3'-(3-methylbut-2-enyl)biochanin A - Compound Card

3'-(3-methylbut-2-enyl)biochanin A

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3'-(3-methylbut-2-enyl)biochanin A

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1ccc(cc1CC=C(C)C)c1coc2c(c1=O)c(O)cc(c2)O
InChI InChI=1S/C21H20O5/c1-12(2)4-5-14-8-13(6-7-18(14)25-3)16-11-26-19-10-15(22)9-17(23)20(19)21(16)24/h4,6-11,22-23H,5H2,1-3H3
InChIKey KWZLIQOQDYHGPK-UHFFFAOYSA-N
Formula C21H20O5
HBA 5
HBD 2
MW 352.39
Rotatable Bonds 4
TPSA 79.9
LogP 4.39
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 352.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina sacleuxii Leguminosae/Fabaceae Plantae 1899109
2 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Andayi AW, Yenesew A, et al. (2006). Antiplasmodial flavonoids from Erythrina sacleuxii.. Planta Medica,2006,72(2),187-189. [View] [PubMed]
  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
Pubchem: 15391015
Nmrshiftdb2: 70107071

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 352.39 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 352.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 352.39 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.8
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.760
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.74

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.290
Plasma Protein Binding
84.47
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.490
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.920
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.270
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.110
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
0.670
Rat (Acute)
2.210
Rat (Chronic Oral)
2.710
Fathead Minnow
5.300
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
462.060
Hydration Free Energy
-11.140
Log(D) at pH=7.4
4.200
Log(P)
5.58
Log S
-6.36
Log(Vapor Pressure)
-8.77
Melting Point
184.89
pKa Acid
8.18
pKa Basic
7.08
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9651
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9651
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9533
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9533
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9428
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9428
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9256
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9256
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9194
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9194
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9189
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9189
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9168
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9168
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.9140
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.9140
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9139
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9139
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9089
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9089
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9083
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9083
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9069
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9069
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9068
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9068
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8969
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8969
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8898
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8898
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8891
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8891
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8867
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8867
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8865
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8865
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8836
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8836
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8783
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8783
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8743
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8743
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8739
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8739
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8733
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8733
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8715
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8715
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8705
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8705
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8705
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8705
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8704
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8704
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8671
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8671
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8648
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8648
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8648
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8648
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8603
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.8603
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8597
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8597
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8593
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8593
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8510
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8510
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8504
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8504
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8451
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8451
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8427
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8427
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8364
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8364
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8337
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8337
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8327
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8327
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8300
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8300
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8287
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8287
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8231
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8231
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8203
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8203
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8200
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8200
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8184
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8184
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8172
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8172
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8104
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8104
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8066
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8066
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8039
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8039
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8020
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8020
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8020
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8020
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7984
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7984
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7954
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7954
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 3 0.7897
Phosphodiesterase Q53I60 Q53I60_TRYCR Trypanosoma cruzi 3 0.7897
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7858
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7858
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7832
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7832
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7828
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7828
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7814
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7814
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7812
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7812
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7808
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7808
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7800
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7800
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7799
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7799
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7793
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7793
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7779
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7779
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7770
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7770
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7768
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7768
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7767
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7767
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7762
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7762
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7761
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7761
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7760
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7760
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7754
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7754
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7752
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7752
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7738
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7738
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7737
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7737
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7736
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7736
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7719
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7719
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7711
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7711
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7687
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7687
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7676
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7676
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7670
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7670
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7658
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7658
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7652
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7652
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7645
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7645
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7645
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7645
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 4 0.7629
Serine/threonine-protein kinase B-raf P15056 BRAF_HUMAN Homo sapiens 4 0.7629
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7625
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7625
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7599
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7599
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7592
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7592
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7568
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7568
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7564
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7564
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7560
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7560
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7558
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7558
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7552
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7552
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7548
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7548
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7544
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7544
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7543
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7543
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7533
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7533
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7532
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7532
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7519
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7519
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7499
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7499
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7497
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7497
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7470
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7470
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7467
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7467
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7461
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7461
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7461
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7461
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7458
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7458
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7435
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7435
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7433
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7433
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7431
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7431
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7430
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7430
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7412
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7412
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7386
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7386
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7385
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7385
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7385
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7385
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7371
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7371
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7370
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7370
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7357
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7357
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7353
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7353
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7349
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7349
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7346
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7346
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7341
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7341
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7341
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7341
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7323
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7323
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7323
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7323
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7314
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7314
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7305
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7305
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7305
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7305
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7299
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7299
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7293
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7293
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7287
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7280
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7280
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7265
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7265
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7261
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7261
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7256
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7256
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7255
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7255
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7234
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7234
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7229
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7229
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7228
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7228
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7227
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7227
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7222
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7222
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7220
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7220
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7220
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7220
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7220
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7220
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7219
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7219
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7219
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7219
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7217
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7217
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7214
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7214
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7211
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7211
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7210
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7210
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7204
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7204
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7201
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7201
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7192
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7192
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7184
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7184
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7172
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7172
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7164
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7164
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7160
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7160
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7156
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7156
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7150
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7150
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7145
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7145
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7143
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7143
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7122
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7122
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7117
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7117
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7114
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7114
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7111
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7111
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7109
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7109
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7107
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7107
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7106
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7106
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.7105
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.7105
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7105
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7105
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7103
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7103
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7096
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7096
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7096
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7096
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7076
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7076
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7076
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7076
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7067
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7067
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 4 0.7064
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 4 0.7064
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7060
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7060
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7053
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7053
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7053
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 2 0.7053
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7044
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7044
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7038
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7038
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7036
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7036
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7032
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7032
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7024
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7024
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7023
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7023
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7020
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7020
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7016
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7016
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7005
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7005
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7001
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7001

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