Pseudo-aspidinol iB - Compound Card

Pseudo-aspidinol iB

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Pseudo-aspidinol iB

Structure
Zoomed Structure
  • Family: Plantae - Rosaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles COc1c(c(O)cc(c1C)O)C(=O)C(C)C
InChI InChI=1S/C12H16O4/c1-6(2)11(15)10-9(14)5-8(13)7(3)12(10)16-4/h5-6,13-14H,1-4H3
InChIKey AMZOOBLDBPAFJZ-UHFFFAOYSA-N
Formula C12H16O4
HBA 4
HBD 2
MW 224.26
Rotatable Bonds 3
TPSA 66.76
LogP 2.25
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 16
Formal Charge 0
Fraction CSP3 0.42
Exact Mass 224.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hagenia abyssinica Rosaceae Plantae 57921

Showing of synonyms

  • Gemech M, Dagne E. (2007). Chemical study of anti-termite extract of saw dust of Hagenia abyssinica. M.Sc. Thesis-4, Addis Ababa University, Ethiopia, 2007. [View] [PubMed]
Pubchem: 71364191

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 224.26 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.47
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.540
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.01

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.560
Plasma Protein Binding
34.45
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.950
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.540
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.280
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.100
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.700
Rat (Acute)
2.030
Rat (Chronic Oral)
2.640
Fathead Minnow
4.010
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
318.750
Hydration Free Energy
-9.860
Log(D) at pH=7.4
2.060
Log(P)
2.91
Log S
-3.41
Log(Vapor Pressure)
-4.44
Melting Point
97.43
pKa Acid
8.07
pKa Basic
6.55
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9439
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9439
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9315
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9315
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9314
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9314
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9193
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9193
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.9168
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.9168
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.9125
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.9125
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9065
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9065
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 3 0.9049
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 3 0.9049
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9047
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9047
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9020
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9020
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8995
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.8995
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8979
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8979
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8977
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8977
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8960
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8960
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8910
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8910
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8847
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8847
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.8820
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.8820
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8806
Aromatase P11511 CP19A_HUMAN Homo sapiens 3 0.8806
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8801
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8801
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8745
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8745
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8729
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8729
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8728
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8728
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8715
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8715
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8692
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8692
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8656
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.8656
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8634
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8634
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8622
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8622
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8618
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8618
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8598
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.8598
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8556
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8556
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8507
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8507
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8489
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8489
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8487
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.8487
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.8441
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.8441
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8435
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8435
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8424
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8424
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8407
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8407
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8378
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8378
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8369
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8369
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8295
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8295
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8265
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8265
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8251
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8251
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8232
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.8232
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 3 0.8184
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 3 0.8184
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8159
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8159
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8151
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8151
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8118
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8118
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8101
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8101
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8096
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8096
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8081
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8081
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8071
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8071
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8065
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8065
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8045
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8045
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8025
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8025
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8024
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8024
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8015
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8015
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7999
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7999
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7974
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7974
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7940
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7940
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7915
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7915
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7869
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7869
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7859
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7859
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7847
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7847
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7840
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7840
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7831
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7831
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7830
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7830
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7821
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7821
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7819
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.7819
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.7794
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.7794
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7774
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7774
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7771
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7771
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7771
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7771
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7761
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7761
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7748
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7748
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7739
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7739
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7721
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7721
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7715
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7715
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7705
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 4 0.7705
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7672
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7672
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7670
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7670
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7662
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7662
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 4 0.7661
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 4 0.7661
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7657
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7657
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7646
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7646
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7597
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7597
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7588
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7588
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7585
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7585
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7584
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7584
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7577
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7577
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7571
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7571
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7568
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 3 0.7568
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7556
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7556
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7549
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7549
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7536
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7536
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7531
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 4 0.7531
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7503
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7503
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7501
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7501
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7493
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7493
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7474
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7474
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7461
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7461
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7460
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7460
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7448
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7448
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7430
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7430
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7424
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7424
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7422
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7422
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7416
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7416
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7378
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7378
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7378
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7378
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7348
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7348
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7339
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7339
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7339
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7339
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7337
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7337
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7333
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7333
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7327
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7327
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7325
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7325
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7324
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7324
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7322
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7322
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7313
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7313
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7305
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7305
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7300
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7300
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7287
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7287
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7281
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7281
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7281
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7281
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7279
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7279
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7272
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7272
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7266
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7266
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7262
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7262
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7260
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7260
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.7259
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.7259
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7253
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7253
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7243
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7243
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7231
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7231
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7230
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7230
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7223
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7223
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7211
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7211
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7211
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7211
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7210
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7210
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7210
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7210
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7200
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 3 0.7200
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7196
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7196
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7194
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7194
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7194
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7194
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7191
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7191
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7172
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7172
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7171
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7171
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7166
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7166
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7165
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.7165
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7164
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7164
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7161
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7161
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7156
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7156
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7155
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7155
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7152
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7152
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7151
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7151
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7146
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7146
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7143
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7143
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7142
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7142
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7141
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7141
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7136
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7136
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7125
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7125
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7121
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7121
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7120
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 3 0.7120
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7119
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7119
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7113
Androgen receptor P19091 ANDR_MOUSE Mus musculus 3 0.7113
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7108
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7108
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7104
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7104
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7093
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7093
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 4 0.7088
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 4 0.7088
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7080
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7080
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7078
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7078
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7074
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7074
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7073
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7073
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7072
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7072
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 5 0.7071
Deoxynucleoside kinase Q9XZT6 DNK_DROME Drosophila melanogaster 5 0.7071
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7070
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 3 0.7070
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7059
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7059
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7057
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7057
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7054
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7054
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7052
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7052
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7051
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7051
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7050
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7050
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7048
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7048
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7046
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7046
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7034
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7034
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7033
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7033
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7031
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7031
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7030
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7030
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7028
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.7028
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7028
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7028
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7023
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7023
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7014
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7014
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7008
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7008
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7007
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7007

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