Melicopicine - Compound Card

Melicopicine

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Melicopicine

Structure
Zoomed Structure
  • Family: Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles COc1c(OC)c(OC)c2c(c1OC)n(C)c1c(c2=O)cccc1
InChI InChI=1S/C18H19NO5/c1-19-11-9-7-6-8-10(11)14(20)12-13(19)16(22-3)18(24-5)17(23-4)15(12)21-2/h6-9H,1-5H3
InChIKey URPVDDXMEZAEJY-UHFFFAOYSA-N
Formula C18H19NO5
HBA 6
HBD 0
MW 329.35
Rotatable Bonds 4
TPSA 58.92
LogP 2.73
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.28
Exact Mass 329.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Teclea trichocarpa Rutaceae Plantae 2695420

Showing of synonyms

  • Muriithi MW, Abraham WR, et al. (2002). Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine. Journal of Natural Products,2002,65(7),956-959. [View] [PubMed]
Pubchem: 101253
Kegg Ligand: C10722
Chebi: 6734
Nmrshiftdb2: 60072570

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)[nH]c3c(c2=O)cccc3

Level: 0

Mol. Weight: 195.22 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.49
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.240
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.27

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.430
Plasma Protein Binding
60.57
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.310
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.950
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.500
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.000
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.540
Rat (Acute)
2.520
Rat (Chronic Oral)
2.260
Fathead Minnow
5.390
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
426.190
Hydration Free Energy
-8.680
Log(D) at pH=7.4
1.740
Log(P)
2.02
Log S
-3.87
Log(Vapor Pressure)
-6.55
Melting Point
181.9
pKa Acid
7.92
pKa Basic
1.66
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9600
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9600
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9501
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9501
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9471
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9471
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9359
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9359
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9233
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9233
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9232
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9232
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9204
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9204
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9128
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9128
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8993
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8993
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8856
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8856
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8755
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8755
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8697
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8697
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8688
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8688
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8657
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8657
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8656
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8656
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8624
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8624
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8581
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8581
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8552
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8552
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8551
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8551
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8507
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8507
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8479
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8479
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8436
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8436
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8405
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8405
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8390
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8390
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8376
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8376
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8361
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8361
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8318
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8318
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8306
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8306
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8167
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8167
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8088
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8088
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8054
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8054
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8026
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.8026
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8005
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8005
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7989
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7989
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7932
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7932
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7926
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7926
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7840
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7840
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7838
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7838
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7816
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7816
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7791
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7791
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7769
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7769
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7763
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7763
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7760
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7760
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7754
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7754
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7741
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7741
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7699
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7670
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7670
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7667
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7667
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7662
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7662
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7623
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 3 0.7623
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7609
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7609
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7608
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7608
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7605
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7605
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7602
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7602
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7598
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7598
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7588
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7588
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7537
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7537
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7536
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7536
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7535
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7535
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7527
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7527
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7523
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7523
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7520
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7520
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7500
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7500
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7495
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7495
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7472
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7472
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7450
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7450
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7443
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7443
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7434
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7434
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7434
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7434
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7427
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7427
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7424
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7424
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7412
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7412
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7411
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7411
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7411
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7411
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7406
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7406
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7394
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7394
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7382
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7382
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7374
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7374
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7371
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7371
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7371
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7371
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7366
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7366
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7357
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7357
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7341
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7341
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7340
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7340
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7334
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7334
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7321
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7321
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7321
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7321
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7317
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7317
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7317
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7317
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7316
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7316
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7308
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7308
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7306
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7306
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7303
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7303
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7288
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7288
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7275
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7275
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7273
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7273
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7271
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7271
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7268
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7268
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7234
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7234
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7220
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7220
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7218
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7218
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7214
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7214
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7212
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7212
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7197
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7197
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7194
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7194
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7187
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7187
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7181
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7181
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7180
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7180
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7171
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7171
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7168
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7168
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7161
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7161
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7150
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7150
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7145
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7145
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7137
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7137
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7135
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7135
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7134
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7134
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7121
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7121
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7121
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7121
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7120
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7120
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7108
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7108
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7084
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7084
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7083
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7083
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7064
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7064
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7048
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7048
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7047
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7047
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7029
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7029
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7024
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7024
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7015
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7015
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7014
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7014

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