5'-formylpratensein - Compound Card

5'-formylpratensein

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5'-formylpratensein

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles O=Cc1cc(ccc1OC)c1coc2c(c1=O)c(O)cc(c2)O
InChI InChI=1S/C17H12O6/c1-22-14-3-2-9(4-10(14)7-18)12-8-23-15-6-11(19)5-13(20)16(15)17(12)21/h2-8,19-20H,1H3
InChIKey AYDFNNGMLSGMFJ-UHFFFAOYSA-N
Formula C17H12O6
HBA 6
HBD 2
MW 312.28
Rotatable Bonds 3
TPSA 96.97
LogP 2.69
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 312.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina sacleuxii Leguminosae/Fabaceae Plantae 1899109

Showing of synonyms

  • Andayi AW, Yenesew A, et al. (2006). Antiplasmodial flavonoids from Erythrina sacleuxii.. Planta Medica,2006,72(2),187-189. [View] [PubMed]
Pubchem: 76313109

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 312.28 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 312.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 312.28 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.86
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.79
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.72

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.83
Plasma Protein Binding
68.8
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.15
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.71
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.23
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.44
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Toxic
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
3.41
Rat (Acute)
2.16
Rat (Chronic Oral)
2.41
Fathead Minnow
4.7
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
461.41
Hydration Free Energy
-12.87
Log(D) at pH=7.4
2.36
Log(P)
3.37
Log S
-5.19
Log(Vapor Pressure)
-8.72
Melting Point
236.38
pKa Acid
7.24
pKa Basic
3.03
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9605
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9605
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9526
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9526
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9450
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9450
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9326
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9326
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9318
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9318
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9299
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9299
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9293
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9293
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9190
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9190
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9187
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9187
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9140
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.9140
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9131
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 4 0.9131
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9061
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9061
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9048
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9048
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9018
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9018
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9016
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.9016
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8971
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8971
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8964
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8964
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8928
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8928
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8916
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8916
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8905
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8905
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8788
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8788
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8760
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8760
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8737
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8737
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8720
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8720
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8714
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8714
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8695
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8695
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8683
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8683
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8673
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8673
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8669
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8669
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8644
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8644
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8642
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8642
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8579
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8579
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8578
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.8578
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8576
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8576
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8565
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8565
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8557
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8557
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8546
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8546
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8531
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8531
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8504
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8504
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8469
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8469
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8421
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8421
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8397
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8397
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8361
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8361
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8330
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8330
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8320
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8320
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8287
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.8287
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8283
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8283
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8280
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8280
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8240
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8240
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8237
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8237
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8211
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8211
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8183
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8183
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8173
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8173
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8115
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8115
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8110
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8110
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8026
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8026
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8012
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8012
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7964
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7964
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7930
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7930
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7886
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7886
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7845
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7845
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7845
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7845
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7844
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7844
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7816
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7816
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7802
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7802
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7791
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7791
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7781
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7781
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7781
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7781
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7767
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7767
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7757
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7757
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7744
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7744
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7731
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7731
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7712
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7712
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7712
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7712
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7695
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7695
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7664
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7664
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7659
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7659
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7653
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.7653
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7647
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7647
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7637
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7637
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7635
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7635
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7617
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7617
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7616
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7616
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7614
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7614
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7613
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7613
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7609
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7609
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7601
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7601
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7584
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7584
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7561
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7561
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7561
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7561
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7559
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7559
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7545
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7545
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7541
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7541
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7541
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7541
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7517
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7517
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7506
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7506
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7505
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7505
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7493
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7493
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7475
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7475
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7470
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7470
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7463
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7463
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7462
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7462
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7458
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7458
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7434
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7434
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7432
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7432
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7427
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7427
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7426
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7426
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7425
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7425
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7415
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7415
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7412
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7412
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7409
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7409
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7402
Ephrin type-A receptor 4 Q03137 EPHA4_MOUSE Mus musculus 4 0.7402
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7398
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7398
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7398
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7398
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7397
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7397
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7390
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7390
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7378
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7378
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7353
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7353
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7349
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7349
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7343
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7343
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7338
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7338
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7316
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7316
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7314
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7314
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7314
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7314
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7309
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7309
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7309
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7309
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7296
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7296
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7286
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7286
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7281
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7281
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7277
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7277
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7276
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7276
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7271
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 4 0.7271
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7266
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7266
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7266
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7266
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7262
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7262
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7257
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7257
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7254
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7254
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7250
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7250
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7235
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7235
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7234
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7234
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7233
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7233
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7212
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7212
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7210
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7210
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7208
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7208
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7207
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7207
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7195
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7195
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7185
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7185
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7164
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7164
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7163
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 4 0.7163
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7154
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 4 0.7154
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7148
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7148
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7140
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7140
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7129
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7129
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7125
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7125
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7116
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7116
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7111
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7111
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7108
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7108
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7107
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7107
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7098
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7098
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7086
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7086
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7085
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7085
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7074
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7074
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7073
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7073
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7072
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7072
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7071
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7071
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7066
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7066
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7062
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7062
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7056
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7056
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7052
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7052
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7046
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7046
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7037
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7037
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7033
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7033
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7027
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7027
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7026
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7026
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7025
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7025
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7022
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7022
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7021
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7021
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7012
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7012
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7005
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7005
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7001
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 4 0.7001

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