7,2'-dimethoxy-4',5'-methylenedioxyisoflavone - Compound Card

7,2'-dimethoxy-4',5'-methylenedioxyisoflavone

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7,2'-dimethoxy-4',5'-methylenedioxyisoflavone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Isoflavone
Canonical Smiles COc1cc2OCOc2cc1c1coc2c(c1=O)ccc(c2)OC
InChI InChI=1S/C18H14O6/c1-20-10-3-4-11-15(5-10)22-8-13(18(11)19)12-6-16-17(24-9-23-16)7-14(12)21-2/h3-8H,9H2,1-2H3
InChIKey MSPWKPQQHHCXLR-UHFFFAOYSA-N
Formula C18H14O6
HBA 6
HBD 0
MW 326.3
Rotatable Bonds 3
TPSA 67.13
LogP 3.21
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 326.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia dura Leguminosae/Fabaceae Plantae 62119
2 Millettia dura Leguminosae/Fabaceae Plantae 62119
3 Millettia dura Leguminosae/Fabaceae Plantae 62119
4 Millettia dura Leguminosae/Fabaceae Plantae 62119
5 Millettia dura Leguminosae/Fabaceae Plantae 62119
6 Millettia dura Leguminosae/Fabaceae Plantae 62119

Showing of synonyms

  • Derese S, Barasa L, et al. (2014). 4'-Prenyloxyderrone from the stem bark of Millettia oblata ssp. teitensis and the antiplasmodial activities of isoflavones from some Millettia species.. Phytochemistry Letters,2014,31(8),69-72. [View] [PubMed]
  • Buyinza D, Yang LJ, et al. (2021). Cytotoxicity of isoflavones from Millettia dura. Natural product research, 2021, 35(16), 2744–2747. [View]
  • Buyinza D, Chalo DM, et al. (2020). Flavonoids and Isoflavonoids of Millettia dura and Millettia ferruginea: Phytochemical review and chemotaxonomic values. Biochemical Systematics and Ecology, 2020, 91, 104053. [View]
  • Marco M, Deyou T, et al. (2016). Pterocarpans and Isoflavones from the Root Bark of Millettia micans and of Millettia dura. Advances in Drug Discovery and Development,2016,1,1-8. [View] [PubMed]
  • Marco M, Deyou T, et al. (2017). Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura.. Phytochemistry Letters,2017,21,216-220.. [View] [PubMed]
  • Marco M, Deyou T, et al. (2016). Pterocarpans and isoflavones from the root bark of Millettia micans and of Millettia dura.. Advances in Drug Discovery and Development, 2016, 1-8. [View] [PubMed]
Pubchem: 343083
Chebi: 93558
Nmrshiftdb2: 70014696

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)ccc(c2)-c(c3=O)coc(c34)cccc4

Level: 1

Mol. Weight: 326.3 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 326.3 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 326.3 g/mol

Anti-plasmodial
Cytotoxic

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.390
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.45

