2-methoxy-3-methylanthraquinone - Compound Card

2-methoxy-3-methylanthraquinone

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2-methoxy-3-methylanthraquinone

Structure
Zoomed Structure
  • Family: Plantae - Rubiaceae
  • Kingdom: Plantae
  • Class: Quinone
Canonical Smiles COc1cc2c(cc1C)C(=O)c1c(C2=O)cccc1
InChI InChI=1S/C16H12O3/c1-9-7-12-13(8-14(9)19-2)16(18)11-6-4-3-5-10(11)15(12)17/h3-8H,1-2H3
InChIKey YJILUWQPXMLLTN-UHFFFAOYSA-N
Formula C16H12O3
HBA 3
HBD 0
MW 252.27
Rotatable Bonds 1
TPSA 43.37
LogP 2.78
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 252.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pentas longiflora Rubiaceae Plantae 387060

Showing of synonyms

  • El-Hady S, Bukuru J, et al. (2002). New pyranonaphthoquinone and pyranonaphthohydroquinone from the roots of Pentas longiflora. Journal of Natural Products,2002,65(9),1377-1379. [View] [PubMed]
Pubchem: 10514946
Nmrshiftdb2: 70041912

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)C(=O)c3c(C2=O)cccc3

Level: 0

Mol. Weight: 252.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.63
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.300
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.41

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.990
Plasma Protein Binding
61.62
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.610
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.860
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.880
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.980
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.560
Rat (Acute)
2.130
Rat (Chronic Oral)
2.030
Fathead Minnow
4.710
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
393.310
Hydration Free Energy
-7.180
Log(D) at pH=7.4
2.540
Log(P)
4.07
Log S
-5.56
Log(Vapor Pressure)
-6.17
Melting Point
188.68
pKa Acid
8.64
pKa Basic
3.48
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9755
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9755
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9403
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9403
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9399
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9399
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9391
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9391
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9345
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9345
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9335
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9335
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9103
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9103
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8901
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8901
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8887
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8887
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8847
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.8847
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8843
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8843
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8743
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8743
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8734
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8734
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8716
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8716
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8555
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8555
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8523
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8523
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8424
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8424
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8396
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.8396
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8305
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8305
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8281
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.8281
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.8246
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.8246
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.8220
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.8220
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8157
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8157
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8143
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8143
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8139
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8139
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.8134
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.8134
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8060
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8060
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8031
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8031
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.8018
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.8018
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.8014
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.8014
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.8002
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.8002
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7997
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7997
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7980
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7980
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7966
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7966
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7923
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7923
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7913
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7913
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7838
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7838
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7831
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7831
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7824
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7824
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7762
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7762
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7738
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7738
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7733
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7733
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7723
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7723
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7700
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7700
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7679
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7679
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7672
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7672
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7671
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7671
2-Hydroxyacid oxidase 1 Q9UJM8 HAOX1_HUMAN Homo sapiens 3 0.7662
2-Hydroxyacid oxidase 1 Q9UJM8 HAOX1_HUMAN Homo sapiens 3 0.7662
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7655
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7655
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7645
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7645
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7644
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 4 0.7644
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7634
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7634
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7632
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7632
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7621
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7621
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7593
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7593
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7547
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7547
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7533
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7533
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7528
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7528
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7520
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7520
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7503
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7503
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7477
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.7477
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7468
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7468
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7467
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7467
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7461
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7461
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7450
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7450
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7450
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7450
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7443
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7443
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7442
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.7442
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7438
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7438
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7429
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7429
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7420
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7420
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7409
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7409
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.7390
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.7390
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7388
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7388
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7383
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7383
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7379
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7379
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7378
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7378
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7376
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7376
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7337
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7337
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7318
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7318
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7316
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7316
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7314
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7314
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7310
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7310
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 2 0.7309
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 2 0.7309
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7285
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7285
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7271
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7271
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7269
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7269
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 3 0.7268
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic P80030 FABI_BRANA Brassica napus 3 0.7268
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7248
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7248
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7207
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7207
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7201
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7201
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7198
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7198
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7185
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7185
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7185
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7185
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7174
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7174
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7170
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7170
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7150
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7150
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7124
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7124
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7118
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7118
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7113
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.7113
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7111
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7111
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7106
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 3 0.7106
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7104
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7104
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7098
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7098
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7092
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7092
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7081
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7081
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7075
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7075
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7070
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7070
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7061
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7061
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7051
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7051
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7047
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7047
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7031
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7031
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7031
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7031
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7013
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7013
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7013
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7013
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7004
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7004

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