Ekeberin D1 - Compound Card

Ekeberin D1

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Ekeberin D1

Structure
Zoomed Structure
  • Family: Meliaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Triterpenoid
Canonical Smiles CC(=O)O[C@@H](C(O)(C)C)CC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CC[C@H](C(O)(C)C)O)\C)\C)/C)/C
InChI InChI=1S/C32H56O5/c1-24(16-12-18-26(3)20-22-29(34)31(6,7)35)14-10-11-15-25(2)17-13-19-27(4)21-23-30(32(8,9)36)37-28(5)33/h14-15,18-19,29-30,34-36H,10-13,16-17,20-23H2,1-9H3/b24-14+,25-15+,26-18+,27-19+/t29-,30-/m1/s1
InChIKey BKHZEULGRLICQT-AUAGCXQPSA-N
Formula C32H56O5
HBA 5
HBD 3
MW 520.8
Rotatable Bonds 18
TPSA 86.99
LogP 7.51
Number Rings 0
Number Aromatic Rings 0
Heavy Atom Count 37
Formal Charge 0
Fraction CSP3 0.72
Exact Mass 520.41
Number of Lipinski Rule Violations 2
# Species Family Kingdom NCBI Taxonomy ID
1 Ekebergia capensis Meliaceae Plantae 124949

Showing of synonyms

  • Murata T, Miyase T, et al. (2008). Antiplasmodial triterpenoids from Ekebergia capensis.. Journal of Natural Products,2008,71(2),167-174. [View] [PubMed]
Pubchem: 24801245
Nmrshiftdb2: 60114458

No compound-protein relationship available.

No scaffolds available.

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.8
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.95
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-3.22

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.96
Plasma Protein Binding
47.17
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
-1.77
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.25
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.58
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
6.79
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-138.93
Rat (Acute)
1.52
Rat (Chronic Oral)
2.3
Fathead Minnow
6.55
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
472.42
Hydration Free Energy
-3.01
Log(D) at pH=7.4
3.75
Log(P)
6.92
Log S
-5.46
Log(Vapor Pressure)
-7.96
Melting Point
65.32
pKa Acid
11.43
pKa Basic
6.07
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.9539
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.9539
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9457
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9457
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.9446
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.9446
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9253
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9253
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9149
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9149
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9124
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9124
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9032
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9032
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8937
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8937
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8858
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8858
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8821
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8821
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8793
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8793
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8730
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8730
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8703
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8703
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.8660
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.8660
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8487
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8487
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8454
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8454
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8416
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8416
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8403
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8403
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8382
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8382
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8351
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8351
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8318
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8318
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8284
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8284
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8190
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8190
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8112
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8112
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8104
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8104
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.8078
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.8078
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8067
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8067
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8018
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8018
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8007
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8007
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7957
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7957
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7955
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7955
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7954
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7954
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7952
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7952
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7952
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7952
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7945
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7945
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7920
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7920
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7908
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7908
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7896
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7896
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7852
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7852
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7816
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7816
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7806
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7806
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7798
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7798
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 4 0.7795
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 4 0.7795
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 4 0.7795
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 4 0.7795
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7789
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7789
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7787
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7787
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7759
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7759
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7755
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7755
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7750
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7750
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7701
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7701
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7691
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7691
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7681
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7681
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7675
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7675
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7638
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7638
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7623
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7623
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7619
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7619
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7606
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7606
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7604
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7604
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7600
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7600
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7594
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.7594
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7588
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7588
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7571
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7571
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7550
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7550
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7549
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7549
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7537
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7537
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7534
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7534
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7521
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7521
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7487
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7487
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7482
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7482
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7480
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7480
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7468
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7468
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7449
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7449
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7446
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7446
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7442
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7442
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7440
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7440
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7424
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7424
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7423
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7423
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7410
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7410
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7393
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7393
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7384
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7384
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7376
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7376
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7372
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7372
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7348
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7348
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7342
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7342
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7339
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7339
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.7330
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.7330
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7322
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7322
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7308
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7308
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7298
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7298
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7289
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7289
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7280
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7280
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7276
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7276
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7270
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7270
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7269
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7269
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7268
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7268
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7267
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7267
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7256
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7256
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7245
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7245
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7243
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7243
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7242
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7242
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7207
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7207
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7206
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7206
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.7204
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.7204
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7203
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7203
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7169
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7169
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7167
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7167
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7166
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7166
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7158
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7158
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 4 0.7151
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 4 0.7151
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7147
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7147
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7146
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7146
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7145
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7145
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7138
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7138
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7116
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7116
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7098
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7098
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7087
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7087
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.7077
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.7077
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7073
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7073
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7068
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7068
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7064
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7064
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7051
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7051
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7048
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7048
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.7046
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.7046
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7039
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7039
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7038
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7038
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7033
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7033
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7026
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7026
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7022
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7022
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7019
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7019
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7012
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7012
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7007
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7007

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