Normelicopicine - Compound Card

Normelicopicine

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Normelicopicine

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles COc1c(OC)c(OC)c2c(c1O)c(=O)c1c(n2C)cccc1
InChI InChI=1S/C17H17NO5/c1-18-10-8-6-5-7-9(10)13(19)11-12(18)15(21-2)17(23-4)16(22-3)14(11)20/h5-8,20H,1-4H3
InChIKey UGEKWKMLXLFVIY-UHFFFAOYSA-N
Formula C17H17NO5
HBA 6
HBD 1
MW 315.32
Rotatable Bonds 3
TPSA 69.92
LogP 2.42
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 315.11
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Teclea trichocarpa Rutaceae Plantae 2695420

Showing of synonyms

  • Muriithi MW, Abraham WR, et al. (2002). Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine. Journal of Natural Products,2002,65(7),956-959. [View] [PubMed]
Pubchem: 5378563
Nmrshiftdb2: 70014534

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)[nH]c3c(c2=O)cccc3

Level: 0

Mol. Weight: 315.32 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.47
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.460
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.8

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.560
Plasma Protein Binding
63.92
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.690
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.650
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.720
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.510
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.120
Rat (Acute)
2.350
Rat (Chronic Oral)
2.600
Fathead Minnow
5.090
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
410.580
Hydration Free Energy
-8.970
Log(D) at pH=7.4
1.650
Log(P)
2.35
Log S
-4.44
Log(Vapor Pressure)
-6.99
Melting Point
198.79
pKa Acid
5.95
pKa Basic
3.05
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9579
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9579
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9306
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9306
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9295
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9295
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.9285
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 4 0.9285
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.9191
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 4 0.9191
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.9178
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.9178
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9156
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9156
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9142
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9142
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9097
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9097
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9095
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9095
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9066
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9066
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9050
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9050
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.9038
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.9038
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8981
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8981
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8972
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8972
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8959
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.8959
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8920
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8920
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8917
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8917
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8915
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8915
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8910
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8910
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8906
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8906
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8744
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8744
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8735
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8735
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8709
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8709
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8706
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8706
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8696
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8696
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8651
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8651
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8641
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8641
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8577
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8577
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8559
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8559
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8553
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8553
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8539
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8539
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8521
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8521
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8501
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8501
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8500
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8500
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8492
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8492
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8450
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8450
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8446
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8446
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8427
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8427
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8413
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8413
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8408
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8408
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8335
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8335
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8312
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8312
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8303
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8303
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8207
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8207
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8170
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8170
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8150
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8150
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8143
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8143
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8133
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8133
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8124
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8124
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8102
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8102
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8091
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8091
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.8089
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.8089
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8084
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8084
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8064
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8064
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8055
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8055
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8039
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8039
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8022
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8022
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8014
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8014
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7991
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7991
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7987
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7987
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7939
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7939
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7914
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7914
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7914
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7914
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7897
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7897
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7864
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7864
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7864
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7864
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7847
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.7847
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7804
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7804
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7796
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7796
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7740
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7740
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7729
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7729
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7727
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.7727
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7713
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7713
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7711
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7711
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7680
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7680
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7662
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7662
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7660
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7660
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7657
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7657
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7630
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7630
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7626
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7626
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7617
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7617
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7602
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7602
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7597
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7597
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7596
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7596
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7588
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7588
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7585
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7585
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7565
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7565
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7557
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7557
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7554
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.7554
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7542
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7542
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7533
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7533
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7530
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7530
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7527
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7527
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7527
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 4 0.7527
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7525
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7525
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7518
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7518
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7510
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7510
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7505
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7505
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7492
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7492
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7478
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7478
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7445
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7445
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7439
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7439
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7434
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7434
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7432
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7432
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7410
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7410
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7405
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7405
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7402
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7402
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7398
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7398
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7394
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7394
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7393
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7393
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7389
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7389
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7382
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7382
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7381
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7381
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7366
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7366
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7366
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7366
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7354
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 4 0.7354
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7351
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7351
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7349
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.7349
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7338
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7338
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7322
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7322
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7318
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7318
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7306
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7306
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7298
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7298
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7296
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7296
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7280
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7280
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7273
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7273
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7254
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 4 0.7254
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7250
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7250
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7247
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7247
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7233
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7233
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7231
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7231
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7229
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7229
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7215
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7215
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7211
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7211
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7210
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7210
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7210
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7210
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7189
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7189
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7177
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7177
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7172
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7172
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7171
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7171
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7169
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7169
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7167
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7150
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7150
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7149
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7149
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7147
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7147
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7126
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7126
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7126
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7126
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7115
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7115
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7113
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7113
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7109
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7109
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7107
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7107
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7100
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7100
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7096
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7096
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7096
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7096
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7092
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 4 0.7092
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7091
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7091
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7088
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7088
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.7084
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.7084
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7083
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7083
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7072
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7072
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7070
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7070
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7067
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7067
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7058
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7058
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7054
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7054
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7041
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7041
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7014
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7014
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7014
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7014
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7011
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7011

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