2'-dihydroxy-4',6'-dimethoxychalcone - Compound Card

2'-dihydroxy-4',6'-dimethoxychalcone

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2'-dihydroxy-4',6'-dimethoxychalcone

Structure
Zoomed Structure
  • Family: Polygonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(O)c(c(c1)OC)C(=O)/C(=C/c1ccccc1)/O
InChI InChI=1S/C17H16O5/c1-21-12-9-13(18)16(15(10-12)22-2)17(20)14(19)8-11-6-4-3-5-7-11/h3-10,18-19H,1-2H3/b14-8-
InChIKey HFZXUZJLQDOKEY-ZSOIEALJSA-N
Formula C17H16O5
HBA 5
HBD 2
MW 300.31
Rotatable Bonds 5
TPSA 75.99
LogP 3.19
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 300.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Polygonum senegalense Polygonaceae Plantae 471708

Showing of synonyms

  • Midiwo JO, Matasi JJ, et al. (1992). Anti-feedant effects of surface accumulated flavonoids of Polygonum senegalense.. Bulletin of the Chemical Society of Ethiopia,1992,6(2),119-122. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 208.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.31
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.430
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.19

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.140
Plasma Protein Binding
54.59
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.390
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.090
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.880
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.280
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.310
Rat (Acute)
2.150
Rat (Chronic Oral)
2.920
Fathead Minnow
4.530
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
383.250
Hydration Free Energy
-9.250
Log(D) at pH=7.4
2.430
Log(P)
2.6
Log S
-4.94
Log(Vapor Pressure)
-6.8
Melting Point
119.92
pKa Acid
7.61
pKa Basic
1.68
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9646
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9646
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9472
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9472
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9418
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9418
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9401
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.9401
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9362
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.9362
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9242
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9242
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9141
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9141
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9079
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9079
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9076
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9076
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9058
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9058
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9017
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9017
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9001
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.9001
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8990
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8990
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8955
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8955
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8874
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8874
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8796
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8796
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8751
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8751
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8731
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8731
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8716
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8716
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8713
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8713
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8699
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8699
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8699
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8699
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8677
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8677
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8649
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8649
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8643
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8643
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8629
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8629
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8626
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8626
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.8621
Lethal factor P15917 LEF_BACAN Bacillus anthracis 3 0.8621
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8609
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8609
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8605
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8605
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8589
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8589
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8553
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8553
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8539
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8539
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8529
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8529
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8515
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8515
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8496
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8496
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8440
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8440
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8422
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8422
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8349
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8349
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8339
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8339
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8331
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8331
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8297
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8297
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8293
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.8293
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8289
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8289
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8287
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8287
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8286
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.8286
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8284
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8284
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8258
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8258
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8238
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8238
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8232
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 3 0.8232
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8224
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8224
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8214
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8214
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8197
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8197
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8195
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8195
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8194
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8194
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8169
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 3 0.8169
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8149
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8149
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8139
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8139
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8094
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8094
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8090
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8090
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8085
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8085
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8052
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.8052
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8039
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8039
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8034
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.8034
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8027
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8027
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8026
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8026
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8001
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8001
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7998
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7998
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 3 0.7998
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7998
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7984
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7984
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7973
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7973
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7967
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7967
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7949
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7949
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7927
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7927
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.7920
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.7920
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7906
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7906
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7896
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7896
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7888
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7888
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7876
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7876
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7848
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7848
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7833
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7833
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7804
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7804
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7798
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7798
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7797
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7797
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7777
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7777
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7773
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7773
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7772
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7772
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7768
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7768
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7750
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7750
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7727
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7727
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7721
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7721
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7719
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7719
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7717
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.7717
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7682
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.7682
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7674
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7674
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7671
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7671
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7657
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7657
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7654
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7654
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7635
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7635
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7620
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7620
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7588
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7588
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7583
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7583
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7580
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7580
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7560
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7560
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7550
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.7550
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7521
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7521
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7515
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7515
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7511
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7511
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7508
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7508
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7500
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7500
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7499
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7499
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7493
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7493
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7489
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7489
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7476
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7476
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7471
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7471
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7464
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7464
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7457
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7457
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7454
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7454
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7454
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7454
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7440
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7440
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7434
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7434
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7431
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7431
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7423
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7423
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7422
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7422
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7422
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7422
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7410
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7410
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7407
Endoplasmic reticulum aminopeptidase 2 Q6P179 ERAP2_HUMAN Homo sapiens 2 0.7407
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7404
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7404
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7400
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7400
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7393
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7393
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 4 0.7381
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 4 0.7381
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7374
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7374
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.7373
clade A/E 93TH057 HIV-1 gp120 core A0A0M3KKW9 A0A0M3KKW9_9HIV1 Human immunodeficiency virus 1 3 0.7373
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7373
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7373
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7372
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7372
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7372
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7372
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7370
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7370
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7369
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7369
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7367
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7367
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7334
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7334
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7334
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7334
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7333
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7333
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7330
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7330
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7326
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7326
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7319
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7319
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7319
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7319
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7314
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7314
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7311
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7311
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7311
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7311
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7308
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7308
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7307
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7307
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7304
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7304
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7303
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7303
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7302
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7302
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7301
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7301
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7298
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7298
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7291
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7291
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7271
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7271
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7271
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7271
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7270
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7270
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7266
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7266
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7263
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7263
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7262
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7262
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7260
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7260
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7259
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7259
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7254
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7254
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7250
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7250
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7241
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7241
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7241
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7241
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7238
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7238
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7236
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7236
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7236
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7236
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7231
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7231
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7225
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7225
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7224
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7224
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7218
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7218
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7213
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7213
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7211
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7211
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7207
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7207
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7205
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7205
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7205
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7205
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7203
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7203
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7200
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7200
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7197
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7197
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7190
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.7190
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7189
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7189
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7186
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7186
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7181
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7181
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7180
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7180
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7177
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7177
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7174
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7174
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7172
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7172
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7165
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7165
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7133
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7133
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7132
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7132
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7131
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7131
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7126
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7126
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7126
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 3 0.7126
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7125
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7125
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7123
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7123
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7112
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7112
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7112
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7112
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7112
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7112
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7108
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7108
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7103
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7103
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7079
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7079
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7070
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7070
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7068
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7068
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7067
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7067
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7064
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7064
L-glutamine synthetase Q1QZR8 Q1QZR8_CHRSD Chromohalobacter salexigens 3 0.7061
L-glutamine synthetase Q1QZR8 Q1QZR8_CHRSD Chromohalobacter salexigens 3 0.7061
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7051
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7051
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7048
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7048
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7041
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7041
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7038
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7038
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7035
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7035
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7034
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7034
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7033
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7033
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7032
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7032
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7025
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7025
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7015
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7015
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7013
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7013
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7006
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7006
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7005
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 O50008 METE1_ARATH Arabidopsis thaliana 2 0.7005
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7004
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7004

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