2',4'-dihydroxy-3',6'-dimethoxychalcone - Compound Card

2',4'-dihydroxy-3',6'-dimethoxychalcone

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2',4'-dihydroxy-3',6'-dimethoxychalcone

Structure
Zoomed Structure
  • Family: Plantae - Polygonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(O)c(c(c1C(=O)/C=C/c1ccccc1)O)OC
InChI InChI=1S/C17H16O5/c1-21-14-10-13(19)17(22-2)16(20)15(14)12(18)9-8-11-6-4-3-5-7-11/h3-10,19-20H,1-2H3/b9-8+
InChIKey BXMWIRIMYNWIGQ-CMDGGOBGSA-N
Formula C17H16O5
HBA 5
HBD 2
MW 300.31
Rotatable Bonds 5
TPSA 75.99
LogP 3.01
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 300.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Polygonum senegalense Polygonaceae Plantae 471708

Showing of synonyms

  • Midiwo JO, Matasi JJ, et al. (1992). Anti-feedant effects of surface accumulated flavonoids of Polygonum senegalense.. Bulletin of the Chemical Society of Ethiopia,1992,6(2),119-122. [View] [PubMed]
Pubchem: 7152435
Nmrshiftdb2: 70070895

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 300.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 300.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.26
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.580
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.05

