(2S)-7-hydroxy-5-methoxy-8-prenylflavanone - Compound Card

(2S)-7-hydroxy-5-methoxy-8-prenylflavanone

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(2S)-7-hydroxy-5-methoxy-8-prenylflavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(O)c(c2c1C(=O)C[C@H](O2)c1ccccc1)CC=C(C)C
InChI InChI=1S/C21H22O4/c1-13(2)9-10-15-16(22)11-19(24-3)20-17(23)12-18(25-21(15)20)14-7-5-4-6-8-14/h4-9,11,18,22H,10,12H2,1-3H3/t18-/m0/s1
InChIKey GIJHRPCRRJJXGW-SFHVURJKSA-N
Formula C21H22O4
HBA 4
HBD 1
MW 338.4
Rotatable Bonds 4
TPSA 55.76
LogP 4.62
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 338.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Tephrosia vogelii Leguminosae/Fabaceae Plantae 1157238

Showing of synonyms

  • Stevenson PC, Kite GC, et al. (2012). Distinct chemotypes of Tephrosia vogelii and implications for their use in pest control and soil enrichment.. Phytochemistry,2012(78),135-146. [View] [PubMed]
Pubchem: 101584235

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 338.4 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 338.4 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 338.4 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.69
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.520
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.22

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.150
Plasma Protein Binding
84.96
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.590
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.310
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.110
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
6.620
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.050
Rat (Acute)
1.930
Rat (Chronic Oral)
2.170
Fathead Minnow
4.940
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
417.300
Hydration Free Energy
-7.790
Log(D) at pH=7.4
3.130
Log(P)
4.75
Log S
-5.49
Log(Vapor Pressure)
-7.48
Melting Point
122.49
pKa Acid
8.82
pKa Basic
5.88
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9621
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9621
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9570
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9570
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9403
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9403
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9277
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9277
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9203
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9203
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9082
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9082
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9049
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9049
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9022
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9022
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8985
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8985
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8953
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8953
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8934
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8934
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8857
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8857
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8805
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8805
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8712
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8712
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8674
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8674
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8643
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8643
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8621
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8621
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8613
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8613
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8531
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8531
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8529
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8529
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8517
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8517
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8487
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8487
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8487
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8487
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8444
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8444
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8442
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8442
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8413
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8413
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8410
HTH-type transcriptional regulator QacR P0A0N3 QACR_STAAM Staphylococcus aureus 3 0.8410
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8395
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8395
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8392
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8392
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8367
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8367
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.8344
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.8344
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8312
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8312
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8264
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8264
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8230
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8230
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8218
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8218
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8194
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8194
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8045
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8045
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8023
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8023
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7999
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7999
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7938
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7938
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7895
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7895
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7804
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7804
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7794
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7794
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7782
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7782
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7772
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7772
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7761
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7761
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7733
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7733
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7700
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7700
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7693
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7693
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7681
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7681
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7641
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7641
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7632
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.7632
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7629
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7629
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7629
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7629
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7625
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7625
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7581
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7581
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7580
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7580
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7565
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7565
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7563
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7563
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7549
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7549
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7545
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7545
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7533
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7533
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 6 0.7515
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 6 0.7515
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7506
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7506
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7503
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7503
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7501
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7501
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7501
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7501
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 3 0.7471
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 3 0.7471
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7446
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7446
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7446
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7446
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7432
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7432
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7428
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7428
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7421
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7421
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7415
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7415
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7415
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7415
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7415
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7415
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7403
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7403
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7402
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7402
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7400
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7400
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7379
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7379
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7377
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7377
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7377
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7372
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7372
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7368
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7368
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7367
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7367
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7365
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7365
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7360
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7360
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7356
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7356
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7348
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7348
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7340
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7340
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7339
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7339
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7318
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7318
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7308
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7308
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7302
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7302
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7301
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7301
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7299
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7299
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7298
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7298
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7295
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7295
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7295
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7295
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7291
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7291
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7284
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7284
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7283
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7283
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7279
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7279
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7268
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7268
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7266
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7266
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7261
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7261
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7255
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7255
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7246
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.7246
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7239
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7239
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7236
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7236
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7226
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7226
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7225
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7225
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7223
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7223
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7222
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7222
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7221
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7221
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7202
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7202
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7196
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7196
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7191
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 3 0.7191
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7187
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7187
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7179
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7179
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7178
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7178
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7167
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7167
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7163
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7163
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7155
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7155
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7148
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7148
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7147
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7147
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7131
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7131
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7127
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7127
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7123
Metallo-beta-lactamase type 2 P25910 BLAB_BACFG Bacteroides fragilis 3 0.7123
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7116
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7116
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7114
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7114
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7104
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7104
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7100
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.7100
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7100
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.7100
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7098
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.7098
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7094
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7094
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7085
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7085
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7072
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7072
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7070
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7070
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7068
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7068
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7058
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7058
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7056
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7056
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7056
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7056
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7056
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.7056
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7052
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7052
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7052
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7052
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7046
Heat shock 70 kDa protein 1A P0DMV8 HS71A_HUMAN Homo sapiens 3 0.7046
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7046
Heat shock 70 kDa protein 1A P0DMV8 HS71A_HUMAN Homo sapiens 3 0.7046
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7043
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7043
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7042
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7042
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7033
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7033
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7033
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7033
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7031
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7031
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7029
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7029
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7014
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7014
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7009
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7009
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7005
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7005
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7005
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7005
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7005
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7005
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7003
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7003
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7001
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7001

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