5,7,4'-trihydroxy-6-[1-hydroxy-2-methylbuten-2-yl]isoflavone - Compound Card

5,7,4'-trihydroxy-6-[1-hydroxy-2-methylbuten-2-yl]isoflavone

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5,7,4'-trihydroxy-6-[1-hydroxy-2-methylbuten-2-yl]isoflavone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles OC/C(=C/Cc1c(O)cc2c(c1O)c(=O)c(co2)c1ccc(cc1)O)/C
InChI InChI=1S/C20H18O6/c1-11(9-21)2-7-14-16(23)8-17-18(19(14)24)20(25)15(10-26-17)12-3-5-13(22)6-4-12/h2-6,8,10,21-24H,7,9H2,1H3/b11-2+
InChIKey AROTXIUFXQZGLT-BIIKFXOESA-N
Formula C20H18O6
HBA 6
HBD 4
MW 354.36
Rotatable Bonds 4
TPSA 111.13
LogP 3.06
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.15
Exact Mass 354.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Bolusanthus speciosus Leguminosae/Fabaceae Plantae 53838

Showing of synonyms

  • Erasto P, Bojase-Moleta G, et al. (2004). Antimicrobial and antioxidant flavonoids from the root wood of Bolusanthus speciosus.. Phytochemistry,2004,65(7),875-880. [View] [PubMed]
Pubchem: 5378945
Nmrshiftdb2: 70014241

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 354.36 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 354.36 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 354.36 g/mol

Antimicrobial
Radical scavenging against dpph

Absorption

Caco-2 (logPapp)
-5.25
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.99
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.36

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.88
Plasma Protein Binding
77.77
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.48
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.17
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.39
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.72
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Toxic
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
0.5
Rat (Acute)
2.36
Rat (Chronic Oral)
2.95
Fathead Minnow
5.09
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
505.67
Hydration Free Energy
-12.62
Log(D) at pH=7.4
2.66
Log(P)
3.5
Log S
-4.78
Log(Vapor Pressure)
-9.6
Melting Point
228.72
pKa Acid
5.9
pKa Basic
6.45
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9701
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9701
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9496
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.9496
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.9237
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.9237
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.9095
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.9095
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9091
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9091
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9002
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9002
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8930
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.8930
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8894
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8894
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8877
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.8877
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8847
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8847
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8813
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8813
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8774
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8774
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8735
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8735
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8709
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8709
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8699
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8699
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8676
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8676
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 3 0.8660
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 3 0.8660
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8651
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8651
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8641
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8641
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8588
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8588
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8579
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8579
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8570
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8570
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8537
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8537
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8503
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8503
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8469
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8469
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8453
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8453
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8442
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8442
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8364
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8364
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8333
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8333
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8230
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8230
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8215
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8215
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8205
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.8205
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8192
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8192
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8171
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8171
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8168
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8168
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8163
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8163
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8142
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8142
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8108
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8108
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8052
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8052
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8014
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8014
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7984
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7984
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7970
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7970
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7966
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7966
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7898
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7898
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7896
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7896
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7888
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7888
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7883
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7883
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7870
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7870
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7855
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7855
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7834
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7834
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7826
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7826
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7807
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.7807
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7786
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7786
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7779
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7779
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7772
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7772
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.7765
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.7765
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7761
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7761
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7756
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7756
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7753
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7753
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7733
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7733
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7720
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7720
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7701
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7701
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7694
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7694
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7675
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7675
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7654
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7654
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7651
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7651
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7644
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7644
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7639
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7639
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7635
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7635
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7613
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7613
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7609
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7609
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7606
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7606
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7603
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7603
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7602
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.7602
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7599
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7599
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7584
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7584
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7578
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7578
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7543
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7543
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7536
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7536
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7529
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7529
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7527
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.7527
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7524
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7524
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7522
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7522
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7516
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7516
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7494
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7494
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7493
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7493
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7492
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7492
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7486
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7486
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7469
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7469
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7464
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7464
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7447
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7447
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7430
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7430
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7425
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7425
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7420
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7420
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7419
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7419
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7419
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7419
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 3 0.7416
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 3 0.7416
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7391
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7391
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7391
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7391
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7390
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7390
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7382
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7382
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7376
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7376
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7353
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7353
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7339
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7339
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7332
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7332
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7328
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7328
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.7305
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.7305
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7297
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7297
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7285
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7285
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7274
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7274
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 3 0.7243
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 3 0.7243
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7239
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7239
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7238
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7238
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7236
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7236
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7225
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 3 0.7225
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7215
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7215
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7213
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7213
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7210
Ribonuclease TTHA0252 Q5SLP1 RNSE_THET8 Thermus thermophilus 3 0.7210
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7198
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7198
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7196
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7196
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7179
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7179
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7164
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7164
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7161
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7161
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7158
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7158
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7157
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7157
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7157
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7157
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7147
Bifunctional dihydrofolate reductase-thymidylate synthase Q27783 DRTS_TRYBB Trypanosoma brucei brucei 4 0.7147
Bifunctional dihydrofolate reductase-thymidylate synthase Q27783 DRTS_TRYBB Trypanosoma brucei brucei 4 0.7147
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 3 0.7147
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7134
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7134
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7116
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7116
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7113
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7113
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7103
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7103
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7088
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7088
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7088
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7088
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7087
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7087
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7085
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7085
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7083
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7083
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7077
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7077
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7075
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7075
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7073
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7073
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7069
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7069
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7058
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7058
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7050
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7050
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7032
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7032
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7031
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7031
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7026
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7026
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7026
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7026
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7023
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7023
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7022
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7022
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7010
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7010

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