Formononetin - Compound Card

Formononetin

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Formononetin

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavonoid
Canonical Smiles COc1ccc(cc1)c1coc2c(c1=O)ccc(c2)O
InChI InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
InChIKey HKQYGTCOTHHOMP-UHFFFAOYSA-N
Formula C16H12O4
HBA 4
HBD 1
MW 268.27
Rotatable Bonds 2
TPSA 59.67
LogP 3.17
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 268.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia dura Leguminosae/Fabaceae Plantae 62119
2 Platycelyphium voënse Leguminosae/Fabaceae Plantae 149667
3 Bolusanthus speciosus Leguminosae/Fabaceae Plantae 53838
4 Dalbergia melanoxylon Leguminosae/Fabaceae Plantae 114981
5 Taverniera abyssinica Leguminosae/Fabaceae Plantae 754915
6 Pycnanthus anglonensis Myristicaceae Plantae 224864
7 Staudtia kamerunensis Myristicaceae Plantae 224908
8 Millettia lasiantha Leguminosae/Fabaceae Plantae 185969

Showing of synonyms

  • Mutai P, Heydenreich M, et al. (2013). 3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking studies.. Phytochemistry Letters,2013,30,6(4),671-675. [View] [PubMed]
  • Yenesew A, Midiwo JO, et al. (1997). 6-Methoxycalpogonium Isoflavone A: A New Isoflavone from the Seed Pods of Millettia dura.. Journal of Natural Products,1997,60(8),806–807. [View] [PubMed]
  • Daniel B, Solomon D, et al. (2021). A coumestan and a coumaronochromone from Millettia lasiantha. Biochemical Systematics and Ecology, 2021, 97,104277. [View]
  • Tonga J, Kamdem M, et al. (2022). Antibacterial activity of flavonoids and triterpenoids isolated from the stem bark and sap of Staudtia kamerunensis Warb. (Myristicaceae). Arabian Journal of Chemistry, 2022, 15(10), 104150. [View]
  • Erasto P, Bojase-Moleta G, et al. (2004). Antimicrobial and antioxidant flavonoids from the root wood of Bolusanthus speciosus.. Phytochemistry,2004,65(7),875-880. [View] [PubMed]
  • Gumula I, Heydenreic M, et al. (2012). Four isoflavanones from the stem bark of Platycelphium voënse.. Phytochemistry Letters,2012,5(1),150–154. [View] [PubMed]
  • Duddeck H, Yenesew A, et al. (1987). Isoflavonoids from Taverniera abyssinica.. Bulletin of the Chemical Society of Ethiopia,1987,1(1),36-41. [View] [PubMed]
  • Tsaassi V, Hussain H, et al. (2010). Pycnangloside: A New Cerebroside from Bark of Pycnanthus Angolensis. Natural Product Communications, 2010, 5(11), 1795-1798. [View] [PubMed]
CPRiL: 11959
Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 268.27 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 268.27 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 268.27 g/mol

Antimicrobial
Antimycobacterial
Radical scavenging against dpph

Absorption

Caco-2 (logPapp)
-4.84
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.560
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.37

