5,7-dihydroxy-2',3',4'-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone - Compound Card

5,7-dihydroxy-2',3',4'-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone

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5,7-dihydroxy-2',3',4'-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone

Structure
Zoomed Structure
  • Family: Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(OC)c(OC)ccc1c1coc2c(c1=O)c(O)c(c(c2)O)CC=C(C)C
InChI InChI=1S/C23H24O7/c1-12(2)6-7-14-16(24)10-18-19(20(14)25)21(26)15(11-30-18)13-8-9-17(27-3)23(29-5)22(13)28-4/h6,8-11,24-25H,7H2,1-5H3
InChIKey DFQFPMVNBSTFQV-UHFFFAOYSA-N
Formula C23H24O7
HBA 7
HBD 2
MW 412.44
Rotatable Bonds 6
TPSA 98.36
LogP 4.41
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 30
Formal Charge 0
Fraction CSP3 0.26
Exact Mass 412.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Desmodium uncinatum Leguminosae/Fabaceae Plantae 225101

Showing of synonyms

  • Guchu SM, Yenesew A, et al. (2007). C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum.. Phytochemistry,2007,68(5),646-651. [View] [PubMed]
Pubchem: 102588656

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.67
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.840
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.88

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.250
Plasma Protein Binding
82.06
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.630
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.650
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.100
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.270
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-19.590
Rat (Acute)
2.190
Rat (Chronic Oral)
2.660
Fathead Minnow
5.440
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
494.500
Hydration Free Energy
-6.330
Log(D) at pH=7.4
3.030
Log(P)
5.11
Log S
-5.76
Log(Vapor Pressure)
-8.66
Melting Point
156.92
pKa Acid
7.77
pKa Basic
5.73
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9308
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9308
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9279
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9279
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8850
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8850
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8845
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8845
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8774
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8774
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8645
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8645
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8599
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8599
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8599
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8599
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8496
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8496
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8418
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8418
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8401
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8401
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8323
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.8323
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8274
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8274
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8252
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8252
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8200
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8200
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8190
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8190
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8151
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8151
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8103
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8103
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8098
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8098
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8095
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8095
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8090
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8090
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8015
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8015
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7980
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7980
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.7971
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.7971
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7906
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7906
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7872
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7872
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7859
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7859
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7845
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7845
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7810
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7810
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7805
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7805
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7799
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7799
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7789
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7789
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7779
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7779
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7768
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7768
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7766
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7766
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7761
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7761
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7755
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7755
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7737
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7737
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7729
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7729
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7718
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.7718
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7716
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7716
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7702
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7702
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7690
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7690
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7661
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7661
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7656
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7656
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7653
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7653
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7650
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7650
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7580
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7580
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7577
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7577
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7540
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7540
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7529
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7529
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7513
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7513
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7506
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7506
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7489
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7489
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7488
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.7488
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7484
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7484
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7472
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7472
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7457
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7457
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7438
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7438
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7438
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7438
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7430
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7430
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7409
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7409
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7390
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7390
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7368
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7368
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7355
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7355
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7323
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7323
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7321
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7321
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7319
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7319
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7318
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7318
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7304
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7304
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7299
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7299
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7296
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.7296
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7289
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7289
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7288
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7288
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7258
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7258
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7242
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7242
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7236
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7236
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7229
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7229
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7223
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7223
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.7219
Enoyl-acyl carrier protein reductase Q6TEI5 Q6TEI5_PLABE Plasmodium berghei 4 0.7219
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7213
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7213
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7198
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7198
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7197
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7197
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7193
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7193
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7183
Methionine adenosyltransferase 2 subunit beta Q9NZL9 MAT2B_HUMAN Homo sapiens 4 0.7183
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7153
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7153
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7138
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7138
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7134
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7134
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7134
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7134
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7114
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7114
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7092
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7092
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7086
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7086
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7085
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7085
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7074
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7074
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7067
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7067
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7066
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7066
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7062
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7062
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7060
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7060
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7057
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7057
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7050
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7050
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7042
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7042
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7038
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7038
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7037
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7037
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7036
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7036
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7035
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7035
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7029
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7029
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7026
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7026
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7025
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7025
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7024
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7024
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7008
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7008

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