5,4'-dihydroxy-7,2'-dimethoxy-6-methylisoflavanone - Compound Card

5,4'-dihydroxy-7,2'-dimethoxy-6-methylisoflavanone

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5,4'-dihydroxy-7,2'-dimethoxy-6-methylisoflavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(O)ccc1c1coc2c(c1=O)c(O)c(c(c2)OC)C
InChI InChI=1S/C18H16O6/c1-9-13(22-2)7-15-16(17(9)20)18(21)12(8-24-15)11-5-4-10(19)6-14(11)23-3/h4-8,19-20H,1-3H3
InChIKey YHQRQZPPJKXNBE-UHFFFAOYSA-N
Formula C18H16O6
HBA 6
HBD 2
MW 328.32
Rotatable Bonds 3
TPSA 89.13
LogP 3.2
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 328.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Desmodium uncinatum Leguminosae/Fabaceae Plantae 225101

Showing of synonyms

  • Guchu SM, Yenesew A, et al. (2007). C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum.. Phytochemistry,2007,68(5),646-651. [View] [PubMed]
Pubchem: 102588657

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 328.32 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 328.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 328.32 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.53
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.790
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.94

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.330
Plasma Protein Binding
81.35
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.610
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.660
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.110
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.880
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.410
Rat (Acute)
2.220
Rat (Chronic Oral)
2.300
Fathead Minnow
4.860
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
456.220
Hydration Free Energy
-11.460
Log(D) at pH=7.4
3.470
Log(P)
3.86
Log S
-5.91
Log(Vapor Pressure)
-7.89
Melting Point
205.24
pKa Acid
8.29
pKa Basic
4.91
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9562
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9562
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9509
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9509
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9438
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9438
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9353
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9353
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9330
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9330
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.9160
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 5 0.9160
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9124
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.9124
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9099
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 5 0.9099
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9019
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9019
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9002
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9002
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8879
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8879
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8831
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8831
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8798
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8798
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8740
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8740
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8735
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8735
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8685
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8685
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8610
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.8610
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8555
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8555
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8536
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8536
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8499
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.8499
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8465
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8465
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8449
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8449
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8444
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8444
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8443
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8443
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8435
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8435
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8388
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8388
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8345
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8345
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8295
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.8295
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8221
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8221
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8207
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8207
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8158
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8158
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8126
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8126
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8083
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8083
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8062
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8062
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8034
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8034
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8009
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8009
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7999
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7999
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7995
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7995
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7984
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7984
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7980
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.7961
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.7961
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7934
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7934
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7932
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7932
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7923
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7923
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7890
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7890
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7873
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7873
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7868
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7868
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7865
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7865
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7863
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7863
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7851
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7851
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7846
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7846
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7843
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7843
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7818
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.7818
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7793
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7793
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7767
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7767
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7726
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7726
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7720
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7720
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7717
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7717
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7715
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7715
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7714
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 4 0.7714
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.7711
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 4 0.7711
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7695
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7695
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 4 0.7684
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 4 0.7684
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7675
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7675
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7670
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7670
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7670
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7670
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7661
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7661
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7660
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7660
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7644
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7644
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7637
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7637
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7632
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7632
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7623
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7623
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7608
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7608
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7564
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7564
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7561
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7561
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7556
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7556
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7555
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7555
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7537
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7537
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7535
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7535
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7517
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7517
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7483
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7483
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7480
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7480
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7473
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7473
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7465
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7465
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7454
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7454
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7438
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7438
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7424
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7424
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7406
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7406
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7398
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7398
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7397
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7397
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7383
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7383
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7375
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7375
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7372
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7372
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7372
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7372
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7371
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7371
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7361
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7361
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7327
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7327
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7322
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7322
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7320
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7320
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7309
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7309
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7307
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7307
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7301
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7301
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7297
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7297
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7295
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7295
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7292
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7292
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7285
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7285
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7281
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7281
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7279
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7279
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7276
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7276
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7253
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7253
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7246
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7246
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7231
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7231
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7219
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7219
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7213
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7213
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7208
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7208
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7188
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7188
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7185
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7185
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7174
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7174
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7167
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.7167
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7148
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7148
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7129
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7129
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7129
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7129
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7129
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7129
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7114
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7114
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7089
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7089
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 4 0.7087
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 4 0.7087
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7086
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7086
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7084
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7084
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7074
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7074
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7072
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7072
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7066
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7066
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7066
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7066
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7066
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7066
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7053
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7053
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7045
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.7045
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7042
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7042
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7036
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7036
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7027
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7027
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7019
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7019
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7013
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7013
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7012
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7012
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7007
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 3 0.7007

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