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3'-prenylbiochanin

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavone

Canonical Smiles	COc1c(O)cc(cc1CC=C(C)C)c1coc2c(c1=O)c(OC)cc(c2)O
InChI	InChI=1S/C22H22O6/c1-12(2)5-6-13-7-14(8-17(24)22(13)27-4)16-11-28-19-10-15(23)9-18(26-3)20(19)21(16)25/h5,7-11,23-24H,6H2,1-4H3
InChIKey	UWXYUEZCGLSJLG-UHFFFAOYSA-N
Formula	C₂₂H₂₂O₆
HBA	6
HBD	2
MW	382.41
Rotatable Bonds	5
TPSA	89.13
LogP	4.4
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	28
Formal Charge	0
Fraction CSP3	0.23
Exact Mass	382.14
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Erythrina sacleuxii	Leguminosae/Fabaceae	Plantae	1899109

Showing of synonyms

Andayi AW, Yenesew A, et al. (2006). Antiplasmodial flavonoids from Erythrina sacleuxii.. Planta Medica,2006,72(2),187-189. [View] [PubMed]

Pubchem: 5487391

Cas: 132587-59-8

Comptox: DTXSID00157649

No compound-protein relationship available.

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 382.41 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 382.41 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 382.41 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp): -4.76
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.760
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.29

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.380
Plasma Protein Binding: 81.16
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 7.520
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.710
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.970
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.800
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -4.850
Rat (Acute): 2.190
Rat (Chronic Oral): 2.750
Fathead Minnow: 5.420
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 474.070
Hydration Free Energy: -7.770
Log(D) at pH=7.4: 3.330
Log(P): 4.57
Log S: -6.28
Log(Vapor Pressure): -8.48
Melting Point: 197.48
pKa Acid: 9.02
pKa Basic: 5.8

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9561
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9561
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.9434
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.9434
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9331
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9331
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9231
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9231
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.9163
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.9163
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9077
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9077
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9030
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9030
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8939
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8939
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8928
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8928
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.8910
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.8910
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8898
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8898
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.8878
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.8878
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8865
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8865
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8864
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8864
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8855
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8855
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8854
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8854
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8824
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8824
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8803
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8803
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8800
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8800
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8774
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8774
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8769
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8769
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8742
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8742
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8711
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8711
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8685
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8685
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8658
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8658
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8643
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8643
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8629
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8629
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8617
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8617
Phosphodiesterase	Q53I60	Q53I60_TRYCR	Trypanosoma cruzi	4	0.8598
Phosphodiesterase	Q53I60	Q53I60_TRYCR	Trypanosoma cruzi	4	0.8598
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8574
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8574
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8488
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8488
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8452
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8452
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.8439
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.8439
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8413
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8413
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8393
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8393
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8365
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8365
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	4	0.8362
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	4	0.8362
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8288
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8288
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8272
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8272
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.8258
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.8258
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8195
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8195
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8168
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8168
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8141
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8141
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.8130
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.8130
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8116
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8116
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8087
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8087
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8072
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8072
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8045
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8045
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7976
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7976
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7974
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7974
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7972
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7972
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7969
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7969
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7961
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7961
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7958
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7958
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7943
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.7943
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7929
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7929
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7917
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7917
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7902
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7902
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7900
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7900
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7892
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7892
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7881
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7881
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7876
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7876
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7844
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7844
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7840
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7840
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7796
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7796
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7789
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7789
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7773
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7773
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7770
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7770
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	4	0.7724
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	4	0.7724
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7613
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7613
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7596
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7596
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7569
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7569
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7567
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7567
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7556
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7556
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7554
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7554
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7516
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7516
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7509
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7509
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7480
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.7480
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7471
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7471
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7467
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7467
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7464
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7464
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7462
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7462
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7453
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7453
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7445
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7445
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7429
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7429
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7422
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7422
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7420
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7420
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7413
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7413
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7405
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7405
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7396
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.7396
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	3	0.7392
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7392
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7392
Sepiapterin reductase	Q64105	SPRE_MOUSE	Mus musculus	3	0.7392
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7383
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7383
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7378
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7378
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7377
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7377
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7376
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7376
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7372
Aminoglycoside N(3)-acetyltransferase	A0A3P1UCA6	Q81P86_BACAN	Bacillus anthracis	3	0.7372
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7343
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.7343
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7336
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7336
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7328
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7328
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	4	0.7322
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	4	0.7322
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7308
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7308
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7307
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7307
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7307
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7307
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7301
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7301
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7294
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7294
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7290
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7290
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7286
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7286
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	4	0.7276
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	4	0.7276
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7267
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7267
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7264
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7264
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7258
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7258
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7257
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7257
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7249
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7249
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7235
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7235
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7234
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7234
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7231
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7231
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7230
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7230
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7228
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7228
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7221
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7221
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7191
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7191
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7190
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7190
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7188
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7188
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7178
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7178
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7177
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7177
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7173
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7173
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7155
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7155
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7151
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7151
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7149
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7149
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.7145
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.7145
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7140
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7140
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7122
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7122
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7115
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7115
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7108
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7108
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7104
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7104
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7104
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7104
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7100
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7100
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7092
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7092
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7088
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7088
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7067
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7067
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7064
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7064
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7042
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7042
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7042
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7042
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7026
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7026
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7025
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7025
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7012
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7012
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7012
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7012
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7009
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7009
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7002
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7002

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