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.080
Plasma Protein Binding
62.27
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.040
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.440
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.190
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
6.950
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.820
Rat (Acute)
2.320
Rat (Chronic Oral)
3.090
Fathead Minnow
4.830
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
382.920
Hydration Free Energy
-9.180
Log(D) at pH=7.4
2.740
Log(P)
2.83
Log S
-5.64
Log(Vapor Pressure)
-6.59
Melting Point
142.24
pKa Acid
7.25
pKa Basic
2.84
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9518
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9518
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.9434
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.9434
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9422
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9422
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9397
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9397
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9379
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9379
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9373
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9373
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9371
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9371
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9359
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9359
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9260
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9260
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9224
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9224
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9210
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9210
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9176
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9176
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9163
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9163
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9140
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9140
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9035
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9035
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9019
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9019
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9012
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9012
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8982
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8982
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8903
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8903
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8875
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8875
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8847
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8847
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.8815
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 3 0.8815
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8795
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 3 0.8795
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.8783
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.8783
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8762
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8762
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8760
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8760
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8758
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8758
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8757
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8757
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8753
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8753
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8728
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8728
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8683
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8683
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8621
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8621
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8611
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8611
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8599
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8599
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8579
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8579
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8571
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8571
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8571
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8571
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.8564
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.8564
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8560
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8560
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8521
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8521
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8494
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8494
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8481
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8481
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8448
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8448
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.8407
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.8407
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8350
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8350
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8310
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8310
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8299
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8299
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8298
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8298
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8290
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.8290
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8279
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8279
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8259
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8259
3-hydroxy-3-methylglutaryl-coenzyme A reductase P13702 MVAA_PSEMV Pseudomonas mevalonii 3 0.8253
3-hydroxy-3-methylglutaryl-coenzyme A reductase P13702 MVAA_PSEMV Pseudomonas mevalonii 3 0.8253
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8222
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8222
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 3 0.8214
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 3 0.8214
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.8202
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.8202
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8173
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.8173
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8173
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.8173
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8132
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8132
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.8115
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 3 0.8115
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8077
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8077
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8070
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8070
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8062
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8062
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8035
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8035
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8004
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8004
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8004
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8004
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7983
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7983
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7974
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7974
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7966
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7966
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7949
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7949
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7916
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7916
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7905
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7905
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7894
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7894
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7889
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7889
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7888
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7888
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7878
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7878
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7873
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7873
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7862
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7862
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7840
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7840
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7837
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7837
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7804
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7804
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7803
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7803
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7779
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7779
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7755
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7755
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7754
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7754
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7750
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7750
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7735
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7735
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7735
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7735
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7731
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7731
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7727
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7727
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7719
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7719
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.7704
Tyrosyl-DNA phosphodiesterase 2 Q9JJX7 TYDP2_MOUSE Mus musculus 3 0.7704
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7695
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7695
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7689
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7689
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7679
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7679
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7667
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7667
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7661
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7661
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7649
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7649
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7626
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7626
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7609
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7609
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7605
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7605
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7597
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7597
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7570
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7570
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7568
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7568
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7567
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7567
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7562
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7562
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7557
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7557
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7555
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7555
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7532
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7532
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7528
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7528
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7523
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7523
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7522
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7522
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7516
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7516
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7494
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 3 0.7494
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7492
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7492
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7488
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7488
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7477
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7477
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7477
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7477
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7469
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7469
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7466
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7466
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7465
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7465
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7464
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7464
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7445
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7445
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7438
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7438
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7423
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7423
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7422
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7422
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7421
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7421
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7409
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7409
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7408
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7408
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7399
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7399
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7398
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7398
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7398
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7398
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7390
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7390
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7382
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7382
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 4 0.7378
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 4 0.7378
Thiamine-monophosphate kinase O67883 THIL_AQUAE Aquifex aeolicus 3 0.7368
Thiamine-monophosphate kinase O67883 THIL_AQUAE Aquifex aeolicus 3 0.7368
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7355
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7355
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7353
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7353
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7342
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7342
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7324
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7324
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 3 0.7314
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 3 0.7314
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7312
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7312
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7299
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7299
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7299
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7299
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7296
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7296
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7296
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7296
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7285
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7285
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7284
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7284
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7281
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7281
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7278
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7278
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7274
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7274
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.7273
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 3 0.7273
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7271
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7271
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7271
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7271
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7267
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7267
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7264
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7264
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7263
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7263
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7263
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 2 0.7263
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7260
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7260
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7257
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7257
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7255
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7255
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7249
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7249
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7244
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7244
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7235
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7235
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 3 0.7234
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 3 0.7234
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7229
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7229
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7224
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7224
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7221
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7221
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7219
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7219
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7214
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7214
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7209
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7209
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7203
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7203
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7202
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7202
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7201
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7201
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7196
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7196
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7195
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7195
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7191
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7191
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7186
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7186
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7184
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 3 0.7184
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7181
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7181
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 3 0.7180
Ribonuclease 4 P15468 RNAS4_PIG Sus scrofa 3 0.7180
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7179
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7179
Amino acid ABC transporter D0VWX4 D0VWX4_GEOSE Geobacillus stearothermophilus 2 0.7177
Amino acid ABC transporter D0VWX4 D0VWX4_GEOSE Geobacillus stearothermophilus 2 0.7177
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7171
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7171
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.7169
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7169
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7169
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 3 0.7169
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7165
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7165
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7162
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7162
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7148
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7148
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7135
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7135
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7133
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7133
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7128
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7128
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7126
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7126
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7122
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7122
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7112
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7112
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7110
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7110
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7106
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7106
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7105
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7105
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7094
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 3 0.7094
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7089
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7089
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7089
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7089
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7079
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7079
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7079
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7079
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7077
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7077
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7076
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7076
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7071
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7071
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7067
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7067
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7066
Nucleoside diphosphate kinase Q9U1E1 Q9U1E1_LEIMA Leishmania major 3 0.7066
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7065
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7065
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7063
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7063
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7060
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7060
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7053
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7053
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7047
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7047
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7047
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7047
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7046
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7046
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7044
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7044
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7042
Cellular tumor antigen p53 P04637 P53_HUMAN Homo sapiens 3 0.7042
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 4 0.7037
Polymerase basic protein 2 Q2LG68 Q2LG68_9INFA Influenza A virus) 4 0.7037
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 3 0.7033
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 3 0.7033
ADP-ribosyl-[dinitrogen reductase] hydrolase A7XNI2 A7XNI2_AZOBR Azospirillum brasilense 2 0.7030
ADP-ribosyl-[dinitrogen reductase] hydrolase A7XNI2 A7XNI2_AZOBR Azospirillum brasilense 2 0.7030
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7028
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7028
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7024
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7024
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7016
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7016
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7015
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7015
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7014
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7014
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7013
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7013
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7011
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 3 0.7011
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7007
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7007
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7003
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7003

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