
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Toxic
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-2.960
Rat (Acute)
2.500
Rat (Chronic Oral)
2.850
Fathead Minnow
4.690
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
499.140
Hydration Free Energy
-9.840
Log(D) at pH=7.4
2.750
Log(P)
2.91
Log S
-4.92
Log(Vapor Pressure)
-9.03
Melting Point
208.25
pKa Acid
6.77
pKa Basic
6.79
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9521
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9521
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9377
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9377
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9278
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9278
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9207
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9207
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9194
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9194
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9088
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9088
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9066
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9066
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9021
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9021
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9006
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9006
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8986
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8986
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8904
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.8904
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8865
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8865
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8823
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8823
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8803
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8803
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8769
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8769
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8747
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8747
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8714
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8714
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8676
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8676
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8666
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8666
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8657
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8657
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8653
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8653
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8645
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8645
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8632
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8632
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8617
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8617
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8601
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8601
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8571
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8571
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8537
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8537
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8463
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8463
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8435
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8435
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8405
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8405
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8391
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8391
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8390
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8390
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8344
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.8344
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8341
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8341
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8333
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8333
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8331
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8331
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8308
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8308
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8301
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8301
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8297
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8297
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8296
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8296
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8282
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8282
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8252
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8252
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8233
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8233
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8215
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8215
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8191
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8191
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8164
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8164
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8143
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8143
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8126
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.8126
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8083
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8083
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8004
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8004
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7998
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7998
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 5 0.7966
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 5 0.7966
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7951
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7951
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7914
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.7914
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7899
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.7899
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7883
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7883
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7852
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7852
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7851
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7851
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7848
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7848
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7842
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7842
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7833
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7833
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7801
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7801
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7792
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7792
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7782
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7782
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7765
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7765
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7743
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7743
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7743
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7743
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7742
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7742
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7731
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7731
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7730
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7730
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7727
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7727
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7727
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7727
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7712
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7712
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7679
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7679
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7672
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7672
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7662
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7662
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 3 0.7657
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 3 0.7657
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7639
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7639
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7629
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7629
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7622
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7622
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7609
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7609
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7597
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7597
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7591
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7591
Protease O38708 O38708_9HIV1 Human immunodeficiency virus 1 4 0.7575
Protease O38708 O38708_9HIV1 Human immunodeficiency virus 1 4 0.7575
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7540
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7540
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7534
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7534
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7523
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7523
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7510
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7510
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7501
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7501
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7497
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7497
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7495
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7495
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7479
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7474
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7474
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7465
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7465
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7443
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7443
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7441
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7441
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7438
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7438
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7436
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7436
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7428
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7428
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7426
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7426
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7424
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7424
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7421
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7421
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7415
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7415
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7375
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7375
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7363
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7363
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7361
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7361
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7357
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7357
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7353
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7353
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7345
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7345
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7345
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7345
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7330
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7330
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7313
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7313
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7311
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7311
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7310
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7310
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7308
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7308
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7301
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7301
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7300
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7300
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7300
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7300
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7293
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7293
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7289
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7289
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7289
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7289
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7285
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7285
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7281
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7281
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7280
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7280
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7279
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7279
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7265
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7265
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7263
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7263
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7251
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7251
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7246
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7246
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7245
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7245
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7236
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7236
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7225
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7225
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7215
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7215
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7208
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7208
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7194
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7194
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7186
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7186
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7177
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7177
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7174
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7174
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 4 0.7173
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 4 0.7173
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7172
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7172
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7170
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7170
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 3 0.7157
Ribonucleoside-diphosphate reductase large chain 1 P21524 RIR1_YEAST Saccharomyces cerevisiae 3 0.7157
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7156
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7156
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7153
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7153
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7136
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7136
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7133
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7133
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7124
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 3 0.7124
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7103
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7103
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7097
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7097
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7096
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7096
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7087
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7087
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7085
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7085
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7077
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7077
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7067
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7067
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7061
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7061
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7060
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7060
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7053
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7053
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 4 0.7035
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 4 0.7035
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7034
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7034
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7030
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7030
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7023
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7023
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7021
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7021
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7020
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7020
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7015
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7015
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7012
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7012
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7011
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7011
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7003
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7003

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