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.500
Plasma Protein Binding
84.55
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.670
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.830
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.960
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.440
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.680
Rat (Acute)
2.330
Rat (Chronic Oral)
1.540
Fathead Minnow
5.380
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
447.680
Hydration Free Energy
-8.410
Log(D) at pH=7.4
3.170
Log(P)
3.7
Log S
-4.89
Log(Vapor Pressure)
-7.61
Melting Point
164.05
pKa Acid
8.92
pKa Basic
0.4
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9727
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9727
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9698
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9698
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9623
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9623
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9618
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9618
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9561
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9561
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9479
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9438
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9438
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9432
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9432
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9418
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9418
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9383
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9383
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9379
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9379
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9375
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9375
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9373
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9373
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9338
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9338
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9334
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9334
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9328
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9328
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9278
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9278
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9266
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9266
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9213
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9213
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9189
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.9189
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9106
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.9106
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9099
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9099
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9089
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9089
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9057
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9057
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9023
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.9023
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9014
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9014
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8985
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8985
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8966
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8966
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8829
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8829
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8803
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8803
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8792
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.8792
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8740
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8740
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8736
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8736
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8727
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8727
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8707
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8707
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8704
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.8704
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8702
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8702
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8676
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.8676
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8671
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8671
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8665
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8665
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8656
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8656
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8648
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8648
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8620
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8620
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8614
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8614
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8604
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8604
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8578
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8578
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8551
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8551
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8550
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8550
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8542
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8542
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8523
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8523
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8489
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8489
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8473
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8473
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8459
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8459
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8440
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8440
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8422
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8422
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8412
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8412
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8349
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8349
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8312
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8312
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8311
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8311
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8306
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8306
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8256
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8256
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8241
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8241
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8230
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8230
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8194
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8194
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.8182
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.8182
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8172
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.8172
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8165
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8165
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8156
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8156
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8145
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8145
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8138
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8138
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8105
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8105
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8086
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8086
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8082
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8082
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.8064
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.8064
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8061
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8061
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8052
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8052
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8045
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8045
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8037
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8037
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8024
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8024
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7997
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7997
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7977
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7977
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7971
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7971
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7918
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7918
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7917
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7917
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7911
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7911
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7903
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7903
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7892
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7892
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7876
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7876
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7874
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7874
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7850
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7850
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7847
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7847
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7842
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7842
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7829
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7829
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7813
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7813
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7791
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7791
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7790
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7790
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7787
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7787
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7786
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7786
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7775
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7775
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7767
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7767
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7759
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7759
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 4 0.7734
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 4 0.7734
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7721
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7721
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7711
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7711
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7711
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7711
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7667
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7667
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7653
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7653
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7648
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7648
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7625
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7625
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7619
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7619
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7609
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7609
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7591
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7591
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7586
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7586
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 3 0.7581
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 3 0.7581
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7580
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7580
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7579
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7579
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7578
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7578
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7560
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7560
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7554
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7554
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7544
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7544
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7540
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7540
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7539
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7539
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7538
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7538
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7531
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7531
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7531
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7531
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7526
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7526
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7526
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7526
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7514
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7514
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7504
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7504
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7501
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7501
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.7498
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 4 0.7498
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7497
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7497
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7494
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7494
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7483
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7483
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7481
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7481
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7472
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7472
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7471
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7471
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7443
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7443
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7432
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7432
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7431
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7431
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7421
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7421
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7420
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 3 0.7420
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7413
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7413
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7413
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7413
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7412
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7412
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7411
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7411
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7408
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7408
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7401
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7401
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7398
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7398
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7397
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7397
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7395
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7395
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7388
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7388
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7387
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7387
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7376
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7376
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7373
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7373
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7356
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7356
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 3 0.7346
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 3 0.7346
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7345
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7345
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7345
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7345
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7342
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7342
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7341
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7341
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7332
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7332
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7332
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7332
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7324
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7324
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7319
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7319
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7316
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7316
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7311
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7311
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7310
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7310
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7302
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7298
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7298
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7293
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7293
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7292
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7292
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7291
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7291
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7289
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7289
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7283
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7283
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7282
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7282
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7281
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7281
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7279
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7279
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7277
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7277
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7272
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7272
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7270
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7270
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7269
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7269
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7249
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7249
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7245
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7245
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7233
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7229
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7229
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7226
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7226
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7224
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7224
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7220
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7220
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7208
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7208
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7205
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7205
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7202
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7202
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7202
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7202
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7190
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 3 0.7190
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7188
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7188
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7178
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7178
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7176
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7176
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7173
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7173
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7173
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7173
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7172
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7172
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7171
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7171
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7170
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7170
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7165
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7165
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7163
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7163
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7161
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7161
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7156
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7156
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7152
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7152
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7149
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7149
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7146
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7146
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7139
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7139
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7136
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7136
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7127
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7127
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7126
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7126
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7121
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7121
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7119
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7119
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7116
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7116
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7110
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7110
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7108
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7108
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7108
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7108
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7106
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7106
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7096
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7096
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7093
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7093
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7092
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 3 0.7092
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7091
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7091
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7090
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7090
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7090
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7090
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7088
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7088
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7083
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 3 0.7083
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7083
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7083
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 3 0.7080
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 3 0.7080
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7075
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7075
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7075
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7075
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7073
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7064
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7064
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7063
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7063
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7063
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7063
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7058
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7058
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7054
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7054
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7053
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7053
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7052
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7052
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7046
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7046
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7043
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7043
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7036
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7036
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7032
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7032
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7032
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7032
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7027
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7027
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7024
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7024
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7010
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7010
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7009
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7009
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7008
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7008
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7005
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7005
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7005
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7005
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7003
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7003

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