(S)-3,4',5-trihydroxy-2',7-dimethoxy-3'-prenylisoflavanone - Compound Card

(S)-3,4',5-trihydroxy-2',7-dimethoxy-3'-prenylisoflavanone

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(S)-3,4',5-trihydroxy-2',7-dimethoxy-3'-prenylisoflavanone

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(O)c2c(c1)OC[C@@](C2=O)(O)c1ccc(c(c1OC)CC=C(C)C)O
InChI InChI=1S/C22H24O7/c1-12(2)5-6-14-16(23)8-7-15(20(14)28-4)22(26)11-29-18-10-13(27-3)9-17(24)19(18)21(22)25/h5,7-10,23-24,26H,6,11H2,1-4H3/t22-/m1/s1
InChIKey JTJQHIJZMZOLER-JOCHJYFZSA-N
Formula C22H24O7
HBA 7
HBD 3
MW 400.43
Rotatable Bonds 5
TPSA 105.45
LogP 3.09
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 29
Formal Charge 0
Fraction CSP3 0.32
Exact Mass 400.15
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dalbergia melanoxylon Leguminosae/Fabaceae Plantae 114981

Showing of synonyms

  • Mutai P, Heydenreich M, et al. (2013). 3-Hydroxyisoflavanones from the stem bark of Dalbergia melanoxylon: Isolation, antimycobacterial evaluation and molecular docking studies.. Phytochemistry Letters,2013,30,6(4),671-675. [View] [PubMed]
Pubchem: 102105357

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OCC(C2=O)c3ccccc3

Level: 1

Mol. Weight: 400.43 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 400.43 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 400.43 g/mol

Antimycobacterial

Absorption

Caco-2 (logPapp)
-5.16
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.850
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.79

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.970
Plasma Protein Binding
71.28
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
13.280
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.600
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.510
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.370
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-10.380
Rat (Acute)
2.070
Rat (Chronic Oral)
3.000
Fathead Minnow
4.810
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
447.360
Hydration Free Energy
-7.810
Log(D) at pH=7.4
2.970
Log(P)
4.24
Log S
-5.53
Log(Vapor Pressure)
-8.08
Melting Point
155.04
pKa Acid
7.81
pKa Basic
4.64
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9350
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9350
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9249
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9249
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9041
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9041
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8851
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8851
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8726
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.8726
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8713
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8713
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8712
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8712
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8710
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8710
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8685
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8685
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8669
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8669
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.8561
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.8561
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8524
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8524
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8521
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8521
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8513
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8513
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8498
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8498
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8467
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8467
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8447
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8447
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8425
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8425
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8317
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8317
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8278
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8278
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8225
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8225
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8153
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8153
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8147
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8147
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8121
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8121
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8118
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.8118
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8103
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8103
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8099
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.8099
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8069
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8069
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8064
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8064
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8027
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8027
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8013
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8013
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8011
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8011
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7999
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7999
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7995
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7995
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7992
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7992
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 3 0.7935
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 3 0.7935
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7924
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.7924
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7923
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 4 0.7923
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7866
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7866
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7842
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7842
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7838
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7838
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7806
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7806
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7796
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7796
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7743
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7743
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7717
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 3 0.7717
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7705
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7705
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7694
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7694
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7691
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7691
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7690
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7690
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7685
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7685
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7680
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7680
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7669
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7669
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7667
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7667
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7663
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7663
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7657
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7657
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7650
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7650
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7623
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7623
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7622
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7622
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7587
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7587
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 4 0.7563
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 4 0.7563
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7528
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7528
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7523
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7523
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7509
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7509
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7485
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7485
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7479
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7479
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7442
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7442
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7434
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7434
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7428
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7428
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7425
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7425
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7414
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7414
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7410
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7410
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7406
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7406
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7400
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7400
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7387
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7387
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7382
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7382
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7365
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7365
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7344
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7344
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7336
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7336
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7333
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7333
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7324
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7324
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7323
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7323
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7294
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7294
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7286
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7286
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7277
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7277
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7268
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7268
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7248
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7248
GMP synthase [glutamine-hydrolyzing] Q8IJR9 Q8IJR9_PLAF7 Plasmodium falciparum 4 0.7245
GMP synthase [glutamine-hydrolyzing] Q8IJR9 Q8IJR9_PLAF7 Plasmodium falciparum 4 0.7245
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7209
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7209
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7208
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7208
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7206
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7206
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7200
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7200
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7197
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7197
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7196
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7196
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7191
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7191
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7190
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7190
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7172
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7172
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7168
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7168
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7168
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 3 0.7168
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7165
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7165
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7138
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7138
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.7134
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.7134
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7124
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7124
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7107
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7107
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7103
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7103
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7096
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7096
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7069
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7069
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7007
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7007
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7006
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7006

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