5'-methoxy-3'-(3-methylbut-2-enyl)biochanin A - Compound Card

5'-methoxy-3'-(3-methylbut-2-enyl)biochanin A

Select a section from the left sidebar

5'-methoxy-3'-(3-methylbut-2-enyl)biochanin A

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(CC=C(C)C)cc(cc1OC)c1coc2c(c1=O)c(O)cc(c2)O
InChI InChI=1S/C22H22O6/c1-12(2)5-6-13-7-14(8-19(26-3)22(13)27-4)16-11-28-18-10-15(23)9-17(24)20(18)21(16)25/h5,7-11,23-24H,6H2,1-4H3
InChIKey RQIDYCZAYSCRKC-UHFFFAOYSA-N
Formula C22H22O6
HBA 6
HBD 2
MW 382.41
Rotatable Bonds 5
TPSA 89.13
LogP 4.4
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.23
Exact Mass 382.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
Pubchem: 44257310
Nmrshiftdb2: 60046250

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 382.41 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 382.41 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 382.41 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.830
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.79

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.310
Plasma Protein Binding
84.84
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.730
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.950
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.250
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.580
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-4.740
Rat (Acute)
2.160
Rat (Chronic Oral)
2.620
Fathead Minnow
5.340
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
479.030
Hydration Free Energy
-7.980
Log(D) at pH=7.4
3.530
Log(P)
5.1
Log S
-6.17
Log(Vapor Pressure)
-8.68
Melting Point
183.06
pKa Acid
8.24
pKa Basic
6.5
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9562
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9562
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9365
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9365
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9331
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9331
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9193
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9193
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9100
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9100
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9088
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9088
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9070
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9070
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9044
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9044
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9043
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9043
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9015
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9015
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8991
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8991
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.8907
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.8907
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8894
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8894
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 4 0.8873
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 4 0.8873
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8854
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8854
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8843
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8843
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8810
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8810
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8797
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8797
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8792
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8792
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8750
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8750
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8728
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8728
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8706
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8706
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8686
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8686
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8676
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8676
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8656
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8656
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8593
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8593
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8588
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8588
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8548
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8548
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8507
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8507
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8500
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8500
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8467
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8467
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8466
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8466
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8440
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8440
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8405
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8405
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8300
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8300
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8277
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8277
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8236
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8236
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8205
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8205
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8178
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8178
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8161
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8161
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8159
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8159
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8155
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.8155
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8142
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8142
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8137
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8137
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8125
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8125
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8106
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8106
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8009
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8009
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8009
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8009
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8002
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8002
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7991
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7991
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7930
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7930
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7918
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7918
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7908
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7908
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7889
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7889
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7863
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7863
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7841
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7841
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7832
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7832
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7803
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7803
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7771
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7771
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7770
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7770
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7734
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7734
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7720
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7720
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7718
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7718
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7645
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7645
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7642
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7642
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7615
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7615
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7609
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7609
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7599
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7599
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7593
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7593
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7590
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7590
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7590
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7590
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7548
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7548
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7543
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7543
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7515
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7515
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7489
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7489
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7489
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7489
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7481
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7481
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7471
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7471
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7462
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7462
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7454
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7454
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7453
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7453
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7445
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7445
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7443
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7443
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7431
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7431
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7405
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7405
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7368
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7368
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7363
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7363
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7360
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7360
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7351
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7351
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7345
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7345
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7340
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7340
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7334
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7334
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7330
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7330
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7324
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7324
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7321
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7321
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7316
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7316
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7311
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7311
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7305
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7305
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7298
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7298
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7290
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7290
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7289
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7289
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7285
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7285
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7284
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7284
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7277
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7277
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7274
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7274
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7266
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7266
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7262
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7262
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7262
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7262
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7250
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7250
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7245
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7245
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7243
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7243
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7240
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7240
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7237
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7237
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7234
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7234
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7232
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7232
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7224
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7224
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7206
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7206
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7204
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7204
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7203
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7203
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7202
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7202
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7185
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7185
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7179
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7179
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7176
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7176
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7175
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7175
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7165
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7165
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7162
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7162
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7151
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7151
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7144
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7144
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7143
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7143
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7140
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7140
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7139
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7139
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7137
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7137
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7137
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7137
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 4 0.7135
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 4 0.7135
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7123
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7123
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7109
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7109
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7101
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7101
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7097
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7097
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7095
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7095
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7083
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7083
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7079
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7079
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7070
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7070
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7062
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7062
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7059
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7059
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7059
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7059
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7057
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7057
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7055
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7055
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7041
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7041
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7033
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7033
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7019
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7019
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7017
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7017
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7014
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7014
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7012
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7012
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 4 0.7007
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 4 0.7007

Download SDF