5-hydroxy-7-methoxyflavanone - Compound Card

5-hydroxy-7-methoxyflavanone

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5-hydroxy-7-methoxyflavanone

Structure
Zoomed Structure
  • Family: Plantae - Polygonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc2OC(CC(=O)c2c(c1)O)c1ccccc1
InChI InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3
InChIKey ORJDDOBAOGKRJV-UHFFFAOYSA-N
Formula C16H14O4
HBA 4
HBD 1
MW 270.28
Rotatable Bonds 2
TPSA 55.76
LogP 3.11
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 270.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Polygonum senegalense Polygonaceae Plantae 471708

Showing of synonyms

  • Midiwo JO, Matasi JJ, et al. (1992). Anti-feedant effects of surface accumulated flavonoids of Polygonum senegalense.. Bulletin of the Chemical Society of Ethiopia,1992,6(2),119-122. [View] [PubMed]
Pubchem: 4101463
Nmrshiftdb2: 60024489
CPRiL: 57985
Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 270.28 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 270.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 270.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.64
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.500
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.07

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.210
Plasma Protein Binding
54.97
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.910
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.420
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.590
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.810
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.300
Rat (Acute)
1.830
Rat (Chronic Oral)
2.160
Fathead Minnow
4.540
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
375.420
Hydration Free Energy
-8.450
Log(D) at pH=7.4
3.230
Log(P)
3.33
Log S
-4.73
Log(Vapor Pressure)
-6.7
Melting Point
108.06
pKa Acid
7.9
pKa Basic
4.31
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9859
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9859
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9764
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9764
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9534
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9534
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9523
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9523
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9506
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9506
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9370
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9370
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9363
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9363
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9354
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9354
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9317
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9317
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9301
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9301
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9300
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9300
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9300
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9300
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9250
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9250
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9195
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9195
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9180
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9180
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9166
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9166
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9144
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9144
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.9083
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.9083
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9075
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9075
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9054
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9054
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9044
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9044
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9041
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9041
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9032
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9032
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9013
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9013
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8998
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8998
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8923
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8923
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8835
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8835
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8795
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8795
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8778
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8778
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8777
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8777
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8769
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8769
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8715
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8715
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8715
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8715
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8599
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8599
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8589
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8589
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8576
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8576
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8543
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8543
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8541
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8541
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8529
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8529
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8504
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8504
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8494
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8494
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8491
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8491
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8471
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8471
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8453
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8453
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8443
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8443
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8440
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8440
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8405
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8405
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8395
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8395
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8380
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8380
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8358
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8358
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8354
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8354
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8307
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8307
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8301
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8301
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8293
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8293
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8248
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8248
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8206
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8206
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8186
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8186
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8176
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8176
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8173
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8173
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8172
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8172
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8167
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8159
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8159
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8152
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8152
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8137
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8137
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8112
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8112
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8106
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.8106
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.8106
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8106
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8085
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8085
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8075
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8075
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8067
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8067
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8044
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8044
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8041
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8041
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8029
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8029
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.8024
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.8024
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8014
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8014
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8006
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8006
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7991
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7991
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7986
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7986
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7981
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7981
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7953
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7953
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7953
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7953
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7920
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7920
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7901
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7901
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7896
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7896
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7895
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7895
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7878
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7878
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7876
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7876
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7873
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7873
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7870
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7870
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7851
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7851
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7849
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7849
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7847
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7847
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7831
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.7831
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7827
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7827
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7827
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7827
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7812
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7812
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7796
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7796
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7785
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7785
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7775
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7775
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7770
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7770
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7757
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7757
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7755
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7755
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7732
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7732
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7719
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7719
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7709
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7709
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7709
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7709
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7684
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7684
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7682
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7682
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7676
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7676
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7670
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7670
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7657
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7657
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7652
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7652
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7648
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7648
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7634
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7634
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7627
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7627
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7604
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7604
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7596
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7596
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7594
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7594
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7589
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7589
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7571
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7571
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7566
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7566
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7547
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 3 0.7547
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7538
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7538
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7531
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7531
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7521
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7521
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7520
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7520
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7514
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7514
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7513
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.7513
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7493
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7493
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7488
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7488
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7483
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7483
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7483
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7483
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7473
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7473
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7473
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7473
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7469
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7469
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7463
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7463
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7454
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7454
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7446
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7446
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7444
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7444
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7444
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7444
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7441
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7441
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7440
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7440
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7434
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7434
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7433
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7433
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7430
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7430
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7428
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7428
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7422
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7422
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7421
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7421
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7407
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7407
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7403
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7396
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7396
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7396
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7396
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7394
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7394
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7387
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7387
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7374
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7374
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7374
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7374
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7374
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7374
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7370
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7370
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7363
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7363
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7358
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7358
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7354
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7354
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7352
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7352
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7350
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7350
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7347
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7347
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7342
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7342
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7330
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7330
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7329
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7329
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7327
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7327
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7327
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7327
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7317
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7317
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7316
Serine/threonine-protein kinase VRK1 Q99986 VRK1_HUMAN Homo sapiens 3 0.7316
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7312
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7312
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7300
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7300
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7300
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7300
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7288
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7288
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7287
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7287
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 4 0.7274
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 4 0.7274
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7273
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7273
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7271
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7271
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7270
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7270
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7269
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7269
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7252
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7252
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7249
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7249
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7247
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7247
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7242
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7242
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7236
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7236
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7219
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7219
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7218
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7218
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7217
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7215
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7215
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7214
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7214
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7208
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7208
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7200
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7200
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7200
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7200
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7195
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7195
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7190
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7190
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7189
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7189
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7181
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7181
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7178
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7178
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7177
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7177
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7172
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7172
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7160
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7160
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7156
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7156
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7147
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7147
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7140
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7140
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7140
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7140
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7139
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7139
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7138
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7138
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7137
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7137
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7134
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7134
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7133
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7133
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7132
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7132
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7129
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7129
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7127
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7127
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7126
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7126
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7125
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7125
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7121
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7121
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7117
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7117
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7117
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7117
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7116
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7116
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7106
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7106
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7106
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7106
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7102
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7102
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7101
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7101
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7096
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7096
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7095
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7095
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7093
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7093
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7092
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7092
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7091
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7091
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7087
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7087
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7085
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7085
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7085
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7085
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7075
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7075
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7072
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7072
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7071
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7071
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7070
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7070
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7068
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7068
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7067
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7067
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7066
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7066
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7060
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7060
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7060
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7060
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7056
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7056
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7050
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7050
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7044
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7044
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 3 0.7040
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 3 0.7040
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7036
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7036
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 3 0.7036
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7036
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7033
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7033
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7026
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7026
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7025
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7025
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7024
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7024
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7023
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7023
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7021
GTPase IMAP family member 2 Q9UG22 GIMA2_HUMAN Homo sapiens 3 0.7021
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7016
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7016
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7015
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7015
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7014
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7014

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