10-hydroxy-Nb-methylcorynantheol - Compound Card

10-hydroxy-Nb-methylcorynantheol

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10-hydroxy-Nb-methylcorynantheol

Structure
Zoomed Structure
  • Family: Plantae - Loganiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Indole Alkaloid
Canonical Smiles OCC[C@H]1C[C@@H]2N(C[C@@H]1C=C)CCc1c2[nH]c2c1cc(cc2)O
InChI InChI=1S/C19H24N2O2/c1-2-12-11-21-7-5-15-16-10-14(23)3-4-17(16)20-19(15)18(21)9-13(12)6-8-22/h2-4,10,12-13,18,20,22-23H,1,5-9,11H2/t12-,13-,18-/m0/s1
InChIKey OLPVNUOVLSPTMQ-LXIYXOSZSA-N
Formula C19H24N2O2
HBA 3
HBD 3
MW 312.41
Rotatable Bonds 3
TPSA 59.49
LogP 2.98
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.47
Exact Mass 312.18
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Strychnos usambarensis Loganiaceae Plantae 992791

Showing of synonyms

  • Cao M, Muganga R, et al. (2011). 17-O-acetyl,10-hydroxycorynantheol, a selective antiplasmodial alkaloid isolated from Strychnos usambarensis leaves.. Planta Medica,2011,77(18),2050-2053. [View] [PubMed]
Pubchem: 132576238

No compound-protein relationship available.

Structure

SMILES: C1CCCN(CC2)C1c(c2c34)[nH]c3cccc4

Level: 0

Mol. Weight: 312.41 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-5.34
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-5.310
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-1.46

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.220
Plasma Protein Binding
59.4
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
17.240
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.430
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.470
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
4.870
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-0.670
Rat (Acute)
2.650
Rat (Chronic Oral)
2.350
Fathead Minnow
3.970
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
424.650
Hydration Free Energy
-8.730
Log(D) at pH=7.4
2.320
Log(P)
2.67
Log S
-3.0
Log(Vapor Pressure)
-9.61
Melting Point
212.35
pKa Acid
10.39
pKa Basic
7.55
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9515
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9515
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9504
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9504
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.9352
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.9352
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9100
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9100
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.9049
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.9049
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8865
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.8865
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8734
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8734
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8724
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8724
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8712
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.8712
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8638
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8638
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8603
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8603
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.8600
Beta-galactoside-specific lectin 1 P81446 ML1_VISAL Viscum album 3 0.8600
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8586
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8586
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8528
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8528
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8513
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8513
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8500
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8500
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8482
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8482
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.8462
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 3 0.8462
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8458
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8458
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8446
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8446
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8424
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8424
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8340
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8340
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8296
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8296
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8209
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8209
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8148
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8148
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 3 0.8085
Short form salivary protein D7R4 Q7PNF2 Q9BIH3_ANOGA Anopheles gambiae 3 0.8085
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8021
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8021
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7904
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7904
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7845
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.7845
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7804
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7804
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7771
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7771
Alpha amylase B8CZ54 B8CZ54_HALOH Halothermothrix orenii 3 0.7741
Alpha amylase B8CZ54 B8CZ54_HALOH Halothermothrix orenii 3 0.7741
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7727
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7727
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7716
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7716
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7644
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7644
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7638
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7638
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7582
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7582
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7567
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7567
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7498
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7498
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7425
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7425
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7420
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7420
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7407
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7407
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7390
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7390
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7382
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7382
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7372
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7372
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7368
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7368
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7348
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7348
Phosphoglycerate kinase 1 P00558 PGK1_HUMAN Homo sapiens 3 0.7343
Phosphoglycerate kinase 1 P00558 PGK1_HUMAN Homo sapiens 3 0.7343
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7342
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7342
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7341
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7341
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7339
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7339
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7333
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7333
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7323
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7323
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7320
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 3 0.7320
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7319
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7319
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7303
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7303
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7301
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7301
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7299
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7299
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7292
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 3 0.7292
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7284
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7284
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7282
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7282
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7270
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7270
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7265
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7265
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7229
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 3 0.7229
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7227
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7227
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7221
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7221
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7209
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 3 0.7209
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7209
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7209
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7206
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7206
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7202
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7201
Poly [ADP-ribose] polymerase 1 P26446 PARP1_CHICK Gallus gallus 3 0.7201
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7194
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7194
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7193
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7193
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7191
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7191
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7182
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7182
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7174
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7174
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7172
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7172
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7168
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7168
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7161
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7161
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7159
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7159
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7155
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7155
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7151
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7151
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 4 0.7147
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 4 0.7147
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7147
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7147
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7129
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7129
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7125
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 2 0.7125
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7093
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7093
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7090
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7090
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7087
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7087
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7085
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7085
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7064
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7064
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7054
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7054
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7046
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7046
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7029
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7029
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7023
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7023
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7022
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7022
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7020
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7020
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7006
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7006
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7003
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7003

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