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(-)-mesquitol

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavonol

Canonical Smiles	O[C@H]1Cc2ccc(c(c2O[C@@H]1c1ccc(c(c1)O)O)O)O
InChI	InChI=1S/C15H14O6/c16-9-3-1-7(5-11(9)18)14-12(19)6-8-2-4-10(17)13(20)15(8)21-14/h1-5,12,14,16-20H,6H2/t12-,14+/m0/s1
InChIKey	TXULLYMENMRLHL-GXTWGEPZSA-N
Formula	C₁₅H₁₄O₆
HBA	6
HBD	5
MW	290.27
Rotatable Bonds	1
TPSA	110.38
LogP	1.55
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.2
Exact Mass	290.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Prosopis juliflora	Leguminosae/Fabaceae	Plantae	3128859

Showing of synonyms

Sirmah P1, Dumarçay S, et al. (2013). Unusual amount of (-)-mesquitol from the heartwood of Prosopis juliflora.. Phytochemistry Letters,2013,30,6(4),671-675. [View] [PubMed]

Pubchem: 11033582

Cas: 109671-55-8

Chebi: 196279

Nmrshiftdb2: 60067782

No compound-protein relationship available.

SMILES: c1cccc(c12)OC(CC2)c3ccccc3

Level: 1

Mol. Weight: 290.27 g/mol

SMILES: C1CCOc(c12)cccc2

Level: 0

Mol. Weight: 290.27 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 290.27 g/mol

Antioxidant

Absorption

Caco-2 (logPapp): -5.73
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.1
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.0

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.74
Plasma Protein Binding: 84.03
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 13.31
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.31
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.72
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 5.16
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.57
Rat (Acute): 2.14
Rat (Chronic Oral): 3.06
Fathead Minnow: 3.98
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 440.96
Hydration Free Energy: -11.33
Log(D) at pH=7.4: 1.37
Log(P): 0.98
Log S: -2.18
Log(Vapor Pressure): -8.37
Melting Point: 239.84
pKa Acid: 6.22
pKa Basic: 5.93

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9553
Multidrug-efflux transporter 1 regulator	P39075	BMRR_BACSU	Bacillus subtilis	3	0.9553
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.9055
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	3	0.9055
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8930
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8930
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8917
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8917
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8859
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8859
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8852
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8852
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8826
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8826
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.8818
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.8818
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8776
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8776
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8647
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8647
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8633
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8633
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8623
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8623
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8590
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8590
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8566
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8566
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.8542
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	3	0.8542
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8492
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8492
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.8441
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.8441
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8432
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8432
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8418
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8418
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8406
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8406
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8390
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8390
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.8364
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	3	0.8364
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8359
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8359
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.8345
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	4	0.8345
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8340
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.8340
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8335
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8335
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	4	0.8270
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	4	0.8270
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8249
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8249
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	6	0.8230
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	6	0.8230
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8224
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8224
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8194
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8194
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8189
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8189
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8184
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8184
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.8180
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.8180
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8165
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8165
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8164
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8164
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8150
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8150
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8109
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8109
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	4	0.8072
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8072
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	4	0.8072
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8072
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8068
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8068
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8065
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8065
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8054
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8054
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8050
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8050
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8048
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8048
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8015
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8015
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8009
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8009
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8007
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8007
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7993
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7993
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7992
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7992
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7963
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7963
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	4	0.7962
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	4	0.7962
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7958
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7958
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.7935
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.7935
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7931
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	3	0.7931
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7917
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7917
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7908
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7908
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7845
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.7845
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7842
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7842
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7814
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.7814
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7800
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7800
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7799
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7799
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7794
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7794
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	4	0.7777
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	4	0.7777
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7776
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7776
Reticuline oxidase	P30986	RETO_ESCCA	Eschscholzia californica	4	0.7724
Reticuline oxidase	P30986	RETO_ESCCA	Eschscholzia californica	4	0.7724
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7722
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7722
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7701
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7701
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7690
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7690
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7689
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7689
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7667
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.7667
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7631
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7631
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7626
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7626
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7610
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7610
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7606
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7606
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7576
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7576
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7576
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7576
Primosomal protein N'	A6TGC5	A6TGC5_KLEP7	Klebsiella pneumoniae subsp. pneumoniae	4	0.7571
Primosomal protein N'	A6TGC5	A6TGC5_KLEP7	Klebsiella pneumoniae subsp. pneumoniae	4	0.7571
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7566
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7566
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.7560
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.7560
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7559
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7559
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7546
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7546
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7496
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7496
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7488
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7488
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	5	0.7484
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	5	0.7484
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7483
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.7483
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7481
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7481
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7477
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7477
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7476
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7476
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7469
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7469
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7458
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7458
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7456
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7456
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7440
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7440
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7433
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7433
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7403
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.7403
Quercetin 2,3-dioxygenase	Q7SIC2	QDOI_ASPJA	Aspergillus japonicus	4	0.7403
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7403
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	5	0.7393
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	5	0.7393
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7389
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7389
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7385
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7385
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7379
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7379
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7361
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7361
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7360
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7360
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7324
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7324
Reticuline oxidase	P30986	RETO_ESCCA	Eschscholzia californica	5	0.7316
Reticuline oxidase	P30986	RETO_ESCCA	Eschscholzia californica	5	0.7316
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7292
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7292
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7289
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7289
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7280
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7280
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7272
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7272
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7260
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7260
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7257
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7257
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7251
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7251
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7223
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7223
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7211
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7211
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	4	0.7208
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	4	0.7208
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7207
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7207
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7193
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7193
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7190
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7190
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.7188
Beta-glucosidase 1A	Q25BW5	BGL1A_PHACH	Phanerodontia chrysosporium	3	0.7188
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7185
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7185
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7175
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7175
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7174
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7174
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	4	0.7165
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	4	0.7165
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7151
Prolyl tripeptidyl peptidase	Q7MUW6	PTP_PORGI	Porphyromonas gingivalis	3	0.7151
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7144
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7144
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7134
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7134
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7119
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7119
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7114
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7114
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7104
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7104
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7096
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7096
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7096
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7096
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7094
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7094
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	4	0.7086
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	4	0.7086
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7083
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7083
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7082
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7082
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7077
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7077
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7074
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7074
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7070
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7070
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7066
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7066
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7056
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7056
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7055
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7055
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7046
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7046
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7044
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7044
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7039
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7039
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7026
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7026
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7021
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7021
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7014
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7014
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7000
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7000

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