(S)-5,7-dihydroxy-2',4'-dimethoxy-3'-(3''-methylbut-2''-enyl)-isoflavanone - Compound Card

(S)-5,7-dihydroxy-2',4'-dimethoxy-3'-(3''-methylbut-2''-enyl)-isoflavanone

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(S)-5,7-dihydroxy-2',4'-dimethoxy-3'-(3''-methylbut-2''-enyl)-isoflavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavanone
Canonical Smiles COc1ccc(c(c1CC=C(C)C)OC)[C@H]1COc2c(C1=O)c(O)cc(c2)O
InChI InChI=1S/C22H24O6/c1-12(2)5-6-15-18(26-3)8-7-14(22(15)27-4)16-11-28-19-10-13(23)9-17(24)20(19)21(16)25/h5,7-10,16,23-24H,6,11H2,1-4H3/t16-/m1/s1
InChIKey HHTVEHWHGKZBKQ-MRXNPFEDSA-N
Formula C22H24O6
HBA 6
HBD 2
MW 384.43
Rotatable Bonds 5
TPSA 85.22
LogP 3.98
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.32
Exact Mass 384.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Platycelyphium voënse Leguminosae/Fabaceae Plantae 149667

Showing of synonyms

  • Gumula I, Heydenreic M, et al. (2012). Four isoflavanones from the stem bark of Platycelphium voënse.. Phytochemistry Letters,2012,5(1),150–154. [View] [PubMed]
Pubchem: 162866734

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OCC(C2=O)c3ccccc3

Level: 1

Mol. Weight: 384.43 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 384.43 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 384.43 g/mol

Antibacterial
Cytotoxic

Absorption

Caco-2 (logPapp)
-4.63
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.760
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.87

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.250
Plasma Protein Binding
79.61
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.820
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.100
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.680
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
7.070
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-5.440
Rat (Acute)
2.020
Rat (Chronic Oral)
2.900
Fathead Minnow
5.090
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
449.720
Hydration Free Energy
-7.870
Log(D) at pH=7.4
3.340
Log(P)
5.07
Log S
-6.82
Log(Vapor Pressure)
-8.49
Melting Point
160.71
pKa Acid
7.75
pKa Basic
5.4
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9369
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9369
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9317
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9317
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9311
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9311
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9260
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9260
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9256
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9256
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9217
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9217
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9215
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9215
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9083
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9083
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.9075
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.9075
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8940
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8940
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8872
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8872
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8870
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.8870
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8791
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8791
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8740
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8740
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8643
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8643
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8629
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8629
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8570
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8570
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.8552
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.8552
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8445
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8445
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8445
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8445
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8425
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8425
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8412
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8412
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8401
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8401
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8390
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8390
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8305
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8305
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8285
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8285
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8242
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8242
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8229
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8229
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8204
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8204
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8145
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8145
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8117
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8117
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8117
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8117
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8084
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8084
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8075
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8075
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8062
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8062
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7978
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7978
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7957
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7957
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7944
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7944
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7908
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7908
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7905
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7905
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7839
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7839
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7836
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7836
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7835
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7835
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7823
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7823
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7822
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7822
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7802
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7802
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7779
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7779
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7771
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7771
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7768
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7768
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7741
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7741
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7726
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7726
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7709
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7709
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7684
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7684
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7683
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7683
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7682
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7682
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7676
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7676
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7654
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7654
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7596
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7596
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7586
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7586
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7537
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7537
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7526
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7526
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7520
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7520
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7510
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7510
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7503
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7503
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7491
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7491
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7477
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7477
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7472
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.7472
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7436
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7436
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7414
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7414
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7398
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7398
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7390
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7390
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7389
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7389
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7387
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7387
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7380
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7380
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7373
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7373
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7363
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7363
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7349
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7349
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7345
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7345
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7339
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7339
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7335
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7335
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7300
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7300
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7295
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7295
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7281
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7281
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7279
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7279
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7275
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7275
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7264
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7264
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7254
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7254
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 4 0.7251
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 4 0.7251
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7248
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7248
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7235
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7235
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7225
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7225
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7222
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7222
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7198
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7198
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7196
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7196
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7194
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7194
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7192
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7192
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7192
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7192
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7191
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7191
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7183
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7183
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7182
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7182
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7152
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7152
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7150
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7150
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7146
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7146
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7140
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7140
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7133
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7133
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7114
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7114
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7112
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7112
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7100
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7100
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7099
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7099
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7099
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7099
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7096
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7096
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7080
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7080
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7073
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7073
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7070
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7070
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7052
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7052
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7052
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7052
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7043
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7043
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7017
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.7017

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