1,7-dihydroxy-4-methoxyxanthone - Compound Card

1,7-dihydroxy-4-methoxyxanthone

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1,7-dihydroxy-4-methoxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Polygalaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1ccc(c2c1oc1ccc(cc1c2=O)O)O
InChI InChI=1S/C14H10O5/c1-18-11-5-3-9(16)12-13(17)8-6-7(15)2-4-10(8)19-14(11)12/h2-6,15-16H,1H3
InChIKey YDZGWMWSKOGVLG-UHFFFAOYSA-N
Formula C14H10O5
HBA 5
HBD 2
MW 258.23
Rotatable Bonds 1
TPSA 79.9
LogP 2.37
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 258.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Securidaca longepedunculata Polygalaceae Plantae 690845

Showing of synonyms

  • Joseph CC, Moshi MJ, et al. (2006). (4-Methoxy-benzo[1,3]dioxol-5-yl)-Phenylmethanone: an antibacterial benzophenone from Securidaca longepedunculata.. African Journal of Traditional, Complementary and Alternative Medicines,2006,3(3),80-86. [View] [PubMed]
Pubchem: 5465785
Chebi: 67553
Nmrshiftdb2: 60064842
Metabolights: MTBLC67553
Bindingdb: 50485132

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 258.23 g/mol

Antibacterial

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.600
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.5

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.310
Plasma Protein Binding
73.49
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.320
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.320
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.800
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.410
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.770
Rat (Acute)
2.120
Rat (Chronic Oral)
2.580
Fathead Minnow
4.560
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
413.650
Hydration Free Energy
-10.630
Log(D) at pH=7.4
2.640
Log(P)
3.01
Log S
-4.1
Log(Vapor Pressure)
-7.13
Melting Point
231.47
pKa Acid
7.94
pKa Basic
3.54
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9499
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9499
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9409
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.9409
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9250
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9250
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.9185
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.9185
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9178
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9178
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9174
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9174
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9169
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9169
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.9055
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.9055
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8997
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8997
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8958
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8958
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8933
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8933
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8890
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8890
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8864
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8864
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8791
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8791
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8769
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8769
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8755
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8755
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8720
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8720
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8709
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8709
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8704
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8704
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8647
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8647
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8639
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8639
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8583
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8583
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8562
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8562
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8561
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8542
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8542
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8502
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8502
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8455
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8455
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8451
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8451
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8446
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8446
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8400
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8400
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8345
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8345
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8329
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8329
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8315
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8315
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8291
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8291
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8274
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8274
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8258
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8258
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8248
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8248
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8246
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8246
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8244
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8244
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8229
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8229
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8201
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8201
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8193
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8193
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8167
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8167
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8108
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8108
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8051
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8051
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8041
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8041
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8028
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8028
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8023
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8023
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7991
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7991
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7974
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7974
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7969
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.7969
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7946
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7946
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7929
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7929
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7925
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7925
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7917
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7917
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7892
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7892
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7874
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7874
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7857
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7857
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7839
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7839
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7823
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7823
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7812
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7812
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7799
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7799
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7775
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7775
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7762
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7762
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7738
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7738
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7729
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7729
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7707
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7707
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7705
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7705
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7704
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7704
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7704
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7704
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7695
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7695
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7690
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7690
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7679
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7679
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7678
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7678
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7668
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7668
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7665
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7665
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7638
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7638
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7619
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7619
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7617
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7617
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7602
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7602
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7597
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7597
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7587
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7587
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7585
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7585
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7580
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7580
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7578
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7578
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7564
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7564
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7563
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7563
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7543
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7543
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7542
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7542
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7536
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7536
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7526
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7526
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7494
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7494
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7488
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7488
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7480
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7480
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7470
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7470
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7466
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7466
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7465
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7465
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7452
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7452
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7449
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7449
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7423
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7423
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7374
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7374
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7373
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7373
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7368
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7368
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7365
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7365
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7354
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7354
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7353
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7353
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7348
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7348
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7344
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7344
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7328
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7328
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7319
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7319
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7319
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7319
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7310
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7310
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7309
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7309
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7295
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7295
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7292
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7292
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7289
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7289
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7283
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7283
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7280
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7280
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7279
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7279
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7273
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7273
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7272
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7272
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7265
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7265
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7261
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7261
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7257
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7257
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7252
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7252
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7250
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7250
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7245
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7245
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7240
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7240
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7235
Leucine--tRNA ligase P07813 SYL_ECOLI Escherichia coli 3 0.7235
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7219
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7219
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7210
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7210
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7207
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7207
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7206
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7206
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7195
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7195
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7195
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7195
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7193
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7193
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7192
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7192
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7182
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7182
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7172
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7172
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7159
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7159
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7156
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7156
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7153
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7153
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7139
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7139
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7128
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7128
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7121
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7121
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7120
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7120
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7117
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7117
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7106
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7106
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7105
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7105
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7098
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7098
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7094
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7094
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7090
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7090
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7088
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7088
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7082
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7082
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7070
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7070
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7067
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7066
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7066
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7060
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7060
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 3 0.7054
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 3 0.7054
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7050
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7050
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7047
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7047
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7043
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7043
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7040
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7040
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7034
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7034
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7034
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7034
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7032
Serine/threonine-protein kinase Nek2 P51955 NEK2_HUMAN Homo sapiens 3 0.7032
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7026
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7026
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7018
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7018
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7010
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7010
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7008
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7008
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7007
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7007
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7005
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7005
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7000
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7000
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7000
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7000

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