(2S)-5,7-dimethoxy-8-(3-methylbut-1,3-dienyl)flavanone - Compound Card

(2S)-5,7-dimethoxy-8-(3-methylbut-1,3-dienyl)flavanone

Select a section from the left sidebar

(2S)-5,7-dimethoxy-8-(3-methylbut-1,3-dienyl)flavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(O)c2c(c1/C=C/C(=C)C)O[C@@H](CC2=O)c1ccccc1
InChI InChI=1S/C21H20O4/c1-13(2)9-10-15-19(24-3)12-17(23)20-16(22)11-18(25-21(15)20)14-7-5-4-6-8-14/h4-10,12,18,23H,1,11H2,2-3H3/b10-9+/t18-/m0/s1
InChIKey HIVLZZCXKATCJB-BBVFFXRHSA-N
Formula C21H20O4
HBA 4
HBD 1
MW 336.39
Rotatable Bonds 4
TPSA 55.76
LogP 4.7
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 336.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Tephrosia vogelii Leguminosae/Fabaceae Plantae 1157238

Showing of synonyms

  • Stevenson PC, Kite GC, et al. (2012). Distinct chemotypes of Tephrosia vogelii and implications for their use in pest control and soil enrichment.. Phytochemistry,2012(78),135-146. [View] [PubMed]
Pubchem: 15714484
Chebi: 180258
Nmrshiftdb2: 70002114

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 336.39 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 336.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 336.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.590
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.21

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.320
Plasma Protein Binding
86.45
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.710
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.360
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.550
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.590
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
2.040
Rat (Acute)
2.380
Rat (Chronic Oral)
2.420
Fathead Minnow
4.970
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
414.390
Hydration Free Energy
-9.050
Log(D) at pH=7.4
3.720
Log(P)
5.05
Log S
-6.09
Log(Vapor Pressure)
-7.68
Melting Point
134.17
pKa Acid
8.22
pKa Basic
4.57
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9646
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9646
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9262
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9262
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9198
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9198
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9154
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9154
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9068
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9068
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9058
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9058
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9054
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9054
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8923
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8923
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8910
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8910
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8864
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8864
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8827
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8827
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8785
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8785
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8771
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8771
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8770
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8770
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8727
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8727
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8726
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8726
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8715
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8715
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8613
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8613
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.8567
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.8567
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8444
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8444
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8428
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8428
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8419
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8419
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8391
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.8391
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8374
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8374
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8353
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8353
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8305
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8305
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8214
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8214
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8199
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8199
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8177
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8177
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8172
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8172
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8134
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8134
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8119
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8119
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8098
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8098
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8096
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8096
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8066
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8066
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7994
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7994
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7979
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7979
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7978
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7978
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7978
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7978
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7953
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7953
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7915
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7915
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 3 0.7901
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 3 0.7901
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7883
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7883
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7775
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7775
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7740
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7740
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7734
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7734
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7719
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7719
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7706
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7706
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7671
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7671
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7659
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7659
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7657
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7657
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7643
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7643
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7640
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7640
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7630
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7630
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7624
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7624
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7594
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7594
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7580
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7580
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7548
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7548
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7540
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7540
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7535
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7535
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7491
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7491
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7484
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7484
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7470
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7470
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7470
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7470
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7467
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7467
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7461
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7461
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7445
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7445
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7441
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7441
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7437
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7437
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7423
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7423
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7413
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7413
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7403
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7403
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7389
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7389
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7346
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7346
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7328
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7328
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7326
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7326
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7322
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7319
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7319
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7317
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7317
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7310
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7310
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7307
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7307
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7304
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7304
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7294
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7294
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7292
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7292
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7287
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7287
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7271
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7271
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7265
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7265
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7260
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7260
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7256
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7256
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7245
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7245
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7238
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7238
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7216
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7216
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7216
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7216
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7215
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7215
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7208
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7208
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7205
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7205
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7198
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7198
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7178
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7178
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7161
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7154
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7154
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7129
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7129
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7128
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7128
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7124
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7124
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7121
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7121
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7121
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7121
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7118
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7118
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7113
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7113
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7112
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7112
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7105
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7105
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7100
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7100
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7090
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7090
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7088
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7088
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7087
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7087
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7087
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7087
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7084
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7084
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7075
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7075
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7066
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7066
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7047
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7047
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7028
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7028
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7023
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7023
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7022
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7022
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7021
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7021
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7020
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7020
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7014
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7014
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7011
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7011
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7010
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7010

Download SDF