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.270
Plasma Protein Binding
77.81
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.550
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.660
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.120
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.910
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.170
Rat (Acute)
1.790
Rat (Chronic Oral)
2.060
Fathead Minnow
4.810
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
419.460
Hydration Free Energy
-10.620
Log(D) at pH=7.4
2.810
Log(P)
3.53
Log S
-5.03
Log(Vapor Pressure)
-7.4
Melting Point
239.57
pKa Acid
8.45
pKa Basic
3.37
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9698
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9698
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9680
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9680
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9651
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9651
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9624
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9624
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9551
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9551
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9548
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9548
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9457
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9457
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9446
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9446
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9407
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9407
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9297
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9297
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9294
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9294
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9288
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9288
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9281
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9281
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9275
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9275
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9263
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.9263
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9246
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9246
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9234
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9234
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9205
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9205
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9132
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9132
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9120
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9120
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.9112
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.9112
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9098
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9098
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9085
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9085
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9079
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9079
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9049
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9049
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9005
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9005
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9000
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9000
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8996
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8996
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8979
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8979
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8961
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8961
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8920
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8920
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8909
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8909
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8857
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8857
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8839
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8839
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8808
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8808
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8789
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8789
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8730
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8730
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8709
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8709
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8665
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8665
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8659
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8659
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8618
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8618
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8597
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8597
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8577
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8577
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8576
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8576
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8573
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8573
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8515
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8515
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8481
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8481
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8477
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8477
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8438
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8438
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8423
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8423
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8411
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8411
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8400
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8400
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8370
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8370
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8348
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8348
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8346
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8346
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8302
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8302
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8280
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8280
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8279
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8279
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8262
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8262
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8238
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8238
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.8232
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.8232
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8204
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8204
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8190
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8190
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8157
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8157
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8137
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8137
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.8118
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.8118
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8082
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8082
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8081
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8081
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8072
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8072
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8055
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8055
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8038
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8038
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8013
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8013
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.8004
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.8004
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8002
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.8002
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7995
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7995
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7992
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7992
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7978
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7978
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7969
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7969
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7961
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7961
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.7946
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.7946
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7932
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7932
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7899
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7899
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7887
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7887
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7882
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7882
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7881
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7881
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7863
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7863
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7858
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7858
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7857
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7857
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7844
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7844
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7842
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7842
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7838
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7838
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7809
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7809
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7804
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7804
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7783
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7783
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7779
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7779
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7769
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7769
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7764
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7764
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7762
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7762
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7747
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7747
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7746
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7746
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7733
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7733
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7731
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7731
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7727
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7727
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7723
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7723
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7708
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7708
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7700
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7700
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7694
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7694
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7690
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7690
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7690
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7690
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7684
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7684
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7683
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7683
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7683
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7683
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7671
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7671
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7666
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7666
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7656
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7656
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7646
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7646
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7632
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7632
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7629
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7629
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7628
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7628
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7622
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7622
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7609
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7609
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7605
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7605
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7598
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7598
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7593
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7593
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7593
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7593
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7591
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7591
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7590
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7590
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7589
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7589
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7576
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7576
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 3 0.7547
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 3 0.7547
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7533
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7533
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7533
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7533
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7531
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7531
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7522
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7522
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7512
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7512
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7509
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7509
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7508
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7508
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7506
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7506
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 3 0.7505
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 3 0.7505
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7502
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7502
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7500
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7500
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7497
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7497
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7488
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7488
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7481
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7481
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7478
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7478
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7471
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7471
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7464
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7464
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7458
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7458
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7453
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7453
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7452
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.7452
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7442
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7442
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7441
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7441
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7436
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7436
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7421
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7421
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7418
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7418
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7415
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7415
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7412
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7412
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7408
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7408
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7396
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7396
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7393
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7393
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7393
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7393
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7385
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7385
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7380
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7380
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7378
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7378
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7370
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7370
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7369
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7369
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7369
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7369
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7361
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7361
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7346
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7346
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7333
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7333
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7326
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7326
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7319
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7319
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7317
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7317
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7316
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7316
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7312
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7312
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7309
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7309
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7309
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7309
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7308
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7308
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7302
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7302
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7298
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7298
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7297
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7297
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7295
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7295
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7290
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 2 0.7290
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7289
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7289
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7284
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7284
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7281
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7281
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7277
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7277
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7276
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7276
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7273
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7273
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7270
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7270
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7268
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7268
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7264
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7264
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 2 0.7252
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 2 0.7252
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7247
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 2 0.7247
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7239
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7239
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7234
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7234
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7231
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7231
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7227
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7227
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7226
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7226
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7224
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7224
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7224
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7224
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7221
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7221
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7217
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7217
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7216
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7216
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7215
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7215
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 3 0.7212
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 3 0.7212
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7211
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7211
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7205
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7205
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7205
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7205
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 2 0.7202
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 2 0.7202
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 2 0.7200
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 2 0.7200
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7191
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7191
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7185
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7185
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7179
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7179
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7177
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7177
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7165
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7165
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7163
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7163
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7158
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7158
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7158
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7158
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7155
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7155
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7153
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7153
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7150
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7150
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7150
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7150
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7146
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7146
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 2 0.7145
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 2 0.7145
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7140
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7140
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7139
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7139
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7134
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7134
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7133
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7133
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 4 0.7132
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 4 0.7132
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7131
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7131
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7130
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7130
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7127
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7127
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7127
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7127
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7127
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7127
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 2 0.7127
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7127
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7126
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7126
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7123
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7123
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7123
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7123
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7120
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7120
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7117
2-Hydroxyacid oxidase 1 Q9UJM8 HAOX1_HUMAN Homo sapiens 3 0.7089
2-Hydroxyacid oxidase 1 Q9UJM8 HAOX1_HUMAN Homo sapiens 3 0.7089
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7088
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7088
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7087
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7087
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7086
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7086
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7085
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7085
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7082
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7082
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7082
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7082
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7077
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7077
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7071
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7071
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7069
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7069
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7064
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7064
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7064
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7064
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7063
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7063
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7061
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7061
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7056
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7056
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7054
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7054
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7053
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7053
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7052
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7052
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7049
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7049
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7049
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7049
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7047
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7047
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7046
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7046
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7043
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7043
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7043
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7043
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7034
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7034
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7033
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7033
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7025
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7025
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7023
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7023
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7022
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7022
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7021
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7021
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7019
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7019
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7018
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7018
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7016
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7016
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.7016
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7016
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7013
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7013
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7012
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7012
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7010
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7010
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7009
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7009
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7007
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7007

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