6'-hydroxy-2',3',4,4'-tetra-methoxychalcone - Compound Card

6'-hydroxy-2',3',4,4'-tetra-methoxychalcone

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6'-hydroxy-2',3',4,4'-tetra-methoxychalcone

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1ccc(cc1)/C=C/C(=O)c1c(O)cc(c(c1OC)OC)OC
InChI InChI=1S/C19H20O6/c1-22-13-8-5-12(6-9-13)7-10-14(20)17-15(21)11-16(23-2)18(24-3)19(17)25-4/h5-11,21H,1-4H3/b10-7+
InChIKey FRISOFZUHCOQEC-JXMROGBWSA-N
Formula C19H20O6
HBA 6
HBD 1
MW 344.36
Rotatable Bonds 7
TPSA 74.22
LogP 3.32
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 344.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina schliebenii Leguminosae/Fabaceae Plantae 2590720

Showing of synonyms

  • Nyandoro SS, Munissi JJ, et al. (2017). Flavonoids from Erythrina schliebenii.. Journal of Natural Products,2017,80(2),377-383. [View] [PubMed]
Pubchem: 6253276
Nmrshiftdb2: 60071714
Bindingdb: 50403019

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 208.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.54
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.600
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.64

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.160
Plasma Protein Binding
46.88
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.960
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.560
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.280
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.880
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.600
Rat (Acute)
2.170
Rat (Chronic Oral)
2.860
Fathead Minnow
5.080
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
409.880
Hydration Free Energy
-8.980
Log(D) at pH=7.4
3.690
Log(P)
3.28
Log S
-5.43
Log(Vapor Pressure)
-6.79
Melting Point
123.9
pKa Acid
7.89
pKa Basic
2.04
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9781
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9781
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9576
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9576
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9550
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9550
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9547
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9547
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9367
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9367
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9364
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9364
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9296
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9296
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9282
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9282
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9243
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9243
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9242
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9242
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9148
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9148
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9135
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9135
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9026
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9026
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9018
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9018
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9006
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9006
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9005
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9005
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8975
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8975
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8899
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8899
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8893
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8893
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8881
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8881
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8862
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8862
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8763
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8763
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8760
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8760
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8733
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8733
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8703
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8703
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8644
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8644
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8630
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8630
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8617
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8617
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8611
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8611
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8594
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8594
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8536
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8536
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8509
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8509
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.8508
Succinyl-CoA:acetate CoA-transferase B3EY95 SCACT_ACEAC Acetobacter aceti 3 0.8508
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8499
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8499
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8487
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8487
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8487
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8487
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8425
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8425
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8419
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8419
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8412
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8412
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8393
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8393
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8381
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8381
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8370
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8370
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8321
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8321
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8298
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8298
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8283
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8283
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8279
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8279
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8269
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8269
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8268
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.8268
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8261
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8261
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8236
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8236
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8236
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8236
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8218
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8218
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8190
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8190
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8157
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8157
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8155
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8155
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8137
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8137
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8124
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8124
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8108
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8108
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8101
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8101
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8085
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8085
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8064
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8064
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8028
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.8028
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8017
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8017
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7999
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7999
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7983
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7983
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7958
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7958
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7941
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7941
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7934
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7934
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7880
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7880
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7873
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7873
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7867
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7867
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7853
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7853
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7817
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7817
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7813
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7813
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7795
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7795
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7781
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7781
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7775
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7775
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7770
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7770
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7768
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7768
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7765
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7765
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7753
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7753
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7724
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7724
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7723
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7723
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7706
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7706
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7701
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7701
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7696
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7696
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7693
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7693
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7684
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7684
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7680
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7680
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7665
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7665
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7661
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7661
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7652
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7652
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7644
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7644
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7620
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7620
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7615
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7615
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7610
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7610
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7601
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7601
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7583
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7583
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7570
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7570
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7569
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7569
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7566
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.7566
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7559
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7559
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7555
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7555
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7552
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7552
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7547
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7547
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7539
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7539
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7532
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7532
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7530
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7530
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7524
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7524
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7512
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7512
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7491
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7491
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7490
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7490
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7490
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7490
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7476
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7476
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7466
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7466
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7459
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7459
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7450
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7450
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7448
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7448
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7444
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7444
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7439
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7439
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7434
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7434
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7432
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7432
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7432
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7432
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7410
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7410
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7410
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7410
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7405
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7405
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7402
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7402
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7400
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7400
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7398
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7398
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7398
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7398
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7397
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7397
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7392
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7392
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7391
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7391
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7387
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7387
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7386
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7386
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7386
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7386
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7385
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7385
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7385
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7385
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7385
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7385
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7379
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7379
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7377
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7377
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7373
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7373
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7372
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7372
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7371
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7371
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7362
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7362
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7361
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7361
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7356
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7356
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7354
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7354
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7352
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7352
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7352
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7352
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7350
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7350
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7330
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7330
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7329
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7329
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7323
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7323
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7322
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7322
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7321
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7321
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7307
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7307
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7304
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.7304
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7301
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7301
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7291
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7291
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7288
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7288
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7277
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7277
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7273
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7273
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7272
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7272
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7270
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7270
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7269
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7269
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7265
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7265
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7263
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7263
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7258
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7258
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7258
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7258
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7250
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7250
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7248
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7248
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7243
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7243
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7239
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7239
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7237
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7237
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7232
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7232
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7227
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7227
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7221
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7221
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7218
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7218
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7218
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7218
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7213
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7213
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7209
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7209
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7209
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7209
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7209
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7209
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7207
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7207
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7207
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7207
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7203
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7203
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7201
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7201
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7201
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7201
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7195
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7195
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7188
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7188
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7186
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7186
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7184
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7184
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7182
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7182
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7180
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7180
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7177
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7177
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7176
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7176
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7174
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7174
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7172
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7172
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7165
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7165
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7164
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7164
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7158
Protein RecA Q59560 RECA_MYCS2 Mycolicibacterium smegmatis155) 3 0.7158
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7157
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7157
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7153
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7153
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7146
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7146
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7145
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7145
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7145
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7145
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7134
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7134
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7132
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7132
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7132
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7132
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7131
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7131
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7130
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7130
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7126
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7126
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7120
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7120
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7116
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7116
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7113
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7113
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7108
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7108
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7104
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7104
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7100
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7100
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7099
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7099
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7096
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7096
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7090
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7090
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7089
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7089
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7085
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7085
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7085
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7085
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7076
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7076
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7075
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7075
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7071
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7071
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7068
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7068
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7066
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7066
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7064
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7064
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7064
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7064
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7059
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7059
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7058
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7058
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7047
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7047
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7046
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7046
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7044
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7044
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7042
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7042
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7034
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7034
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7031
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7031
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7029
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7029
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7028
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7028
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7027
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7027
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7022
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7022
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7020
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7020
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7018
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7018
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7015
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7015
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7013
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7013
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7013
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7013
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7008
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7008
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7007
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7007
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7006
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7006
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7000
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7000

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