2,3,22,23-tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene (3R,22R) - Compound Card

2,3,22,23-tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene (3R,22R)

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2,3,22,23-tetrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene (3R,22R)

Structure
Zoomed Structure
  • Family: Plantae - Meliaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Acyclic Triterpenoid
Canonical Smiles O[C@@H](C(O)(C)C)CC/C(=C/CC/C(=C/CC/C=C(/CC/C=C(/CC[C@H](C(O)(C)C)O)\C)\C)/C)/C
InChI InChI=1S/C30H54O4/c1-23(15-11-17-25(3)19-21-27(31)29(5,6)33)13-9-10-14-24(2)16-12-18-26(4)20-22-28(32)30(7,8)34/h13-14,17-18,27-28,31-34H,9-12,15-16,19-22H2,1-8H3/b23-13+,24-14+,25-17+,26-18+/t27-,28-/m1/s1
InChIKey NPWAQSYSDCQSKY-LYINBSFCSA-N
Formula C30H54O4
HBA 4
HBD 4
MW 478.76
Rotatable Bonds 17
TPSA 80.92
LogP 6.94
Number Rings 0
Number Aromatic Rings 0
Heavy Atom Count 34
Formal Charge 0
Fraction CSP3 0.73
Exact Mass 478.4
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Ekebergia capensis Meliaceae Plantae 124949

Showing of synonyms

  • Murata T, Miyase T, et al. (2008). Antiplasmodial triterpenoids from Ekebergia capensis.. Journal of Natural Products,2008,71(2),167-174. [View] [PubMed]
Pubchem: 11465741
Nmrshiftdb2: 70129817

No compound-protein relationship available.

No scaffolds available.

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.9
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.8
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-3.58

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.18
Plasma Protein Binding
39.78
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
-1.45
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.15
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.07
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.57
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-37.43
Rat (Acute)
1.53
Rat (Chronic Oral)
2.43
Fathead Minnow
6.24
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
460.45
Hydration Free Energy
-4.2
Log(D) at pH=7.4
3.72
Log(P)
6.26
Log S
-5.1
Log(Vapor Pressure)
-8.27
Melting Point
85.55
pKa Acid
10.84
pKa Basic
6.61
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.9670
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.9670
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9650
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9650
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.9475
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.9475
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9441
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9441
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.9109
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.9109
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9035
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9035
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8901
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8901
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8871
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8871
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8792
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8792
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8774
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.8774
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.8754
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.8754
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8688
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.8688
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8650
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8650
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8648
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8648
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8621
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8621
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8580
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8580
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8533
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8533
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8472
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8472
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.8370
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.8370
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.8353
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.8353
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.8349
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.8349
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.8348
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 3 0.8348
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8196
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8196
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8140
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8140
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8088
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.8088
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8074
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8074
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8039
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8039
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8020
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8020
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.8004
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.8004
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7973
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7973
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7969
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.7969
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.7967
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.7967
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7951
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7951
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7946
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7946
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7940
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7940
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7926
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 3 0.7926
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7920
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7920
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7915
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7915
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7899
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7899
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7846
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7846
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7807
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7807
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7761
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7761
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7739
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7739
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7730
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7730
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7712
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7712
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7706
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7706
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7699
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7699
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7658
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7658
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7656
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7656
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7650
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7650
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7641
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7641
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7635
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7635
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7619
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7619
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7613
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.7613
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.7613
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7613
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7610
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7610
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7607
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.7607
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7604
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7604
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 4 0.7602
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 4 0.7602
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7595
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7595
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7567
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7567
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7563
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7563
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 3 0.7560
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 3 0.7560
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7550
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.7550
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 3 0.7510
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 3 0.7510
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7502
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7502
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7461
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7461
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 3 0.7457
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 3 0.7457
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7451
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7451
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7444
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7444
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7438
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7438
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7435
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7435
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7433
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7433
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7423
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7423
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7416
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7416
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7414
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7414
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7411
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7411
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7396
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7396
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7387
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7387
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7375
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7375
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7374
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7374
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7348
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7348
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7346
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7346
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7343
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7343
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7335
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7335
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7328
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7328
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7317
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7317
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7300
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7300
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7297
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7297
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7292
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7292
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7288
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7288
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7284
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7284
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7284
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7284
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7252
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7252
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7241
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.7241
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7235
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7235
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 4 0.7234
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 4 0.7234
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7232
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7232
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7223
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7223
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 4 0.7216
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 4 0.7216
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7216
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7216
Cartilage oligomeric matrix protein Q9R0G6 COMP_MOUSE Mus musculus 3 0.7215
Cartilage oligomeric matrix protein Q9R0G6 COMP_MOUSE Mus musculus 3 0.7215
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 3 0.7210
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 3 0.7210
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7209
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7209
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7199
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7199
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7197
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7197
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7191
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7191
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7177
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7177
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7153
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7153
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7151
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7151
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7150
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7150
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7150
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7150
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7148
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7148
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7142
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 4 0.7142
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7130
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7130
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7123
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7123
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7107
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.7107
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7093
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7093
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7089
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7089
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7084
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7084
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7072
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7072
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7045
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7045
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.7043
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 3 0.7043
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7043
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7043
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7032
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7032
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7028
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.7028
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7026
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7026
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7011
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7011
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7004
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7004

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