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Corylin

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavone

Canonical Smiles	Oc1ccc2c(c1)occ(c2=O)c1ccc2c(c1)C=CC(O2)(C)C
InChI	InChI=1S/C20H16O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)16-11-23-18-10-14(21)4-5-15(18)19(16)22/h3-11,21H,1-2H3
InChIKey	PWAACAMQKVIVPZ-UHFFFAOYSA-N
Formula	C₂₀H₁₆O₄
HBA	4
HBD	1
MW	320.34
Rotatable Bonds	1
TPSA	59.67
LogP	4.35
Number Rings	4
Number Aromatic Rings	3
Heavy Atom Count	24
Formal Charge	0
Fraction CSP3	0.15
Exact Mass	320.1
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Erythrina sacleuxii	Leguminosae/Fabaceae	Plantae	1899109

Showing of synonyms

Andayi AW, Yenesew A, et al. (2006). Antiplasmodial flavonoids from Erythrina sacleuxii.. Planta Medica,2006,72(2),187-189. [View] [PubMed]

Pubchem: 5316097

Cas: 53947-92-5

Gnps: CCMSLIB00006420558

Zinc: ZINC000013408703

Nmrshiftdb2: 60025755

Chembl: CHEMBL1271888

Bindingdb: 50349976

CPRiL: 71251

SMILES: c1cccc(c12)occ(c2=O)-c(c3)ccc(c34)OCC=C4

Level: 1

Mol. Weight: 320.34 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 320.34 g/mol

SMILES: C1=CCOc(c12)cccc2

Level: 0

Mol. Weight: 320.34 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp): -4.87
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.630
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.09

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.290
Plasma Protein Binding: 73.98
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.590
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 1.910
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.100
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.540
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Toxic
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.970
Rat (Acute): 2.890
Rat (Chronic Oral): 1.760
Fathead Minnow: 4.950
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 465.070
Hydration Free Energy: -10.500
Log(D) at pH=7.4: 3.750
Log(P): 4.69
Log S: -5.57
Log(Vapor Pressure): -8.92
Melting Point: 246.37
pKa Acid: 8.41
pKa Basic: 5.69

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9554
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9554
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9541
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9541
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9473
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9473
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9293
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9293
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9273
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9273
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9222
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.9222
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.9215
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.9215
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9209
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.9209
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9149
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9149
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9145
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9145
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9090
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9090
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9039
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9039
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8998
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8998
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8947
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8947
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.8806
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.8806
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8794
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8794
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8782
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8782
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8716
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8716
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8704
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8704
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8561
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8561
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8525
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8525
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8522
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8522
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.8506
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.8506
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8483
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.8483
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8466
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.8466
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8402
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8402
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8398
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8398
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8381
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8381
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8299
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8299
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8214
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8214
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8145
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8145
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8055
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8055
Beta-elicitin cinnamomin	P15569	ELIB_PHYCI	Phytophthora cinnamomi	3	0.8021
Beta-elicitin cinnamomin	P15569	ELIB_PHYCI	Phytophthora cinnamomi	3	0.8021
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7949
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7949
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7875
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7875
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7862
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7862
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7861
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7861
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7842
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7842
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7780
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7780
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	4	0.7778
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	4	0.7778
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7776
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7776
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7776
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7776
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7764
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7764
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7711
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7711
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7682
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7682
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7674
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7674
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7635
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7635
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7582
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7582
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7568
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7568
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7557
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7557
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7534
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7534
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7531
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7531
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7525
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7525
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	4	0.7494
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	4	0.7494
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7486
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7486
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7461
Transthyretin	Q9PTT3	Q9PTT3_SPAAU	Sparus aurata	3	0.7461
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7444
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7444
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7435
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.7435
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7431
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7431
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7415
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7415
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7415
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7415
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7409
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7409
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.7383
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.7383
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7370
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7370
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7359
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7359
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7332
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7332
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7305
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7305
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7291
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7291
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7277
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7277
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7276
Putative N-acetyl glucosaminyl transferase	Q6U8B0	Q6U8B0_RAOTE	Raoultella terrigena	3	0.7276
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7264
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7264
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7228
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7228
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7225
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7225
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7172
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7172
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7162
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7162
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7159
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7159
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7159
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7159
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7154
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7154
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7135
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7135
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7134
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7134
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7134
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7134
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7124
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7124
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7098
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7098
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7088
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7088
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7088
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7088
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7086
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7086
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q9R1E6	ENPP2_MOUSE	Mus musculus	3	0.7072
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q9R1E6	ENPP2_MOUSE	Mus musculus	3	0.7072
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7070
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7070
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7067
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7067
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7061
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7061
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7053
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7053
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7041
Cartilage oligomeric matrix protein	Q9R0G6	COMP_MOUSE	Mus musculus	3	0.7041
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7041
Cartilage oligomeric matrix protein	Q9R0G6	COMP_MOUSE	Mus musculus	3	0.7041
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7036
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7036
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7031
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7031
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	4	0.7030
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	4	0.7030
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7012
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.7012
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7009
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7009
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7004
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7004

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