17-O-acetyl,10-hydroxycorynantheol - Compound Card

17-O-acetyl,10-hydroxycorynantheol

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17-O-acetyl,10-hydroxycorynantheol

Structure
Zoomed Structure
  • Family: Plantae - Loganiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Indole Alkaloid
Canonical Smiles C=C[C@H]1CN2CCc3c([C@@H]2C[C@@H]1CCOC(=O)C)[nH]c1c3cc(cc1)O
InChI InChI=1S/C21H26N2O3/c1-3-14-12-23-8-6-17-18-11-16(25)4-5-19(18)22-21(17)20(23)10-15(14)7-9-26-13(2)24/h3-5,11,14-15,20,22,25H,1,6-10,12H2,2H3/t14-,15-,20-/m0/s1
InChIKey VUUACRJZBMDYES-AVYPCKFXSA-N
Formula C21H26N2O3
HBA 4
HBD 2
MW 354.45
Rotatable Bonds 4
TPSA 65.56
LogP 3.55
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.48
Exact Mass 354.19
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Strychnos usambarensis Loganiaceae Plantae 992791

Showing of synonyms

  • Cao M, Muganga R, et al. (2011). 17-O-acetyl,10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves.. Planta Medica,2011,77(18),2050-2053. [View] [PubMed]
Pubchem: 56935638

No compound-protein relationship available.

Structure

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 354.45 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-5.12
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.08
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-1.52

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.43
Plasma Protein Binding
60.51
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
14.68
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.57
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.45
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.86
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-4.99
Rat (Acute)
2.68
Rat (Chronic Oral)
2.07
Fathead Minnow
3.97
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
434.5
Hydration Free Energy
-7.36
Log(D) at pH=7.4
3.14
Log(P)
3.3
Log S
-3.53
Log(Vapor Pressure)
-9.55
Melting Point
213.29
pKa Acid
9.36
pKa Basic
7.04
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9626
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9626
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9541
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9541
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.9365
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.9365
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9282
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9282
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.9054
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.9054
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.9031
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.9031
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8847
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8847
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8804
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8804
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8753
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8753
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8732
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8732
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8715
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8715
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8690
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8690
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8646
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8646
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8635
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8635
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.8633
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.8633
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8554
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8554
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8540
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8540
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8528
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8528
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8487
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8487
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8479
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8479
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8442
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8442
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8440
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8440
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8337
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8337
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8332
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8332
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8320
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.8320
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8310
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8310
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8190
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8190
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8190
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8190
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8148
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8148
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 3 0.8085
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 3 0.8085
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8054
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8054
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7937
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7937
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7918
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7918
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7745
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7745
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7739
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7739
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7731
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7731
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7720
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7720
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7693
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7693
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7680
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7680
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7659
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7659
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7645
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7645
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7621
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7621
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7593
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7593
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7588
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7588
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7568
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7568
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7558
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7558
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7537
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7537
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7526
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7526
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7511
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7511
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7505
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7505
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7494
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7494
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7491
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7491
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7488
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7488
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7452
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7452
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7441
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7441
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 2 0.7436
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 2 0.7436
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7434
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7434
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7426
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7426
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7405
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7405
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7403
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7403
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7374
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7374
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7367
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7367
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7360
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7360
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7359
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 3 0.7359
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7345
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7345
Phosphoglycerate kinase 1 P00558 PGK1_HUMAN Homo sapiens 3 0.7343
Phosphoglycerate kinase 1 P00558 PGK1_HUMAN Homo sapiens 3 0.7343
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7342
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7342
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7341
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7341
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7332
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7332
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7330
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7330
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7325
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7325
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7305
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7305
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7302
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7302
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7301
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7301
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 3 0.7300
Toluene-4-monooxygenase system, hydroxylase component subunit alpha Q00456 TMOA_PSEME Pseudomonas mendocina 3 0.7300
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7299
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7299
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7293
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7293
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7285
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7285
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7284
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7284
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7281
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7281
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7279
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.7279
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7263
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7263
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7257
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 3 0.7257
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7253
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7253
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7250
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7250
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7249
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 2 0.7249
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7237
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7237
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7232
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7232
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7232
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7232
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7229
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7229
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7221
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7221
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7219
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7219
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7219
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7219
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 4 0.7218
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 4 0.7218
Phosphoglycerate kinase Q83AU6 PGK_COXBU Coxiella burnetii 3 0.7216
Phosphoglycerate kinase Q83AU6 PGK_COXBU Coxiella burnetii 3 0.7216
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7215
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7215
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7214
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7214
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7204
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7204
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7201
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7201
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7199
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7199
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7198
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7198
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7195
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7195
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7188
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7188
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7186
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7186
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7184
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7184
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7177
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7177
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7175
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7175
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7175
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7175
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7174
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7174
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7165
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7165
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7148
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7148
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7141
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7141
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7134
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7134
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7125
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7125
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7117
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7117
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7116
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7116
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7107
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7107
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7106
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7106
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7103
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7103
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7090
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7090
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7088
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7088
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7086
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7086
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7084
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7084
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7072
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7072
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7067
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7067
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7056
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7056
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7054
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7054
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7053
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7053
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7052
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7052
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7051
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7051
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7049
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7049
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7042
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7042
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7039
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7039
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7027
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7027
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7023
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7023
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7016
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7016
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7014
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7014
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7010
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7010
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7006
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7006
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7005
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7005
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7003
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7003

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